Navigation Links
Tiny details in three dimensions
Date:2/13/2009

They are borne by ticks and can cause acute and chronic symptoms in joints, muscles and the nervous system the bacteria that cause Lyme borreliosis, which 80,000 people in Germany contract every year. Heidelberg researchers have now succeeded in identifying their structure more accurately. Using a cryo-tomography microscope, the previously unknown detailed structure of the spirochete bacteria can be shown in three dimensions. One finding that borrelia types in North America more often affect the joints and in Europe the skin and nervous system as well seems to stem from the characteristics of their motility system.

The research group headed by Professor Reinhard Wallich, Institute of Immunology, and Dr. Friedrich Frischknecht, Department of Parasitology at the Hygiene Institute of Heidelberg University Hospital has published its findings in cooperation with colleagues from Munich and Freiburg in "Molecular Microbiology". Among other things, the researchers hope to gain new insights into the various clinical symptoms of the disease.

Shock freezing maintains original condition / Resolution up to 5 nanometers

In cryo-electron tomography the organism is shock frozen so that its original condition is retained. Chemical pretreatment, which is often associated with modifying structures and properties, is no longer necessary. Resolution of five to seven nm allows tiniest structures to be viewed. "The new technology is a quantum leap for research, comparable with the step from simple x-ray images to three-dimensional computer tomography in clinical diagnostics," stated Dr. Frischknecht.

The bacteria have developed many strategies to avoid the immune response of humans. Borrelias, like the syphilis pathogens, are spirochetes bacteria. The spiral-shaped, actively motile bacteria have flexible, pliable bodies that are moved with the aid of complex organs, flagella. A correlation between the motility and infectiousness of the pathogen has long been presumed.

The Heidelberg researchers have now for the first time compared the characteristics of the three human pathogenic species that cause Lyme borreliosis that occur in Europe and cause varying symptoms. While in North America, the major symptom is joint inflammation, in Europe, the skin or nervous system may also be affected. With the aid of cryo-tomographic microscopy, they have successfully shown that the three pathogen types have varying numbers of flagella. In addition, structures were identified for the first time that could play an important role in the reproduction of the bacteria.


'/>"/>

Contact: Dr. Friedrich Frischknecht
freddy.frischknecht@med.uni-heidelberg.de
49-622-156-6537
University Hospital Heidelberg
Source:Eurekalert  

Related biology news :

1. Biochemists reveal details of mysterious bacterial microcompartments
2. Researchers uncover details about how dietary restriction slows down aging
3. Study reveals surprising details of the evolution of protein translation
4. Details of evolutionary transition from fish to land animals revealed
5. Three-way mating game of North American lizard found in distant European relative
6. Columbia to award 2007 Horwitz Prize to three generations of teacher-student scientists
7. Stevens researchers provide oversight for three-year mariculture program in Egypt and Israel
8. Three Dimensional Visualization of Right Ventricle Provides Important Information for Treatment of Patients with Tetralogy of Fallot, According to a Study in The American Journal of Cardiology
9. Researchers document rapid, dramatic reverse evolution in the threespine stickleback fish
10. Scientists integrate data in three dimensions to study climate effects on young fish
11. Wetlands expert: China should think outside the flooding box with Three Gorges Dam
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tiny details in three dimensions
(Date:5/9/2016)... 2016 Elevay is currently known ... freedom for high net worth professionals seeking travel for ... connected world, there is still no substitute for a ... sealing your deal with a firm handshake. This is ... advantage of citizenship via investment programs like those offered ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) ... financial services, but it also plays a fundamental part in ...
(Date:4/26/2016)... and LONDON , April 26, ... of EdgeVerve Systems, a product subsidiary of Infosys ... announced a partnership to integrate the Onegini mobile ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... customers enhanced security to access and transact across ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016  Blueprint Bio, a company dedicated ... the medical community, has closed its Series A funding ... . "We have received a commitment from ... we need to meet our current goals," stated ... the runway to complete validation on the current projects ...
(Date:6/23/2016)... Francisco, CA (PRWEB) , ... June 23, 2016 ... ... (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase its ... Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical ...
(Date:6/23/2016)... 2016  Amgen (NASDAQ: AMGN ) today ... life sciences incubator to accelerate the development of ... space at QB3@953 was created to help high-potential life ... many early stage organizations - access to laboratory infrastructure. ... launched two "Amgen Golden Ticket" awards, providing each winner ...
(Date:6/22/2016)... Research and Markets has announced the addition ... their offering. The global ... billion in 2013. The market is expected to grow at a ... 2020, increasing from $50.6 billion in 2015 to $96.6 billion in ... forecast period (2015 to 2020) are discussed. As well, new products ...
Breaking Biology Technology: