Navigation Links
Timely technology sees tiny transitions
Date:6/23/2010

like "sensing volume," the dielectric environment in which changes can be read by a spectrometer.

Hafner and his colleagues borrowed bioconjugate chemistry techniques, coating the bipyramids with antibodies and then adding antigens that strongly bind to them. Then the antigens were rinsed off. Whenever one was released from its bond to the bipyramid antibody, the researchers detected a slight shift toward the blue in the red light naturally scattered by gold bipyramids.

The process is "label-free," meaning the molecule itself is being detected, rather than a fluorescent tag that requires modification of the molecule, Hafner said. Also, the dielectric property being detected is permanent, so molecules could be tracked for more than 10 hours, as compared with only minutes with current methods.

"The ability to measure over long time scales opens the possibility to study systems with strong affinity at the single-molecule limit, such as lectin-carbohydrate interactions responsible for cell recognition and adhesion," Hafner said. "Other single-molecule methods based on fluorescence are limited by photo bleaching, and those based on force measurements are limited by radiation damage and mechanical instabilities."

Work needs to be done before LSPR becomes an ideal biological sensor, he said. The team plans to tweak the bipyramids and will test other particles.

"With this bipyramid, we went a little too red," he said. "It's a compromise. Make them long and they're really sensitive, but so red that we don't get much signal. Make them shorter, they're somewhat less sensitive but you have more signal.

"If we can get the signal-to-noise ratio up by a factor of two or three, we think it will be a powerful method for biological research."


'/>"/>

Contact: David Ruth
druth@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gold Standard/Elsevier offers timely, reliable drug pricing data, including average wholesale price
2. Free Webinar to Focus on Commercializing University Technology
3. Conference to discuss sensing technology developments and opportunities
4. Michael Graetzel wins the Millennium Technology Prize
5. Success with cisgenics in forestry offers new tools for biotechnology
6. Massive resources now directed at sustainable animal waste technology
7. Field Museum technology project wins prestigious award
8. Cutting-edge vaccine research to be showcased at AAPS National Biotechnology Conference
9. Biotherapeutic Innovations on Display at AAPS National Biotechnology Conference
10. Space technology revolutionizes archaeology, understanding of Maya
11. New LLNL detection technology identifies bacteria, viruses, other organisms within 24 hours
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... Deutschland und GERMANTOWN, Maryland , June ... ®   Produktlinie mit DNA-Tests verbessert den ... (NASDAQ: QGEN ; Frankfurt Prime Standard: QIA) hat ... STR-Testkits der Produktlinie Investigator ® ... Markt eingeführt. Die neuen Kits zur Erstellung genetischer Fingerabdrücke ...
(Date:6/17/2015)... , June 17, 2015  Crossmatch™, a leading ... that its U.are.U ® 4500 fingerprint readers ... Eateries, Inc., a San Jose, ... to increase security, improve accountability and reduce fraud ... instant, non-repudiable identity confirmation for employee sign in ...
(Date:6/16/2015)... Fingerprint Cards has received an order of 375 ... from one of its module partners in Asia ... the third quarter 2015. The sensors will be used by ... Jörgen Lantto, CEO of FPC, comments: " This order   ... smartphone OEMs in integrating touch fingerprint sensors in   their ...
Breaking Biology News(10 mins):QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2
... Persistence paid off for a University of Alberta paleontology researcher, who ... finally identified it as a new species of pterosaur, a flying ... says she was stumped when the small piece of jaw bone ... the U of A,s paleontology department. "It could have been ...
... Research by engineers and cancer biologists at Virginia ... provide a new way to screen breast cancer ... their work provided to Biomaterials was ... images published in the journal,s 2010 catalogue. ...
... Although the 2009 H1N1 influenza pandemic infected an ... in the United States, it also brought one significant ... protect against multiple strains of influenza. In the ... Experimental Medicine , researchers from the University of Chicago ...
Cached Biology News:Early investigations promising for detecting metastatic breast cancer cells 2Early investigations promising for detecting metastatic breast cancer cells 3Early investigations promising for detecting metastatic breast cancer cells 4H1N1 pandemic points to vaccine strategy for multiple flu strains 2H1N1 pandemic points to vaccine strategy for multiple flu strains 3
(Date:7/7/2015)... ... July 07, 2015 , ... An aging population, ... of the factors driving the pharmaceutical contract manufacturing market. BCC Research reveals in ... manufacturing organizations (CMOs), are driving market growth. Drug manufacturers are increasing their outsourcing ...
(Date:7/7/2015)... CA (PRWEB) , ... July 07, 2015 , ... ... American Business Women’s Association, offering an exclusive scholarship opportunity for women across the country ... working, committed individual as they continue their education,” said Rochelle Schwartz, Founder of 4MD ...
(Date:7/7/2015)... July 7, 2015  In the farthest reaches of ... the Matsés tribe came together in a quest to ... The gathering, held in May in a remote village ... Brazil , concluded over two years work and ... Encyclopedia ever written by an Amazonian tribe. The 500-page ...
(Date:7/7/2015)... DEARBORN, Mich. , July 7, 2015  SME,s ... for its third-annual "30 Under 30" issue, celebrating young ... in manufacturing. The July issue of ... young manufacturing professionals and students for their accomplishments. Among ... with the U.S. Air Force on optimizing the topology ...
Breaking Biology Technology:More Drug Companies Increasing Outsourcing Budgets; CMO Partners Spring Up as Market Thrives, According to BCC Research 2More Drug Companies Increasing Outsourcing Budgets; CMO Partners Spring Up as Market Thrives, According to BCC Research 34MD Medical Announces $2,000 Scholarship Opportunity in Conjunction with American Business Women’s Association (ABWA) 24MD Medical Announces $2,000 Scholarship Opportunity in Conjunction with American Business Women’s Association (ABWA) 3Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 2Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 3Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 4SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 2SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 3SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 4SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 5
... ACUSON S2000 Ultrasound System Dramatically Enhances the Way Ultrasound, Departments ... ... Applications, CHICAGO, Nov. 26 ... of North America (RSNA) from,Nov. 25 to 30 at McCormick Place ...
... Disparate PACS and RIS Systems Simultaneously to ... ... RSNA Booth #5924 -- Compressus Inc.,makers of the ... devices, PACS, HIS, RIS,and related information systems, announced today ...
... H2Diesel Holdings, Inc. (OTC,Bulletin Board: HTWO) today announced ... effective December 1, 2007., Since 2004, Mr. Claiborne ... where he led the Company,s finance and,information technology organizations ... of the Board and CEO. From 2001 to 2004, ...
Cached Biology Technology:Siemens' New S Class Revolutionizes the Paradigm of Ultrasound Workflow Today and Tomorrow 2Siemens' New S Class Revolutionizes the Paradigm of Ultrasound Workflow Today and Tomorrow 3Siemens' New S Class Revolutionizes the Paradigm of Ultrasound Workflow Today and Tomorrow 4Siemens' New S Class Revolutionizes the Paradigm of Ultrasound Workflow Today and Tomorrow 5Siemens' New S Class Revolutionizes the Paradigm of Ultrasound Workflow Today and Tomorrow 6E-Rad Solutions Selects Compressus' Enterprise Systems Integration Technology to Fuel Entry Into Teleradiology Market 2E-Rad Solutions Selects Compressus' Enterprise Systems Integration Technology to Fuel Entry Into Teleradiology Market 3H2Diesel Announces Appointment of Cary J. Claiborne as Chief Financial Officer 2H2Diesel Announces Appointment of Cary J. Claiborne as Chief Financial Officer 3
... description: self locking design in ice/water ... new product number, created to easily ... no availability yet, please order under ... contact customer service for assistance. ID ...
Membrane Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z71,523-9) ... assistance. ID clarifier: reusable vial ...
This modular laminar flow hood forces air through a 99.99% efficient HEPA filter to create a clean processing area. Configurations are available with vertical or horizontal flow; options include a wo...
Biology Products: