Navigation Links
Third-party blood stem cell transplantation as a factor to impact on poor graft function
Date:3/18/2013

Putnam Valley, NY. (March 18, 2013) When a research team in China evaluated the efficacy and safety of using mesenchymal stem cells (MSCs) expanded from the bone marrow of non-self-donors to treat patients experiencing poor graft function (PGF) after receiving transplants of non-self-donated blood stem cells (allo-HSCT), they found that the mesenchymal stem cells were both safe and effective for treating primary and secondary PGF.

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0832liu.

"Allogenic hematopoietic stem cell transplantation can cure many hematologic diseases," said study co-author Dr. Qifa Liu of the Southern Medical University in Guangzhou, China. "However, poor graft function is a complication that occurs in five to 27 percent of patients receiving allo-HSCT and is associated with considerable morbidity and mortality."

According to the researchers, graft function may be poor after allogenic hematopoietic stem cell transplantation because of slow or incomplete reconstitution of blood counts or decreasing blood counts. PGF, which is poorly understood, is a potentially life-threating condition when it leads to graft vs. host disease (GVHD).

In this study, when 20 patients demonstrated risk factors for PGF, researchers infused them with MSCs derived from bone marrow from third-party donors. PGF had developed in five patients with acute GVHD and two patients had chronic GVHD.

"The patients receiving the MSCs achieved either complete responses or improved GVHD," said the researchers. "However, the PGF did not improve when immunosuppressive agents were given. This means that additional studies will be needed to determine whether PGF is associated with immunologic factors."

One unanswered question, said the researchers, was whether the immunosuppressive properties of MSCs are an important factor that could have a favorable impact on potential problems such as an increased risk of infection or tumor relapse following cell transplantation.

"Although six of 20 patients died from infections within the first 100 days of MSC transplantation, we could not safely conclude that MSCs increased the incidence of infections other than Epstein-Barr," they wrote.

In conclusion, the researchers noted that "clinical applications of human MSCs are evolving rapidly with goals of improving hematopoietic engraftment and preventing GVHD after allogenic hematopoietic stem cell transplantation."

"This study highlights the potential impact of allogeneic mesenchymal stem cell transplants as an adjunctive therapy for hematopoietic stem cell transplantation to reduce the likelihood of the patient developing graft versus host disease after exhibiting risk factors for poor functioning of the grafted cells" said Dr. Paul R. Sanberg, distinguished professor at the Center of Excellence for Aging and Brain Repair, University of South Florida.
'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. White blood cells found to play key role in controlling red blood cell levels
2. Prenatal exposure to pesticide DDT linked to adult high blood pressure
3. Temp-controlled nanopores may allow detailed blood analysis
4. Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model
5. Stressed proteins can cause blood clots for hours
6. Study uncovers enzymes double life, critical role in cancer blood supply
7. Manchester patients take part in pioneering heart attack blood test trial
8. Blood vessels sniff gut microbes to regulate blood pressure
9. Childhood blood lead levels rise and fall with exposure to airborne dust in urban areas
10. Blood is thicker than water -- and blood plasma is, too
11. Rice University lab show how blood vessels regroup after stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... PARIS , June 15, 2017  IBM (NYSE: IBM ... the international tech event dedicated to developing collaboration between startups ... on June 15-17. During the event, nine startups will ... deliver value in various industries. ... in the international market, with a 30 percent increase in ...
(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ( ... online age and identity verification solutions, announced today they ... Conference 2017, May 15 thru May 17, 2017, in ... and International Trade Center. Identity impacts ... and in today,s quickly evolving digital world, defining identity ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... Ringle, WI (PRWEB) , ... ... ... MedJobCafe.com announce the launch of a redesigned, easier-to-navigate website for all six ... job boards for physicians, nurses, dentists, pharmacists, physical and occupational therapists, and ...
(Date:6/23/2017)... ... 2017 , ... The Academy of Model Aeronautics (AMA), the ... (UAA), the unifying voice for collegiate aviation education, are launching a joint UAS ... success through a STEM-based education platform. , Much like the program currently available ...
(Date:6/22/2017)... ... June 21, 2017 , ... Beaker, the industry’s ... in the life sciences industry, today announces a strategic partnership with Alcami Corporation, ... full advantage of Beaker’s expertise in executive recruitment solutions, providing Alcami with access ...
(Date:6/22/2017)... ... June 21, 2017 , ... RMC Pharmaceutical Solutions, Inc. announces ... Reinhardt to manage the new site. , Tim has 25 years of pharmaceutical ... recent role as the Director of Manufacturing and Supplier Quality Assessment. This ...
Breaking Biology Technology: