Navigation Links
Three gene networks discovered in autism, may present treatment targets
Date:6/6/2014

A large new analysis of DNA from thousands of patients has uncovered several underlying gene networks with potentially important roles in autism. These networks may offer attractive targets for developing new autism drugs or repurposing existing drugs that act on components of the networks.

Furthermore, one of the autism-related gene pathways also affects some patients with attention-deficit hyperactivity disorder (ADHD) and schizophreniaraising the possibility that a class of drugs may treat particular subsets of all three neurological disorders.

"Neurodevelopmental disorders are extremely heterogeneous, both clinically and genetically," said study leader Hakon Hakonarson, M.D., Ph.D., director of the Center for Applied Genomics at The Children's Hospital of Philadelphia (CHOP). "However, the common biological patterns we are finding across disease categories strongly imply that focusing on underlying molecular defects may bring us closer to devising therapies."

The study by Hakonarson and colleagues, appearing online today in Nature Communications, draws on gene data from CHOP's genome center as well as from the Autism Genome Project and the AGRE Consortium, both part of the organization Autism Speaks.

Autism spectrum disorders (ASDs), of which autism is the best known, are a large group of heritable childhood neuropsychiatric conditions characterized by impaired social interaction and communication, as well as by restricted behaviors. The authors note that recent investigations suggest that up to 400 distinct ASDs exist.

The current research is a genome-wide association study comparing more than 6,700 patients with ASDs to over 12,500 control subjects. It was one of the largest-ever studies of copy number variations (CNVs) in autism. CNVs are deletions or duplications of DNA sequences, as distinct from single-base changes in DNA.

The study team focused on CNVs within defective gene family interact
'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Aware Provides Biometrics Software and Services for Three Large-Scale Border Management Systems
2. Thirty teams compete to interpret three families genomes
3. Three new arthropod species have been found in the Maestrazgo Caves in Teruel
4. Research and Markets Announces the Release of Multi-Factor Authentication Market - by Model/Type [Two, Three, Four & Five-Factor], Application & Geography - Forecasts (2012 - 2017)
5. Evolution Marketing Research Grows its Practice with Addition of Three Key Industry Professionals
6. DFG to fund three new research units
7. Largest lake in Britain and Ireland has lost three-quarters of winter water birds
8. Three native aromatics indicated for use in Mediterranean extensive green roofs
9. Three UTSA College of Sciences faculty honored at AAAS Annual Meeting
10. Three new species of yellow-shouldered bats discovered in museum collections
11. Unraveling biological networks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... tube connectors, designed by an international standards process, will ... According to an invited review published in the OnlineFirst ... NCP ), the official journal of the American Society ... will greatly reduce the occurrence of misconnection that can ... connectors, which are used to join medical devices, components, ...
(Date:8/21/2014)... from North Carolina State University have developed a novel ... model has applications for creating new materials as well ... "Our new technique allows us to model much larger ... much more quickly," says Nan Li, lead author of ... in NC State,s Department of Materials Science and Engineering. ...
(Date:8/20/2014)... a study of 158 pregnant teenagers in Rochester, NY, ... intentional consumption of ice, cornstarch, vacuum dust, baby powder ... Cornell study. , Moreover, such teens had significantly lower ... eat nonfood substances. , Pregnant teens, regardless of pica, ... lead to iron deficiency and anemia. Low iron in ...
Breaking Biology News(10 mins):New feeding tube connectors will improve patient safety 2Researchers develop models to study polyelectrolytes, including DNA and RNA 2Pica in pregnant teens linked to low iron 2
... WASHINGTON, D.C. (March 7, 2011) -- All our daily activities, ... on signals carried along the body,s vast network of neurons. ... small molecules within nerve cells -- receptors, ion channels, and ... recently, the study of these molecules in real time has ...
... gene that causes Hajdu-Cheney syndrome, a disorder of the ... The study, published in Nature Genetics today, ... highlights the gene as a potential target for treating ... reported cases of Hajdu-Cheney syndrome (HCS), of which severe ...
... separates from Greenland, is the calving due to typical ... called the Scalable, Efficient, and Accurate Community Ice Sheet ... Ridge National Laboratory, aims to use state-of-the-art simulation to ... climate. ORNL computational Earth scientist Kate Evans leads ...
Cached Biology News:Gene responsible for severe osteoporosis disorder discovered 2
(Date:8/20/2014)... 20, 2014 The 6th Annual ... held on October 29-30 in San Francisco, CA. This ... and government researchers and clinicians focused on addressing and ... , In the twelve years since the sequencing of ... been introduced with pharmacogenetic information in the label and ...
(Date:8/20/2014)... SAN JOSE, Calif. , Aug. 20, 2014 ... UCSD highlights the transformative collaboration between the school,s ... (IoT).  As part of the Intel® Software Academic ... between computer sciences and the human body.  ... The study exhibits the work of ...
(Date:8/20/2014)... Cranford, NJ (PRWEB) August 20, 2014 ... solutions, announced today that it has expanded its myPROpad™ ... of the EQ-5D-5L, one of the most widely ... for measuring general health status. The EQ-5D is used ... to generate a measure that can be used to ...
(Date:8/19/2014)... (PRWEB) August 20, 2014 One ... regenerative medicine is an inadequate vascular supply. Nutrient ... and decellularized tissues is critical for successful regeneration ... attempted to mitigate deficiencies in vascularization and promote ... scaffold bioactivity, optimizing scaffold design and architecture, and ...
Breaking Biology Technology:6th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2EQ-5D™ Assessment Now Available for iPad 2Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2
... LA JOLLA, Calif., Jan. 13 Burnham ... an assay development and license agreement with ... L.L.C. (J&JPRD). The agreement is Burnham,s ... company.Under this multi-year agreement, Burnham will provide ...
... - GeneNews Limited (TSX: GEN), a company focused ... detection of diseases and personalized health management, today ... 7,473,528 entitled "Method for the detection of Chagas ... protects the Company,s discovery of a blood biomarker-based ...
... Datafarm, Inc. a leading provider of Electronic Document Publishing Solutions and ... announce the appointment of Mr. Daniel F. Orfe to Vice President, ... will oversee Datafarm,s Regulatory Services Group. , ... Marlborough, ...
Cached Biology Technology:Burnham Announces Assay Development and License Agreement with Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 2GeneNews granted U.S. patent for Chagas disease based on Sentinel Principle(TM) platform 2Datafarm, Inc., Announces the Appointment of Daniel F. Orfe to Vice President, Global Regulatory Submission Services 2Datafarm, Inc., Announces the Appointment of Daniel F. Orfe to Vice President, Global Regulatory Submission Services 3Datafarm, Inc., Announces the Appointment of Daniel F. Orfe to Vice President, Global Regulatory Submission Services 4
... of Tracker, plus software to note when the ... a food reward.The Spatial Behavior line is a ... camera, frame grabber, and feature extraction software and ... up to 6 moving animals. Software automatically ...
... Behavior System. Enables replay of a reorded ... parts, and scoring events and duration by button ... Behavior line is a family of instruments all ... feature extraction software and that can track two ...
... fermentation systems for cultivation of microorganisms and ... of bio-pharmaceutical products maximum performance and economy ... and cell fermentation 10 L 1,500 ... ,*Fully automated control system ,*High-quality ...
... technology, SilenceMag is the most efficient ... and easy to use, SilenceMag is ... designed for siRNA delivery, SilenceMag allows ... doses of siRNA.,SilenceMag formulation gives reliable ...
Biology Products: