Navigation Links
Tiny details in three dimensions
Date:2/13/2009

They are borne by ticks and can cause acute and chronic symptoms in joints, muscles and the nervous system the bacteria that cause Lyme borreliosis, which 80,000 people in Germany contract every year. Heidelberg researchers have now succeeded in identifying their structure more accurately. Using a cryo-tomography microscope, the previously unknown detailed structure of the spirochete bacteria can be shown in three dimensions. One finding that borrelia types in North America more often affect the joints and in Europe the skin and nervous system as well seems to stem from the characteristics of their motility system.

The research group headed by Professor Reinhard Wallich, Institute of Immunology, and Dr. Friedrich Frischknecht, Department of Parasitology at the Hygiene Institute of Heidelberg University Hospital has published its findings in cooperation with colleagues from Munich and Freiburg in "Molecular Microbiology". Among other things, the researchers hope to gain new insights into the various clinical symptoms of the disease.

Shock freezing maintains original condition / Resolution up to 5 nanometers

In cryo-electron tomography the organism is shock frozen so that its original condition is retained. Chemical pretreatment, which is often associated with modifying structures and properties, is no longer necessary. Resolution of five to seven nm allows tiniest structures to be viewed. "The new technology is a quantum leap for research, comparable with the step from simple x-ray images to three-dimensional computer tomography in clinical diagnostics," stated Dr. Frischknecht.

The bacteria have developed many strategies to avoid the immune response of humans. Borrelias, like the syphilis pathogens, are spirochetes bacteria. The spiral-shaped, actively motile bacteria have flexible, pliable bodies that are moved with the aid of complex organs, flagella. A correlation between the motility and infectiousness of the pathogen has long been presumed.

The Heidelberg researchers have now for the first time compared the characteristics of the three human pathogenic species that cause Lyme borreliosis that occur in Europe and cause varying symptoms. While in North America, the major symptom is joint inflammation, in Europe, the skin or nervous system may also be affected. With the aid of cryo-tomographic microscopy, they have successfully shown that the three pathogen types have varying numbers of flagella. In addition, structures were identified for the first time that could play an important role in the reproduction of the bacteria.


'/>"/>

Contact: Dr. Friedrich Frischknecht
freddy.frischknecht@med.uni-heidelberg.de
49-622-156-6537
University Hospital Heidelberg
Source:Eurekalert  

Related biology news :

1. Biochemists reveal details of mysterious bacterial microcompartments
2. Researchers uncover details about how dietary restriction slows down aging
3. Study reveals surprising details of the evolution of protein translation
4. Details of evolutionary transition from fish to land animals revealed
5. Three-way mating game of North American lizard found in distant European relative
6. Columbia to award 2007 Horwitz Prize to three generations of teacher-student scientists
7. Stevens researchers provide oversight for three-year mariculture program in Egypt and Israel
8. Three Dimensional Visualization of Right Ventricle Provides Important Information for Treatment of Patients with Tetralogy of Fallot, According to a Study in The American Journal of Cardiology
9. Researchers document rapid, dramatic reverse evolution in the threespine stickleback fish
10. Scientists integrate data in three dimensions to study climate effects on young fish
11. Wetlands expert: China should think outside the flooding box with Three Gorges Dam
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tiny details in three dimensions
(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of the medical ... premium product recently added to the range of products distributed by Ampronix. ... ... ... Ampronix News ...
(Date:5/20/2016)... 2016  VoiceIt is excited to announce its ... By working together, VoiceIt and VoicePass will ... VoicePass take slightly different approaches to voice biometrics, ... and usability. ... partnership. "This marketing and technology partnership ...
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... ... May 24, 2016 , ... Last week, Callan Capital, ... executives and entrepreneurs, held The Future of San Diego Life Science event at the ... life science community attended the event with speakers Dr. Rich Heyman, former CEO of ...
(Date:5/23/2016)... Texas (PRWEB) , ... May 23, 2016 , ... The need for blood donations in ... this week by the South Texas Blood & Tissue Center, blood donations are on the ... 30 years, and they are down 21 percent in South Texas in the last four ...
(Date:5/23/2016)... WARSAW, Ind. , May 23, 2016 Zimmer ... in musculoskeletal healthcare, today announced that its Board of Directors ... stockholders for the second quarter of 2016. ... on or about July 29, 2016 to stockholders of record ... Future declarations of dividends are subject to approval of the ...
(Date:5/23/2016)... LONDON , May 23, 2016 - ... by 40% - Frontage Implement a Single Platform to ... Compliance and Traceability Within the Bioanalytical lab Frontage Laboratories, ... the United States and China , ... its laboratory facilities. In addition to serving as the global electronic ...
Breaking Biology Technology: