Navigation Links
This is your brain on Cryptococcus: Pathogenic fungus loves your brain sugar
Date:4/5/2010

DURHAM, N.C. -- Highly dangerous Cryptococcus fungi love sugar and will consume it anywhere because it helps them reproduce. In particular, they thrive on a sugar called inositol which is abundant in the human brain and spinal cord.

To borrow inositol from a person's brain, the fungi have an expanded set of genes that encode for sugar transporter molecules. While a typical fungus has just two such genes, Cryptococcus have almost a dozen, according to Joseph Heitman, M.D., Ph.D., chairman of the Duke Department of Molecular Genetics and Microbiology.

"Inositol is abundant in the human brain and in the fluid that bathes it (cerebral spinal fluid), which may be why this fungus has a predilection to infect the brain and cause meningitis," Heitman said. "It has the machinery to efficiently move sugar molecules inside of its cells and thrive."

The findings on Cryptococcus genes were published online this week in the inaugural issue of mBio, a new open access microbiology journal.

This specialized brain attack likely occurred because these fungi adapted to grow on plants in the wild, which also are abundant in inositol, said lead author Chaoyang Xue, Ph.D., formerly a postdoctoral research associate in the Heitman lab and now an assistant professor at the Public Health Research Institute at the University of Medicine and Dentistry of New Jersey (UMDNJ). "In fact, this pathogenic yeast has more inositol transporters than all other fungi we have compared it to in the fungal kingdom, based on what we know from genome research."

The team of researchers discovered that inositol stimulates Cryptococcus to sexually reproduce. "A connection between the high concentration of free inositol and fungal infection in the human brain is suggested by our studies," Xue said. "Establishing such a connection could open up a new way to control this deadly fungus."

Cryptococcus' love for sugar may also be a fungal Achilles Heel, Heitman said. "Now scientists may be able to target the fungi by developing ways to put them on the fungal equivalent of an Atkin's low-carbohydrate diet so they will stop multiplying." He said researchers could use the new findings to devise different types of strategies to block Cryptococcus infections.

These studies will be reported in the inaugural issue mBio, which will be launched in May by the American Society of Microbiology as an online journal that spans all areas of microbiology.


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Related biology news :

1. Invasion of the brain tumors
2. HIV is a double hit to the brain
3. AIDS interferes with stem cells in the brain
4. 60 second test could help early diagnosis of common brain diseases
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
8. Inside the brain of a crayfish
9. Specific brain protein required for nerve cell connections to form and function
10. Brains timing linked with timescales of the natural visual world
11. Adult brain can change, study confirms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
(Date:4/14/2016)... TEL AVIV, Israel , April 14, 2016 /PRNewswire/ ... in Behavioral Authentication and Malware Detection, today announced the ... has already assumed the new role. Goldwerger,s ... for BioCatch, on the heels of the deployment of ... In addition, BioCatch,s behavioral biometric technology, which discerns unique ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys has ... CEO, Barrett Bready , M.D., who returned to ... the original technical leadership team, including Chief Technology Officer, ... Product Development, Steve Nurnberg and Vice President of Software ... the company. Dr. Bready served as CEO ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... 2016 Despite the volatility that continues ... space. Today,s pre-market research on ActiveWallSt.com directs the investor community,s ... RDUS ), Cerus Corp. (NASDAQ: CERS ... Five Prime Therapeutics Inc. (NASDAQ: FPRX ). Register ... http://www.activewallst.com/ On Wednesday, shares in ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... FireflySci cuvettes are used in leading laboratories all over the globe. Their cute ... In addition to manufacturing awesome cuvettes, FireflySci makes spectrophotometer calibration standards that never ...
(Date:5/25/2016)... ... May 25, 2016 , ... The Ankle Plating ... options designed to address fractures of the distal tibia and fibula. This system ... Ankle Plating System 3 is composed of seven plate families that span the ...
(Date:5/25/2016)... ... ... Scientists at the University of Athens say they have evidence that the variety ... that could lead to one good one. Surviving Mesothelioma has just posted an article ... team evaluated 98 mesothelioma patients who got a second kind of drug ...
Breaking Biology Technology: