Navigation Links
Timely technology sees tiny transitions
Date:6/23/2010

like "sensing volume," the dielectric environment in which changes can be read by a spectrometer.

Hafner and his colleagues borrowed bioconjugate chemistry techniques, coating the bipyramids with antibodies and then adding antigens that strongly bind to them. Then the antigens were rinsed off. Whenever one was released from its bond to the bipyramid antibody, the researchers detected a slight shift toward the blue in the red light naturally scattered by gold bipyramids.

The process is "label-free," meaning the molecule itself is being detected, rather than a fluorescent tag that requires modification of the molecule, Hafner said. Also, the dielectric property being detected is permanent, so molecules could be tracked for more than 10 hours, as compared with only minutes with current methods.

"The ability to measure over long time scales opens the possibility to study systems with strong affinity at the single-molecule limit, such as lectin-carbohydrate interactions responsible for cell recognition and adhesion," Hafner said. "Other single-molecule methods based on fluorescence are limited by photo bleaching, and those based on force measurements are limited by radiation damage and mechanical instabilities."

Work needs to be done before LSPR becomes an ideal biological sensor, he said. The team plans to tweak the bipyramids and will test other particles.

"With this bipyramid, we went a little too red," he said. "It's a compromise. Make them long and they're really sensitive, but so red that we don't get much signal. Make them shorter, they're somewhat less sensitive but you have more signal.

"If we can get the signal-to-noise ratio up by a factor of two or three, we think it will be a powerful method for biological research."


'/>"/>

Contact: David Ruth
druth@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gold Standard/Elsevier offers timely, reliable drug pricing data, including average wholesale price
2. Free Webinar to Focus on Commercializing University Technology
3. Conference to discuss sensing technology developments and opportunities
4. Michael Graetzel wins the Millennium Technology Prize
5. Success with cisgenics in forestry offers new tools for biotechnology
6. Massive resources now directed at sustainable animal waste technology
7. Field Museum technology project wins prestigious award
8. Cutting-edge vaccine research to be showcased at AAPS National Biotechnology Conference
9. Biotherapeutic Innovations on Display at AAPS National Biotechnology Conference
10. Space technology revolutionizes archaeology, understanding of Maya
11. New LLNL detection technology identifies bacteria, viruses, other organisms within 24 hours
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... , April 2, 2015 ... Q1 2015 attributed to somewhat higher than 125 MSEK. ... the year-end report 2014 that revenues for Q1 2015 ... the company reported for Q4 2014. The operating result ... be negative. The complete interim report will as previously ...
(Date:3/31/2015)...  Elephant Talk Communications Corp. (NYSE MKT: ETAK) ("Elephant ... Defined Network Architecture (ET Software DNA® 2.0) platforms and ... $20.4 million for the year ended December 31, 2014 ... year ended December 31, 2013. At ... its multi-year transition away from its legacy landline business ...
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... the "Global Iris Recognition Market 2015-2019" report ... Global Iris Recognition market to grow at a CAGR ... This report covers the present scenario and the growth ... period 2015-2019. To calculate the market size, the report ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... disabilities who are struggling to regain the use of ... engineers and students from Rochester Institute of Technology. ... the human body, to improve the performance of external ... disabilities, such as strokes or major spinal cord injuries, ...
... know all there is to know about Escherichia coli, ... has more than four thousand genes, and the functions ... Siegele, a biology professor at Texas A&M University whose ... , Harmless E. coli strains are normally found in ...
... Understanding, through its Institute for Arctic Studies, has ... Science Foundation through its Integrative Graduate Education and ... grant supports the development of an interdisciplinary doctoral ... a focus on rapid environmental change. "This grant ...
Cached Biology News:Robotics research: Enhancing the lives of people with disabilities 2GIANT-Coli: A novel method to quicken discovery of gene function 2Dartmouth awarded NSF grant for new polar sciences, engineering grad program 2Dartmouth awarded NSF grant for new polar sciences, engineering grad program 3
(Date:5/4/2015)... , May 4, 2015 China Cord Blood ... China,s leading provider of cord ... stem cell storage services, today announced that the Company ... Meditech"), a Hong Kong listed ... entered into an agreement (the "Agreement") to purchase the ...
(Date:5/4/2015)... Wheaton, Illinois (PRWEB) May 04, 2015 ... treatment options for patients with arm and hand ... rehabilitation exoskeleton at its Oakbrook Terrace network site. ... foundation, the Armeo®Spring is a highly-regarded treatment option ... In acquiring the Armeo®Spring, Marianjoy becomes one of ...
(Date:5/1/2015)... /CNW/ - Softchoice, a leading North American IT solutions and managed ... of two Cisco® Partner Summit Country awards. ... Security Partner of the Year for Canada ... in Montreal . "We ... awards at this year,s conference," said David MacDonald , ...
(Date:5/1/2015)... and RESEARCH TRIANGLE PARK, N.C. , ... ) announced today that Roger Jeffs , Ph.D., President ... overview and update on the company,s business at the Deutsche ... Boston, Massachusetts . The presentation will ... Eastern Time, and can be accessed via a live webcast ...
Breaking Biology Technology:China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 2China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 3Marianjoy Acquires Armeo®Spring Arm and Hand Rehabilitation Exoskeleton at Oakbrook Terrace Facility 2Softchoice recognized with two Country Awards at Cisco Partner Summit 2015 2
... Texas, June 22, 2011 Five exceptional oncology ... McKesson Specialty Care Solutions | US Oncology ... their patients. The Excellence in Oncology Nursing Award honors those ... who exemplify competency, courage and determination in providing the highest ...
... June 22, 2011 The Roche manuscript: "Immunoglobulin Domain ... Bispecific IgG Antibodies" has been published in the prestigious ... USA (PNAS). Corresponding authors are Wolfgang Schaefer, ... and Christian Klein, Head of Oncology Programs, Discovery Oncology ...
... June 22, 2011 VENENUM Biodesign, a drug discovery ... compound collection to identify potential therapeutic agents against its ... that it opened its new medicinal chemistry space at ... The facility comprises over 11,000 square feet of ...
Cached Biology Technology:McKesson Specialty Care Solutions | US Oncology Honors Five Exceptional Oncology Nurses for Outstanding Work 2McKesson Specialty Care Solutions | US Oncology Honors Five Exceptional Oncology Nurses for Outstanding Work 3McKesson Specialty Care Solutions | US Oncology Honors Five Exceptional Oncology Nurses for Outstanding Work 4Proceedings of the National Academy of Sciences (PNAS) Publishes Roche Manuscript on Production of Bispecific IgG Antibodies 2VENENUM Biodesign Announces Opening of Medicinal Chemistry Labs 2
SHEEP ANTI FLECAINIDE...
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
REGULATED IN DEVELOPMENT AND DNA DAMAGE RESPONSES 1,HIF-1 responsive RTP801...
Biology Products: