Navigation Links
Third generation map of human genetic variation published
Date:9/1/2010

ociated with complex human diseases, such as cardiovascular disease, diabetes, cancer and many other health conditions.

The first- and second-generation versions of HapMap resulted from the analysis of DNA collected from 270 volunteers from four geographically diverse populations: Yoruba in Ibadan, Nigeria; Japanese in Tokyo; Han Chinese in Beijing; and Utah residents with ancestry from northern and western Europe.

The third-generation HapMap, reported in the Sept. 2 issue of the journal Nature, is the largest survey of human genetic variation performed thus far. It has data on 1,184 people, including the initial HapMap samples. Additional human samples were collected from the original populations and from seven new populations: individuals of African ancestry from the Southwestern United States; Chinese individuals from metropolitan Denver; Gujarati Indians from Houston; Luhya people from Webuye, Kenya; Maasai people from Kinyawa, Kenya; individuals of Mexican ancestry from Los Angeles; and individuals from Tuscany, Italy. No medical or personal identifying information was obtained from the HapMap donors. However, the samples are identified by the population from which they were collected.

Researchers analyzed approximately 1.6 million SNPs in about 500 samples from the four original populations and more than 650 samples from the seven new populations. In addition, the consortium sequenced 10 regions totaling about 1 million base pairs in 692 samples from this set in 10 of the 11 populations. More than 800 copy-number variants, where people have different numbers of copies of genomic regions, were also added to the resource.

As expected, the increased number of samples allows detection of variants that are much rarer than could be found by the earlier HapMaps. Because of human population history, lower-frequency variation is shared less among populations. For instance, 77 percent of the detected SNPs were new, rev
'/>"/>

Contact: Geoff Spencer
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. BIO-key(R) Announces Additional $245,000 in Third Quarter Public Safety Orders
2. Communication Intelligence Corporation Reports Third Quarter 2008 Financial Results
3. Orchid Cellmark Reports Third Quarter 2008 Financial Results
4. Results of the third school nutrition dietary assessment study published
5. CWRU receives $5 million from Ohio Third Frontier Commission
6. Discovery to aid in future treatments of third-world parasites
7. Quest Diagnostics Reports Strong Performance in Third Quarter 2009
8. Aware, Inc. Reports Third Quarter 2009 Financial Results
9. Aware, Inc. Reports Third Quarter 2009 Financial Results
10. Quest Diagnostics Reports Strong Performance in Third Quarter 2009
11. SCM Microsystems Reports Third Quarter 2009 Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... Like discriminating thieves, prostate cancer tumors scavenge and hoard ... But such avarice may be a fatal weakness. ... to kill prostate cancer cells by delivering a trove ... the diseased cells brimming with the mineral, leaving non-cancer ... drugs already commercially available for other uses, could soon ...
(Date:10/14/2014)... Mount Sinai-led research team has discovered a new kind of ... a cell that lines liver blood vessels, according to a ... . The existence of such a cell type contradicts current ... embryo, and may hold clues to origins of, and future ... from a single cell into a complex being made up ...
(Date:10/14/2014)... cancer likely takes between 10 and 20 years ... "broad window" of intervention if detected early, which ... predisposition, say Australian clinical researchers. , Dr ... Garvan Institute of Medical Research, analysed medical histories ... 766 pancreatic cancer patients, operated on between 1994 ...
Breaking Biology News(10 mins):Prostate cancer's penchant for copper may be a fatal flaw 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 3Early detection window when pancreatic cancer is in the family 2
... Mellon University President Subra Suresh has been elected a ... the only current university president to be elected to ... is among the highest professional distinctions accorded to engineers, ... those who have made outstanding contributions to their fields. ...
... Medicine of the National Academies honored members Donald Berwick, R. ... today at the IOM,s 43rd annual meeting. ... member for distinguished service over an extended period. He ... Care in America, which produced the landmark reports To Err ...
... The Yangtze finless porpoise, which inhabits the high-traffic waters ... endangered, with only about 1,000 animals alive today. Scientists ... colleagues are using medical technology to shed new light ... waterway punctuated by constant shipping, dredging, and underwater construction. ...
Cached Biology News:Carnegie Mellon President Subra Suresh elected to Institute of Medicine 2Institute of Medicine honors members for outstanding service 2Institute of Medicine honors members for outstanding service 3Seeing in the dark 2Seeing in the dark 3
(Date:10/18/2014)... The Asia-Pacific Bio-based Advanced Phase Change Materials Market ... change material market in Asia-Pacific with analysis and ... of the Asia-Pacific Bio-based Advanced Phase Change Materials ... in-depth analysis provided. This also provides a glimpse ... phase change material market, and is supported by ...
(Date:10/18/2014)... The Asia-Pacific Liquid Crystal on Silicon (LCoS) ... in Asia-Pacific with analysis and forecast of revenue. This ... is expected to reach $380.0 million by 2018, at ... Browse through the TOC of the Asia-Pacific LCoS display ... analysis provided. This also provides a glimpse of the ...
(Date:10/18/2014)... The report " Cloud Analytics Market ... Speech; Machine; Video; Predictive Analytics: Global Advancements, Delivery ... Analysis (2013 - 2018) ", defines and segments ... segments with an in-depth analysis and forecasting of ... driving this market, various restraints, and opportunities impacting ...
(Date:10/17/2014)... SAN DIEGO and HILDEN, ...   , Translational research ... new capabilities being presented at the American Society ... Volume of 250,000-plus DNA samples linked to Ingenuity ... superior depth for genomic analysis  Ingenuity ...
Breaking Biology Technology:The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 4The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 3QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 4QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 5QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 6
... University of Oklahoma professor has been selected as a 2010 ... contributions in chemistry in either academia, government or industry. ... Biochemistry, will be honored during a special ceremony at the ... 2010 Class of Fellows is only the second group of ...
... An international team of scientists and industrialists is to meet ... new technique for harnessing green energy. Norwegian company EnSol ... cell technology which they seek to develop commercially by 2016. ... University of Leicester Department of Physics and Astronomy to develop ...
... de-radicalize terrorists show promise, if well-run, says a new ... findings the most comprehensive to date, based on ... conference this week. Prisons and Terrorism: Radicalization ... the National Consortium for the Study of Terrorism and ...
Cached Biology Technology:New technique announced to turn windows into power generators 2Terrorist de-radicalization shows promise, comprehensive study finds 2
... Tracker Intracellular Localization Kit with TransIT-siQUEST ... approach to directly label and deliver ... efficient yet non-destructive manner, for in ... functional inhibition of target gene expression ...
... mir Vana miRNA Bioarray Essentials Kit provides ... and post-hybridization washing of the mir Vana ... has been labeled using Ambions mir Vana ... positive control miRNA (Bioarray ID BA10001) that should ...
... The Label IT siRNA Tracker Intracellular ... to directly label and deliver siRNA, of ... manner, for in vitro tracking experiments. Subcellular ... expression can be monitored following introduction of ...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z71,344-9) ... assistance. ID clarifier: box holds ...
Biology Products: