Navigation Links
Tiny DNA pyramids enter bacteria easily -- and deliver a deadly payload
Date:7/9/2014

Bacterial infections usually announce themselves with pain and fever but often can be defeated with antibiotics and then there are those that are sneaky and hard to beat. Now, scientists have built a new weapon against such pathogens in the form of tiny DNA pyramids. Published in the journal ACS Applied Materials & Interfaces, their study found the nanopyramids can flag bacteria and kill more of them than medicine alone.

David Leong, Jianping Xie and colleagues note that some infectious pathogens can lie in wait, undetectable in the human body or in places that antibiotics have a hard time accessing. Engineered nanomedicine offers a new way to deliver drugs directly into bacterial cells, but the carriers developed so far pose problems such as toxicity. So Leong's team decided to use DNA to build a better, safer drug-delivery tool.

They made little pyramids out of DNA that were so small that thousands could fit in the period at the end of this sentence. Then, they attached gold nanomaterials as fluorescent tags and also packaged the drug actinomycin D (AMD) into the struts of the DNA pyramids. In tests on the common bacteria Escherichia coli and Staphylococcus aureus, the scientists tracked the nanopyramids as they entered the cells and released the drug payload. This killed 65 percent of the S. aureus and 48 percent of the E. coli, compared to 42 percent and 14 percent with AMD alone.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. UC Riverside to lead new Energy Frontier Research Center project
2. $2.4 million NIH center grant to develop a cleaner, healthier environment in Detroit
3. UK Superfund Research Center receives $12.2 million federal grant
4. Clemson, Greenwood Genetic Center research into autism, cancer funded by Self Healthcare
5. Chapman University partners with the Center for Autism and Related Disorders
6. University of Chicago chosen as a center for new cancer clinical trials network
7. News from the Journal of Parenteral and Enteral Nutrition -- JPEN -- May 2014
8. Jerry Melillo of MBL Ecosystems Center elected to National Academy of Sciences
9. New Translational Addiction Sciences Center poised to make headway in treatment of addiction
10. News from the Journal of Parenteral and Enteral Nutrition (JPEN) April 2014
11. Beth Israel Deaconess Medical Centers Harold F. Dvorak, M.D., wins Gairdner Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... , ... May 25, 2017 , ... ... the full process behind each occurrence. Live cell imaging using fluorescence microscopy is ... the use of automated fluorescence microscopy methods will be discussed, from small animal ...
(Date:5/24/2017)... ... 23, 2017 , ... Federal funding for basic and applied scientific research — ... and other vital technologies — deserves continued support, say leaders of SPIE, the ... today in responding to the President’s budget request for Fiscal Year 2018. , The ...
(Date:5/23/2017)... Yorba Linda, Ca (PRWEB) , ... ... ... stem cells (PSCs) offer an unlimited source of human cardiovascular cells for ... efficient cardiac-directed differentiation methods makes it possible to generate large numbers of ...
(Date:5/23/2017)... , ... May 23, 2017 , ... ... advanced technology applications, has announced a facility expansion to accommodate its rapid growth. ... feet of new workspace and renovation of the existing areas. The expansion includes, ...
Breaking Biology Technology: