Navigation Links
Thumbs up -- a tiny ancestral remnant lends developmental edge to humans
Date:9/4/2008

WALNUT CREEK, Calif. Subtle genetic changes that confer an evolutionary advantage upon a species, such as the dexterity characteristic of the human hand, while difficult to detect and even harder to reproduce in a model system, have nevertheless generated keen interest amongst evolutionary biologists. In findings published online in the September 5 edition of the journal Science, researchers from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and their collaborators, have uncovered a specifically human 13-nucelotide change concealed in the vast three-billion-letter landscape of the human genome. Their experiments reveal this stretch of DNA to be a recently evolved regulator of gee expression that, when introduced into a mouse embryo system, influence the molecular machinery to yield human limb and thumb development patterns.

The study reinforces the conclusion that certain regions of genomesthose which are conserved across many species over evolutionary time and do not encode genescan have a powerful regulatory influence on gene expression or the production of proteins.

"The study points to how human nucleotide substitutions can alter the regulation of genes in humans distinct from that of non-human primates, such as chimps," said one of the study's corresponding/senior authors Eddy Rubin, Director of Berkeley Lab's Genomics Division and the U.S. Department of Energy Joint Genome Institute. "This highlights a strategy that could be applied across the genome to understand at a molecular level what leads to differences between humans and non-human primates."

The goal of the experiment was not to produce mice with human fingers. Rather, an indirect assay was employed to test the expression readout of a single human genetic fragment and compare it with the chimp version. The strategy, which links a color-inducing reporter gene when expression is activated, turns the targeted tissue blu
'/>"/>

Contact: David Gilbert
degilbert@lbl.gov
925-296-5643
DOE/Joint Genome Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetic ancestral testing cannot deliver on its promise, study warns
2. Clues to ancestral origin of placenta emerge in Stanford study
3. Engineers create bone that blends into tendons
4. Old developmental pathways spawn revolutionary evolutionary changes
5. Researchers find association between food insecurity and developmental risk in children
6. Research pioneer in the developmental origins of psychiatric illness is awarded the Sackler prize
7. RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols
8. Pediatricians alerted to the developmental nature of underage drinking in special journal supplement
9. IVF does not increase risk of developmental disorders in children
10. Gene regulation, not just genes, is what sets humans apart
11. Humans fostering forest-destroying disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)...   Medisafe ™, the leading global medication management ... and Android smartphones and tablets, announces ... platform to allow patients to track and correlate their ... patients will be able to visualize in real-time how ... such as glucose levels and blood pressure. ...
(Date:3/24/2015)... and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has announced ... 2015-2019" report to their offering. The ... at a CAGR of 23.5 percent over the period ... and the growth prospects of the Global Iris Recognition ... size, the report considers the revenue generated from sales ...
(Date:3/23/2015)... 23, 2015   HOYOS Labs , a leading ... announced that the Company will demonstrate multiple biometrics-based technologies ... consumers at Connect:ID on March 23 through 25, 2015, ... will highlight the IEEE Biometric Open Protocol Standard; free ... enterprise access control system. BOPS was invented by HOYOS ...
Breaking Biology News(10 mins):Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... Foldit called some strategies "shocking" in how well they ... scientists., Gamers made headlines in September for unraveling the ... Today, in a paper published online at the ... University of Washington researchers reveal the creative power of ...
... Anyone reading this article is doing it right now. But ... of Virginia Tech College of Engineering researchers has published a ... that details how to learn just that, using microelectromechanical systems ... body through the air we intake. The research paper, ...
... professionals and researchers across the globe believe they are on ... lead to paralysis and death. Despite successful eradication in most ... considered endemic -- and many more in which the virus ... University,s Sackler Faculty of Medicine and the Israeli Ministry of ...
Cached Biology News:Paper uncovers power of Foldit gamers' strategies 2Paper uncovers power of Foldit gamers' strategies 3Researchers using new technology to study breath for toxins 2Researchers using new technology to study breath for toxins 3Polio still a threat to public health 2Polio still a threat to public health 3
(Date:4/21/2015)... Invetech , a global leader ... contract manufacturing, and  NanoCellect Biomedical, a company ... sorting technology for life science researchers, today announced ... platform. Headquartered in San ... microchip-based cell sorting technology. NanoCellect,s flow cytometry platform ...
(Date:4/21/2015)... 2015  scPharmaceuticals, Inc., a privately held ... subcutaneous delivery, announced today that it has ... proprietary drug product, Furosemide Injection Solution, for ... heart failure. Concurrently with its ... patch pump.  The patch pump is designed ...
(Date:4/21/2015)... 2015 Leading-edge research into ... will be presented at the 2nd International ... and clinicians from academia, industry and government ... Invibio Biomaterial Solutions. The world-leading solutions provider ... manufacturing and R&D for medical-device manufacturers, holds ...
(Date:4/20/2015)... VANCOUVER, British Columbia and ...   DelMar Pharmaceuticals, Inc. (OTCQX: DMPI) ... on developing and commercializing proven cancer therapies in ... data at the 106th Annual Meeting of ... Annual Meeting on the potential for its lead ...
Breaking Biology Technology:NanoCellect And Invetech Announce Collaboration To Develop Novel Flow Cytometry Platform For Cell Sorting And Analysis 2NanoCellect And Invetech Announce Collaboration To Develop Novel Flow Cytometry Platform For Cell Sorting And Analysis 3scPharmaceuticals Announces Start of Pivotal Trial for Novel Furosemide Solution for Subcutaneous Delivery 2scPharmaceuticals Announces Start of Pivotal Trial for Novel Furosemide Solution for Subcutaneous Delivery 32nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 22nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 3DelMar Pharmaceuticals Presents Promising Preclinical Data on VAL-083's Potential to Treat Temozolomide-Resistant Glioblastoma Multiforme (GBM) 2DelMar Pharmaceuticals Presents Promising Preclinical Data on VAL-083's Potential to Treat Temozolomide-Resistant Glioblastoma Multiforme (GBM) 3DelMar Pharmaceuticals Presents Promising Preclinical Data on VAL-083's Potential to Treat Temozolomide-Resistant Glioblastoma Multiforme (GBM) 4DelMar Pharmaceuticals Presents Promising Preclinical Data on VAL-083's Potential to Treat Temozolomide-Resistant Glioblastoma Multiforme (GBM) 5
... Biophysical Society,s 55th Annual Meeting takes place from March ... MD. There, more than 6,500 scientists will gather to ... technology at every level of biophysics -- from atoms ... The Biophysical Society is the largest association in the ...
... graphene. A two-dimensional sheet of carbon one atom thick, ... through the material with 100 times the mobility they ... challenging, say researchers at the National Institute of Standards ... graphene on a substrate transforms its bustling speedway into ...
... Jan. 20, 2011 Ardea Biosciences, Inc. (Nasdaq: ... previously announced underwritten public offering of 2,750,000 shares of ... public of $26.00 per share. The gross proceeds to ... million, before deducting the underwriting discount and other estimated ...
Cached Biology Technology:Biophysical Society to Hold 55th Annual Meeting in Baltimore, Maryland, March 5-9, 2011 2Real-world graphene devices may have a bumpy ride 2Ardea Biosciences Prices Public Offering of Common Stock 2Ardea Biosciences Prices Public Offering of Common Stock 3