Navigation Links
Thymoquinone induced oxidative stress targets highly aggressive prostate cancers
Date:6/1/2010

rapeutic utility as an adjunct to anti-tumor therapy. Indeed, in a previous publication (Exp Biol Med; (2009) Apr; 234(4) :442-53) we had shown that at lower concentrations (<5.0 M) TQ decreases ROS production and increases GSH levels in pancreatic beta-cells, which restored nelfinavir (an anti-HIV agent) induced deleterious effects on these cells. Our current findings suggest that the ROS generating effects of high concentrations of TQ (>20 M) may be of great advantage towards the development of novel anti-cancer therapeutics, especially against hormone-refractory prostate cancers which are much harder to treat."

The research team led by Dr. Krishna C. Agrawal (posthumously) included Dr. Sandeep Koka, previously a graduate student under Dr. Agrawal, and two other faculty members from Tulane University, Dr. Asim B. Abdel-Mageed and Dr. Debasis Mondal. These investigators successfully tested the hypothesis that TQ induced oxidative stress is responsible for its anti-proliferative effects in prostate cancer cells. Since black seed oil have been used in the middle eastern countries for hundreds of years, the investigators postulated that the active component TQ and possibly the oil itself, can be used effectively, either alone or as an adjunct to chemotherapy, to target highly aggressive prostate cancers.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "Koka et al have demonstrated that Thymoquinone efficiently killed hormone-dependent and hormone-independent prostate cancer cells. The mechanism appears to be that Thymoquinone induces oxidative stress and suppresses GSH levels. This suggests that oxidative stress may lead to decreased tumor growth and increased cell death in highly aggressive forms of prostate cancer."


'/>"/>

Contact: Dr. Debasis Mondal
dmondal@tulane.edu
504-988-4668
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
2. Folate prevents alcohol-induced congenital heart defects in mice
3. Cerner and ISAEC to collaborate on genetic studies of drug-induced serious adverse events
4. Gene silencing may be responsible for induced pluripotent stem cells limitations
5. Novel strategy for generating induced pluripotent stem cells for clinical use is safe and efficient
6. Induced neural stem cells: Not quite ready for prime time
7. Tummy troubles -- gastrin key in bacterial-induced stomach cancer
8. Simple drug treatment may prevent nicotine-induced SIDS: Study
9. Researchers engineer metabolic pathway in mice to prevent diet-induced obesity
10. International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury
11. Did the North Atlantic fisheries collapse due to fisheries-induced evolution?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 31, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market and creator of ... provisional patent 62/198989 for ELECTRONIC CRYPTO-CURRENCY MANAGEMENT ... method to advance crypto-currencies such as Bitcoin into the ... uniform way to manage all payments.  ...
(Date:7/23/2015)... 2015 Aware, Inc. (NASDAQ: AWRE ), a ... results for its second quarter ended June 30, 2015.  ... $4.5 million, a decrease of 33% compared to $6.8 million ... second quarter of 2015 was $0.3 million, or $0.01 per ... diluted share, in the same period a year ago.  ...
(Date:7/20/2015)... , July 20, 2015  Acuity Market Intelligence,s ... The Convergence of Commerce and Privacy" forecasts that ... biometric apps will be downloaded to smart mobile ... mobile biometrics market is projected to generate more ... during the seven-year forecast period.    ...
Breaking Biology News(10 mins):NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2
... is the role of the research university today center ... ground for future leaders?, Are research universities prepared for the ... falling behind in the global innovation race? , People are ... flowing? , What is the impact of the fiscal crisis ...
... the Franconian Jura evokes associations with a pet cemetery, for ... It also poses an intriguing question: Were all dinosaurs dressed ... newly hatched when it met its end, is remarkable in ... the dinosaur fossil record, so every new discovery provides insights ...
... of Nottingham are leading research that will develop the world,s ... with colleagues in South Korea, the project aims to build ... taking into account the differences and variations which occur from ... could be used to help doctors in countries like South ...
Cached Biology News:All Things Research 2012 roundtable discussion 2Feathered saurians -- downy dinosaur discovered 2Road-mapping the Asian brain 2
(Date:7/30/2015)... , July 30, 2015   Aratana Therapeutics, ... therapeutics company focused on the licensing, development and ... today announced that its strategic partner VetStem Biopharma, ... confirmation study of AT-016, an adipose-derived allogeneic stem ... treatment of osteoarthritis pain in dogs. ...
(Date:7/30/2015)... DALLAS , July 30, 2015  With over 60,000 customers across the globe, ISN ... helps connect 450 hiring organizations with more than 60,000 safe and reliable contractors in over 80 ... ... ... Headquartered in Dallas, ...
(Date:7/30/2015)... HIGHLIGHTS:Q2 2015 Results (all changes are against the ... $697 million compared to $701 million in the second ... changes in foreign currency exchange rates decreased sales by ... By business unit, organic sales growth was 6% in ... , Reported diluted EPS was $0.98 compared to ...
(Date:7/30/2015)... ... , ... As part of its 2015 growth plan and as a follow up to the ... units, Whitehouse Laboratories is pleased to announce that it has begun construction on a new ... and will be strictly dedicated to basic USP 51, USP 61, and USP 62 testing ...
Breaking Biology Technology:Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 2Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 4Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 5Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 6Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 7Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 8Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 9Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 10Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 11Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 12Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 13Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 14Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 15Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 16Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 17Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 18Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 19Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 20Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2
... Surgeons launched its revolutionary Trusted LASIK Surgeons directory service ... provide a resource for consumers seeking to improve their ... help improve their chances of attaining 20-20 vision. ... a unique screening process ensuring that only those who ...
... -- WuXi PharmaTech (Cayman) Inc.,(NYSE: WX ... serving the,pharmaceutical, biotechnology, and medical device industries, with ... its financial results for,fourth-quarter and full-year 2008. , ... Highlights, -- ...
... (Nasdaq: ISIS ), the leader in antisense therapeutics, ... Citi,s 4th Annual Biotech Day on Wednesday, April 1, 2009, ... Center in New York, NY. A live audio webcast ... section of the Company,s Web site, www.isispharm.com . ...
Cached Biology Technology:Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 2Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 3Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 4Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 5Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 6Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 7Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 8WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 2WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 3WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 4WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 5WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 6WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 7WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 8WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 9WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 10WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 11WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 12WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 13WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 14WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 15WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 16WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 17WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 18WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 19WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2008 Results 20
Mouse monoclonal antibody raised against a partial recombinant ALAS2. NCBI Entrez Gene ID = ALAS2...
96-well format (For processing samples on microplate-size MALDI target plates such as those from Bruker, Shimadzu, Thermo, and PerkinElmer) Packaging: 2 / pack...
Mouse monoclonal antibody raised against a partial recombinant CENTB2. NCBI Entrez Gene ID = CENTB2...
...
Biology Products: