Navigation Links
Tiny differences in our genes help shed light on the big picture of human history
Date:4/29/2009

By examining very small differences in people's genes, scientists from Cornell University have developed a new tool for identifying big events in human history and pinpointing the origins of specific gene mutations. This research, published in the May issue of the journal GENETICS (http://www.genetics.org), helps shed light on times when the human population moved close to extinction and helps scientists close in on gene mutations that make some demographic groups more likely to develop diseases such as cancer, heart disease, diabetes, among others.

"We know that many diseases are caused by a combination of genetic and environmental factors," said Kirk E. Lohmueller, one of the researchers involved in the work from Cornell University. "To find the genes that contribute to disease, it's very helpful to know the demographic history of the population being studied. Accurate estimates of population events help inform the search for mutations that might have been helpful and necessary for survival at the time, but no longer necessary and potentially harmful today."

In their work, Lohmueller and colleagues confirmed the existence of a major decline in European populations (called a "bottleneck") 32,500-47,500 years ago. They used computer simulations to model the expected correlation among segments of DNA containing very small genetic mutations that only involve a single letter of the genetic code (called "single nucleotide polymorphisms" or SNPs). Prior to this development, methods used to identify major population events relied on the frequency patterns of individual SNPs, while ignoring the patterns of specific groups of SNPs. This work shows that looking at groups of SNPs helps us better understand what happened long before there was a human historical record.

"When we think of the past, we often think in terms of the historical or geological records," said Mark Johnston, Editor-in-Chief of the journal GENETICS. "What makes this development so amazing is that it helps align these records with an emerging biological record based on our DNA. This technique can be applied to any species, making it possible for us to learn and compare the biological histories of all living creatures."


'/>"/>

Contact: Tracey DePellegrin Connelly
td2p@andrew.cmu.edu
412-268-1812
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. St. Jude influenza survey uncovers key differences between bird flu and human flu
2. Claims of sex-related differences in genetic association studies often not properly validated
3. Genetic differences in clover make one type toxic
4. Analysis of breast and colon cancer genes finds many areas of differences between tumors
5. Worms take the sniff test to reveal sex differences in brain
6. Tiny genetic differences have huge consequences: McGill researchers
7. Sex differences in the brains serotonin system
8. Negligent, attentive mouse mothers show biological differences
9. Defining DNA differences to track and tackle typhoid
10. Researchers note differences between people and animals on calorie restriction
11. Study sheds light on genetic differences that cause a childhood eye disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... , February 3, 2016 ... new market research report "Automated Fingerprint Identification System Market ... Latent Search), Application (Banking & Finance, Government, Healthcare, and ... by MarketsandMarkets, the market is expected to be worth ... of 21.0% between 2015 and 2020. The transformation and ...
(Date:2/3/2016)... , Feb. 3, 2016 ... the addition of the "Emotion Detection ... Machine Learning, and Others), Software Tools (Facial ... Areas, End Users,and Regions - Global forecast ... --> http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) has ...
(Date:2/2/2016)... NEW YORK , Feb. 2, 2016 /PRNewswire/ ... analysis of the bioinformatic market by reviewing the ... computer enabled tools that drive the field forward. ... report to: Identify the challenges and opportunities ... service providers and software solution developers, as well ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... (PRWEB) , ... February 08, 2016 , ... ... p.m. , Location: Baruch S. Blumberg Institute at the Pennsylvania Biotechnology Center of ... Blumberg Institute and The Commonwealth Medical College (TCMC) will hold an open house ...
(Date:2/9/2016)... , ... February 09, 2016 , ... Tunnell Consulting, Inc. ... Based in Paris, he will focus on acquiring new accounts and work closely with ... , “Fred brings to our European clients more than 15 years of ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... for Public Policy for the National Organization for Rare Disorders (NORD). Dorman will ... ensure their voices are heard throughout the drug regulatory review process. , “Adding ...
(Date:2/9/2016)... LONDON , February 9, 2016 ... replace paper and protect IP   E-WorkBook ... will be rolled out in Germany ... and protect valuable IP. Users will be able to search ... or experiment as part of the application, to boost collaboration ...
Breaking Biology Technology: