Navigation Links
Tiny genetic differences have huge consequences: McGill researchers
Date:1/18/2008

This release is available in French.

A study led by McGill University researchers has demonstrated that small differences between individuals at the DNA level can lead to dramatic differences in the way genes produce proteins. These, in turn, are responsible for the vast array of differences in physical characteristics between individuals. The study, part of the Genome Regulators in Disease (GRID) Project funded by Genome Canada and Genome Quebec, was led by Dr. Jacek Majewski of McGill Universitys Department of Human Genetics and the McGill University and Genome Quebec Innovation Centre, and first-authored by his research associate Dr. Tony Kwan. It was published January 13 in the journal Nature Genetics.

The study was originally initiated by Dr. Tom Hudson, former director of the McGill University and Genome Quebec Innovation Centre, and drew upon the data collected by the vast HapMap (Haplotype Map) Project, a global comparative map of the human genome, which Hudson and his colleagues were instrumental in completing.

This study solves in part the mystery of how a relatively small number of differences within DNA protein coding sequences could be responsible for the enormous variety of phenotypic differences between individuals. It had previously been shown that individual differences reside in simple, relatively small variations in the DNA sequence called single nucleotide polymorphisms (SNPs, often pronounced snips), which exist primarily in the junk code of the DNA not previously known to have any profound genetic effect.

There are many SNPs, explained Dr. Majewski. If you add them all together, you'd expect that two individuals would differ at more than a million of those positions. So we have a million or more small differences that distinguish you and me, and yet it would be very hard to explain all the phenotypic differences in the way
'/>"/>

Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic Alliance names Genetic Testing as its official journal
2. Should children be permitted to get genetic testing for BRCA 1/2 mutations?
3. Genetically modified carrots provide more calcium
4. UBC discovery unlocks tree genetics, gives new hope for pine beetle defense
5. New method developed to identify genetic determinants of Alzheimers disease
6. Study suggests genetic connection between short stature and arthritis
7. New genetic variants associated with lipid levels, risk for coronary artery disease
8. Scientists associate 6 new genetic variants with heart disease risk factor
9. Dissecting the genetic components of adaptation of E. coli to the mouse gut
10. Researchers move 2 steps closer to understanding genetic underpinnings of autism
11. Genetic breakthrough offers promise in tackling kidney tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... if you,re over 24 years of age you,ve already ... performance, according to a new Simon Fraser University study. ... associate professor Mark Blair, Thompson,s thesis supervisor, and Andrew ... the news in a just-published PLOS ONE ... social science experiments to rest on big data, the ...
(Date:4/14/2014)... in the Puerto Rican climate over the past three ... coqui frog, the territory,s national animal. UCLA biologists have ... but their mating call has also become shorter and ... UCLA distinguished professor of integrative biology and physiology and ... UCLA physics researcher, the study examined 170 male coqui ...
(Date:4/14/2014)... face the decision of whether to get a ... decision can be even more challenging. Now, a ... decisions in families of children with autism and ... parents reported the benefits of dog ownership included ... to learn responsibility. , "Children with autism spectrum ...
Breaking Biology News(10 mins):Study says we're over the hill at 24 2Climate change a likely culprit in coqui frog's altered calls, say UCLA biologists 2Dog ownership benefits families of children with autism, MU researcher finds 2
... approved for use by the U.S. Food and Drug ... the growth and invasiveness of ovarian cancer cells and ... UCLA,s Jonsson Comprehensive Cancer Center found. The drug, ... effective in fighting ovarian cancer in cell lines in ...
... NEW YORK and LAS VEGAS, Nov. 9 CBS ... an Omnicom Media Group company, today announced a new research partnership ... research facility housed in the MGM Grand Hotel in Las Vegas. ... Vision with one of the county,s leading agencies, will be called ...
... wet ethanol production method that begins by soaking corn ... of ethanol and more usable co-products, giving ethanol producers ... 20 percent. "The conventional ethanol production method has ... soluble, it doesn,t have any other co-products," said University ...
Cached Biology News:FDA approved leukemia drugs shows promise in ovarian cancer cells 2CBS and OMD Partner to Provide the Agency With Access to the Network's Television City Research Facility in Las Vegas 2CBS and OMD Partner to Provide the Agency With Access to the Network's Television City Research Facility in Las Vegas 3CBS and OMD Partner to Provide the Agency With Access to the Network's Television City Research Facility in Las Vegas 4Wet ethanol production process yields more ethanol and more co-products 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... ARIUS Research Inc., (TSX:,ARI), a biotechnology company ... therapeutics, today announced its financial and operational,results ... ended May 31st, 2008., "Throughout the ... moving,ARIUS, anti-cancer antibodies towards human clinical trial. ...
... , The white blood cells in our body combat ... leukemia, the formation of white blood cells is disturbed: ... multiply out of control without fully maturing. This process ... more susceptible to infections. T-ALL, a particular form of ...
... electronic device is an important step toward helping astronomers ... universe. This invisible light makes up 98% of the ... insights into the earliest stages of star and galaxy ... new circuit, developed by physicsts at Rutgers University, NASA,s ...
Cached Biology Technology:ARIUS announces second quarter fiscal 2008 financial results 2ARIUS announces second quarter fiscal 2008 financial results 3ARIUS announces second quarter fiscal 2008 financial results 4ARIUS announces second quarter fiscal 2008 financial results 5ARIUS announces second quarter fiscal 2008 financial results 6ARIUS announces second quarter fiscal 2008 financial results 7ARIUS announces second quarter fiscal 2008 financial results 8ARIUS announces second quarter fiscal 2008 financial results 9ARIUS announces second quarter fiscal 2008 financial results 10ARIUS announces second quarter fiscal 2008 financial results 11ARIUS announces second quarter fiscal 2008 financial results 12ARIUS announces second quarter fiscal 2008 financial results 13ARIUS announces second quarter fiscal 2008 financial results 14ARIUS announces second quarter fiscal 2008 financial results 15Not the protein, but its location in the cell, determines the onset of leukemia 2Nano-sized electronic circuit promises bright view of early universe 2Nano-sized electronic circuit promises bright view of early universe 3
... (eIF4E-binding protein II) is involved in translation ... kidney. PHAS proteins bind to eIF-4E, the ... capped mRNA in vitro and in cells. ... of PHAS/eIF-4E complexes. This allows eIF-4E to ...
... 2 (VMAT2). An antibody made to the ... at ~55 kDa in postnuclear supernatants of ... wild type cells (2). Some additional bands, ... also detected and remain unaffected by the ...
... Anti-Matrix Metalloproteinase-2, Hinge Region By immunoblotting ... native protein. It reacts with free MMP-2 ... antibody buffered aqueous glycerol solution ... pH 7.4, containing 50% glycerol and 15 ...
Acetylcholinesterase from human and monkey....
Biology Products: