Navigation Links
Three gene networks discovered in autism, may present treatment targets
Date:6/6/2014

ion networks (GFINs)groups of disrupted genes acting on biological pathways. In patients with autism, the team found three GFINs in which gene variants perturb how genes interact with proteins. Of special interest to the study group was the metabotropic glutamate receptor (mGluR) signaling pathway, defined by the GRM family of genes that affects the neurotransmitter glutamate, a major chemical messenger in the brain regulating functions such as memory, learning, cognition, attention and behavior.

Hakonarson's team and other investigators previously reported that 10 percent or more of ADHD patients have CNVs in genes along the glutamate receptor metabotropic (GRM) pathway, while other teams have implicated GRM gene defects in schizophrenia.

Based on these findings, Hakonarson is planning a clinical trial in selected ADHD patients of a drug that activates the GRM pathway. "If drugs affecting this pathway prove successful in this subset of patients with ADHD, we may then test these drugs in autism patients with similar gene variants," he said.

In ASDs and other complex neurodevelopmental disorders, common gene variants often have very small individual effects, while very rare gene variants exert stronger effects. Many of these genes with very rare defects belong to gene families that may offer druggable targets.

The three gene families found in the current study have notable functional roles. The CALM1 network includes the calmodulin family of proteins, which regulate cell signaling and neurotransmitter function. The MXD-MYC-MAX gene network is involved in cancer development, and may underlie links reported between autism and specific types of cancer. Finally, members of the GRM gene family affect nerve transmission, neuron formation, and interconnections in the brainprocesses highly relevant to ASDs.

The functional activities identified in the current study are consistent with a recent multicenter study in which Hakonarso
'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Aware Provides Biometrics Software and Services for Three Large-Scale Border Management Systems
2. Thirty teams compete to interpret three families genomes
3. Three new arthropod species have been found in the Maestrazgo Caves in Teruel
4. Research and Markets Announces the Release of Multi-Factor Authentication Market - by Model/Type [Two, Three, Four & Five-Factor], Application & Geography - Forecasts (2012 - 2017)
5. Evolution Marketing Research Grows its Practice with Addition of Three Key Industry Professionals
6. DFG to fund three new research units
7. Largest lake in Britain and Ireland has lost three-quarters of winter water birds
8. Three native aromatics indicated for use in Mediterranean extensive green roofs
9. Three UTSA College of Sciences faculty honored at AAAS Annual Meeting
10. Three new species of yellow-shouldered bats discovered in museum collections
11. Unraveling biological networks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/8/2015)... Synaptics Inc. (NASDAQ: SYNA ), the leading ... the executive management team will present at the following investor ... Telecom Conference Date: May 18, 2015 Time: 10:40am ... Cowen and Company Technology, Media & ... The New York Palace Hotel, New York, NY ...
(Date:4/27/2015)...  For more than four decades, AUVSI,s Unmanned ... premier worldwide event for the unmanned land, sea, and ... for any local, national, or trade news organization interested ... and current applications of unmanned technologies. The conference will ... billion industry, and how it will soon impact the ...
(Date:4/20/2015)... -- Huntington Memorial Hospital is the first facility in ... wireless monitoring sensor to manage heart failure (HF). The ... heart failure monitoring device that has been proven to ... manage heart failure. The CardioMEMS HF System ... artery (PA) during a non-surgical procedure to directly measure ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3
... MA] The scientific poster session, Interventions for the Treatment ... that won first prize in two American Society ... the Student Interest Group (SIG) Travel Award competition and ... Graduate Student Poster competition. The winning poster is based ...
... (Edmonton) University of Alberta led research reveals that Microraptor, a ... down and pickup fish as well as its previously known ... paleontology graduate student Scott Persons says new evidence of Microrpator,s ... very fortunate that this Microraptor was found in volcanic ash ...
... special issue of the Philosophical Transactions of The ... challenge facing our society: feeding a global population that ... consumption, while preventing widespread ecological and social impoverishment. ... The Woods Hole Research Center (WHRC) and one of ...
Cached Biology News:Penn State Hass avocado research poster wins American Society For Nutrition Annual Awards 2Ecology, economy and management of an agro-industrial Amazon frontier 2Ecology, economy and management of an agro-industrial Amazon frontier 3
(Date:5/21/2015)...  CytRx Corporation (NASDAQ: CYTR ), a ... today announced positive updated results from its ongoing ... treatment of unresectable glioblastoma multiforme (GBM), a deadly ... is designed to investigate the preliminary efficacy and ... progressed following prior treatment with surgery, radiation and ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Veolia’s ... an exclusive North American distribution agreement with VWR ... system. , With more than 160 years of ... and services for laboratory and production facilities, has ... excellence and differentiated services to enable science. ...
(Date:5/20/2015)... 2015 This year has been one ... US Patented Pearl’s Premium Ultra Low Maintenance Lawn ... country that are coming out of record bad weather. ... of major global concerns related to water, health, and ... the alternative to the standard, water-wasting, chemical-treated standard lawn. ...
(Date:5/20/2015)... 20, 2015  Health eCareers, the healthcare industry,s ... with job seekers looking for the flexibility of ... mobile and online tool dedicated exclusively to temporary ... SHIFT enables employers to quickly find and ... per diem and other temporary positions, eliminating the ...
Breaking Biology Technology:CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Breakthrough 4th Generation Low Maintenance Lawn Seed Offers Solution to California Drought 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 3
... This is part II of a two-part column on ... focused on the recent controversy over Avandia, GlaxoSmithKline's diabetes drug. ... be so deeply integral to the system that it might be ... For much of its history, the Food and Drug Administration's ...
... Department of Energy will invest up to $375 million ... $125 million for a center led by the University ... , ,The Madison bioenergy research facility , which will ... operate in collaboration with Michigan State University and ...
... Madison, Wis. - The total cost of ownership ... a software implementation, but it might just be the ... turf. , ,The ability to establish and continually re-evaluate ... the business, might be the difference between success and ...
Cached Biology Technology:Reforming FDA: Focus on safety, let market judge efficacy 2Reforming FDA: Focus on safety, let market judge efficacy 3Reforming FDA: Focus on safety, let market judge efficacy 4Reforming FDA: Focus on safety, let market judge efficacy 5Reforming FDA: Focus on safety, let market judge efficacy 6UW-Madison to receive $125M for bioenergy research center 2UW-Madison to receive $125M for bioenergy research center 3CIOs focus on the business case while facing 'authority erosion' 2CIOs focus on the business case while facing 'authority erosion' 3
... Zyagen tissue microarrays are derived from Paraffin ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... on coated slides. Sections are large (3-5 ...
... microarrays are derived from frozen embedded tissue ... control procedures to ensure the highest quality. ... in one block, sectioned at a thickness ... Sections are large (3-5mm in diameter) in ...
... The MyiQ detection system is used ... I, FAM, VIC, TET, or JOE fluorophores ... simultaneous collection of fluorescence data from 96 ... quantitation, and customizable end-point analysis. The system ...
... Chromo4 real-time PCR detector is an optical ... a DNA Engine or Dyad Disciple gradient-capable ... a compact scanning photonics shuttle that contains ... 500-535 nm, 555-585 nm, 620-650 nm) and ...
Biology Products: