Navigation Links
Thumbs up -- a tiny ancestral remnant lends developmental edge to humans
Date:9/4/2008

WALNUT CREEK, Calif. Subtle genetic changes that confer an evolutionary advantage upon a species, such as the dexterity characteristic of the human hand, while difficult to detect and even harder to reproduce in a model system, have nevertheless generated keen interest amongst evolutionary biologists. In findings published online in the September 5 edition of the journal Science, researchers from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and their collaborators, have uncovered a specifically human 13-nucelotide change concealed in the vast three-billion-letter landscape of the human genome. Their experiments reveal this stretch of DNA to be a recently evolved regulator of gee expression that, when introduced into a mouse embryo system, influence the molecular machinery to yield human limb and thumb development patterns.

The study reinforces the conclusion that certain regions of genomesthose which are conserved across many species over evolutionary time and do not encode genescan have a powerful regulatory influence on gene expression or the production of proteins.

"The study points to how human nucleotide substitutions can alter the regulation of genes in humans distinct from that of non-human primates, such as chimps," said one of the study's corresponding/senior authors Eddy Rubin, Director of Berkeley Lab's Genomics Division and the U.S. Department of Energy Joint Genome Institute. "This highlights a strategy that could be applied across the genome to understand at a molecular level what leads to differences between humans and non-human primates."

The goal of the experiment was not to produce mice with human fingers. Rather, an indirect assay was employed to test the expression readout of a single human genetic fragment and compare it with the chimp version. The strategy, which links a color-inducing reporter gene when expression is activated, turns the targeted tissue blu
'/>"/>

Contact: David Gilbert
degilbert@lbl.gov
925-296-5643
DOE/Joint Genome Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetic ancestral testing cannot deliver on its promise, study warns
2. Clues to ancestral origin of placenta emerge in Stanford study
3. Engineers create bone that blends into tendons
4. Old developmental pathways spawn revolutionary evolutionary changes
5. Researchers find association between food insecurity and developmental risk in children
6. Research pioneer in the developmental origins of psychiatric illness is awarded the Sackler prize
7. RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols
8. Pediatricians alerted to the developmental nature of underage drinking in special journal supplement
9. IVF does not increase risk of developmental disorders in children
10. Gene regulation, not just genes, is what sets humans apart
11. Humans fostering forest-destroying disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... Calif. , Dec. 4, 2014 ... has boosted investments in new testing and inspection ... also given rise to a range of innovative ... the requirements of Generation Y, which is generally ... As a result, product development strategies of test ...
(Date:11/21/2014)... , November 18, 2014 According ... Market by Systems (Video, RFID, Access Control, Intrusion Detection, ... Hotels, Banks, Government), Component Service Geography - Global Forecasts ... Market is projected to be around $25 Billion in ... 2020, growing at a CAGR of 8.69%. ...
(Date:11/18/2014)... 18, 2014  The Secure Identity & Biometrics ... jointly announce the formation of The Airport Entry ... Identity and Biometric Entry and Exit Solutions ... official support from BORDERPOL, the international non-profit organization ... provide expertise regarding border security, traveler and migration ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... women have twice the risk of preterm delivery than ... a new study by the Kaiser Permanente Division of ... University Press,s journal Human Reproduction on behalf ... The study found that pregnant women with symptoms ...
... Palm Vein Authentication Technology Integrates with,Citrix Password ... and,Compliance, SUNNYVALE, Calif., Oct. 22 ... supplier of innovative computer products including,hard disk ... that its PalmSecure LOGONDIRECTOR has been verified ...
... University, along with colleagues from the California Institute of ... other institutions, have unearthed crystalline magnetic fossils of a ... boundary of the Paleocene and Eocene epochs, some 55 ... in the Proceedings of the National Academy of ...
Cached Biology News:Depression during pregnancy can double risk of preterm delivery 2Fujitsu PalmSecure LOGONDIRECTOR Verified as Citrix Ready 2Fujitsu PalmSecure LOGONDIRECTOR Verified as Citrix Ready 3Fujitsu PalmSecure LOGONDIRECTOR Verified as Citrix Ready 4Earlier global warming produced a whole new form of life 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... DURHAM, N.C., Oct. 26 Oxygen Biotherapeutics, Inc. (OTC Bulletin ... of directors with the addition of two new members. Appointed ... Honorable William A. Chatfield. With their addition, the company board ... as the Director of the U. S. Selective Service System ...
... , CINCINNATI, Oct. 26 Harry J. Guttman, Ph.D., ... at CincyBio 2009, the Bioscience Event for Innovators and ... entrepreneurs, intellectual property lawyers, and other biotech industry service ... 7:30 AM-4:30 PM in the Kingsgate Marriott Conference Hotel ...
... one of the world,s leading research and advisory firms for ... marketed and emerging TNF-alpha inhibitors and interleukin inhibitors will drive ... 2008 to $5.2 billion in 2018 in the United States, ... , The new Pharmacor report entitled Psoriasis ...
Cached Biology Technology:Oxygen Biotherapeutics, Inc. Expands Board of Directors 2Continued Uptake of TNF-Alpha Inhibitors and Interleukin Inhibitors Will Drive $2.2 Billion Growth in the Psoriasis Drug Market 2
Several Pichia pastoris strains are available to allow you to optimize expression and recovery of your protein of interest. Table 1 provides information to help you choose the appropriate strain....
Standard 2" or 3" Plastic can be ordered with 81 or 100 cell dividers. Mini 2" Plastics Boxes come standard with 25 cell dividers. Plastic boxes can also be ordered with corresponding freezer racks...
Request Info...
5-bromouridine 5'-triphosphate (BrUTP) *10 mM in TE buffer*...
Biology Products: