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Tick tock: Rods help set internal clocks, biologist says
Date:9/17/2010

ically photosensitive retinal ganglion cells -- both of them light-sensitive cells in the animals' retinas -- were not functional. The team then exposed the rodents to varying intensities of light, measuring the animals' responding level of activity by how often they ran on hamster wheels.

The study results are important because they indicate that prolonged exposure to dim or low light at night (such as that in homes and office buildings) can influence mammals' biological clocks and "throw off" their sleep-wake cycles. Hattar suggested that one way people can mitigate this effect is to make sure to get some exposure to bright day light every day. (The exposure to brighter, natural daylight will firmly reset the clocks to a proper asleep-at-night-awake-in-the-day cycle.)

In addition, the study has possible implications for older people being cared for in nursing homes and hospitals, he said.

"Older adults often lose their rod cells to age, which means that their caretakers would be well advised to regularly and deliberately expose them to bright natural daylight in order to make sure that their natural, biological rhythms remain in sync so their sleep-wake cycles remain accurately set," Hattar said. "Otherwise, they could have sleep disturbances, such as intermittent waking or difficulty falling asleep, not to mention the impact on their appetite and other bodily functions."


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Contact: Lisa DeNike
Lde@jhu.edu
443-287-9960
Johns Hopkins University
Source:Eurekalert

Page: 1 2

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