Navigation Links
Three gene networks discovered in autism, may present treatment targets
Date:6/6/2014

A large new analysis of DNA from thousands of patients has uncovered several underlying gene networks with potentially important roles in autism. These networks may offer attractive targets for developing new autism drugs or repurposing existing drugs that act on components of the networks.

Furthermore, one of the autism-related gene pathways also affects some patients with attention-deficit hyperactivity disorder (ADHD) and schizophreniaraising the possibility that a class of drugs may treat particular subsets of all three neurological disorders.

"Neurodevelopmental disorders are extremely heterogeneous, both clinically and genetically," said study leader Hakon Hakonarson, M.D., Ph.D., director of the Center for Applied Genomics at The Children's Hospital of Philadelphia (CHOP). "However, the common biological patterns we are finding across disease categories strongly imply that focusing on underlying molecular defects may bring us closer to devising therapies."

The study by Hakonarson and colleagues, appearing online today in Nature Communications, draws on gene data from CHOP's genome center as well as from the Autism Genome Project and the AGRE Consortium, both part of the organization Autism Speaks.

Autism spectrum disorders (ASDs), of which autism is the best known, are a large group of heritable childhood neuropsychiatric conditions characterized by impaired social interaction and communication, as well as by restricted behaviors. The authors note that recent investigations suggest that up to 400 distinct ASDs exist.

The current research is a genome-wide association study comparing more than 6,700 patients with ASDs to over 12,500 control subjects. It was one of the largest-ever studies of copy number variations (CNVs) in autism. CNVs are deletions or duplications of DNA sequences, as distinct from single-base changes in DNA.

The study team focused on CNVs within defective gene family interact
'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Aware Provides Biometrics Software and Services for Three Large-Scale Border Management Systems
2. Thirty teams compete to interpret three families genomes
3. Three new arthropod species have been found in the Maestrazgo Caves in Teruel
4. Research and Markets Announces the Release of Multi-Factor Authentication Market - by Model/Type [Two, Three, Four & Five-Factor], Application & Geography - Forecasts (2012 - 2017)
5. Evolution Marketing Research Grows its Practice with Addition of Three Key Industry Professionals
6. DFG to fund three new research units
7. Largest lake in Britain and Ireland has lost three-quarters of winter water birds
8. Three native aromatics indicated for use in Mediterranean extensive green roofs
9. Three UTSA College of Sciences faculty honored at AAAS Annual Meeting
10. Three new species of yellow-shouldered bats discovered in museum collections
11. Unraveling biological networks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces that its ... New York Design Awards under the category  ,Product Design ... Design Awards are part of a global multi-disciplinary awards ... from the marketplace, industry and judging panel. Winners will ...
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) has ... - NEC" report to their offering. ... to supply a range of IT security management and ... on the development of a Big Data and cloud ... Asia-Pacific region is a core ...
(Date:4/6/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... focused on the growing mobile commerce market, announced ... for MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND SYSTEM ... NXT-ID introduces a new revolutionary method and system ... use of miniature antenna modules for multiple purposes ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3NEC Security Competitive Profile 2015 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4
... Research at the University of Liverpool has found that Shakespearean ... bard's plays and poetry. , Shakespeare uses a linguistic technique ... noun to serve as a verb. Researchers found that ... means before it understands the function of the word within ...
... of children is effectively an estimate of the probability ... a new study recently published in Journal of Vision, ... Research in Vision and Ophthalmology (ARVO). , Participants ... half of which portrayed actual siblings. In one ...
... in the world. Half the country is arid or ... are scarce. Yet 1.3 billion people live in China, ... At the same time, China's environmental problems of energy and ... are escalating. , The September issue of Frontiers ...
Cached Biology News:Reading Shakespeare has dramatic effect on human brain 2China's environmental challenges 2
(Date:4/17/2015)... CIO Review ( http://www.cioreview.com ) has ... Promising Pharma and Life Science Technology Solution Providers 2015. ... software platform for life sciences companies. , The ... of experts and members of CIO Review’s editorial board ... has been on our radar for some time now ...
(Date:4/17/2015)... April 17, 2015 LC Sciences ... technologies, announced today that it is seeking beta ... innovative multiplex PCR based targeted sequencing technology. The ... analysis, that enables accurate detection of rare variants. ... Omega-Primer™ technologies. The company will collaborate with beta ...
(Date:4/16/2015)... (PRWEB) April 16, 2015 Cytokinetics, Incorporated ... report first quarter results on Thursday, April 30, 2015 ... senior management will host a conference call at 4:30 ... and the company’s outlook for the future. , The ... accessed from the homepage and in the Investor Relations ...
(Date:4/16/2015)... According to the 2014 Liberty ... source was ranked first among the leading causes ... lifting, pushing, pulling, holding, carrying, or throwing and ... David Round Company takes statistics like this very ... to develop and design equipment that prevents these ...
Breaking Biology Technology:MMIS Chosen by CIO Review as Top 20 Most Promising Pharma and Life Science Technology Solution Providers 2015 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2
... BEIJING , Feb. 8 /PRNewswire-Asia-FirstCall/ -- China Medical Technologies,Inc. (the "Company") (Nasdaq: CMED ), a ... in March 2010 : , , Investor Conference ... Location, Rodman & Renshaw Annual March 7-9, 2010 ... ...
... , , NEW YORK , ... firm specializing in investor relations and corporate communications for domestic ... and Matthew Haines have joined as Managing Directors. ... corporate experience that will serve our clients well,” said ...
... , , , , ... -- 3SBio Inc. (Nasdaq:, SSRX ) ("3SBio" or "the ... researching, developing, manufacturing and marketing,biopharmaceutical products, today announced a ... and commercialize its,Nephoxil(R) pharmaceutical product for the treatment of ...
Cached Biology Technology:China Medical Technologies to Participate Investor Conferences in March 2010 2MBS Value Partners Hires Two New Senior Staff Members 23SBio and Panacor Bioscience Enter Collaboration and License Agreement to Develop and Commercialize Nephoxil(R) for Hyperphosphatemia 23SBio and Panacor Bioscience Enter Collaboration and License Agreement to Develop and Commercialize Nephoxil(R) for Hyperphosphatemia 33SBio and Panacor Bioscience Enter Collaboration and License Agreement to Develop and Commercialize Nephoxil(R) for Hyperphosphatemia 4
... Molecular Probes is pleased to ... for the ultrasensitive detection of primary ... at Indiana University, the ATTO-TAG reagents ... o-phthaldialdehyde (OPA), naphthalene-2,3-dicarboxaldehyde (NDA) and anthracene-2,3-dicarboxaldehyde, ...
... Molecular Probes is pleased to offer ... the ultrasensitive detection of primary amines. ... Indiana University, the ATTO-TAG reagents are ... (OPA), naphthalene-2,3-dicarboxaldehyde (NDA) and anthracene-2,3-dicarboxaldehyde, all ...
...
Microlite 1+ 1x12 Strip assembled, flat bottom; the ideal vessel for low signal luminescent reactions, offering medium binding with enhanced dynamic range, extra high reflectivity and minimal cross t...
Biology Products: