Navigation Links
Therapy slows onset and progression of Lou Gehrig's disease, study finds
Date:9/9/2013

earlier and advances more quickly. In the other, the disease develops later and progresses more slowly. All of the mice received a single injection of AAV9-SOD1-shRNA before or after disease onset.

Results showed that in the rapid-disease-progressing model, mice treated before disease onset saw a 39 percent increase in survival compared to control treated mice. Strikingly, in mice treated at 21 days of age, disease progression was slowed by 66 percent. Perhaps more surprising was the finding that even after symptoms surfaced in these models, treatment still resulted in a 23 percent increase in survival and a 36 percent reduction in disease progression. In the slower-disease-onset model, treatment extended survival by 22 percent and delayed disease progression by 38 percent.

"The extension of survival is fantastic, and the fact that we delayed disease progression in both models when treated at disease onset is what drives our excitement to advance this work to human clinical trials," said Kevin Foust, PhD, co-first author on the manuscript and an assistant professor in neurosciences at The Ohio State University College of Medicine.

In addition to the potential therapeutic benefit, the study also offers some interesting insights into the biological underpinnings of ALS. The role of motor neurons in ALS has been well documented, but this study also highlighted another key playerastrocytes, the most abundant cell type in the human brain and supporters of neuronal function.

"Recent work from our collaborator Dr. Cleveland has demonstrated that astrocytes and other types of glia are as important if not more important in ALS, as they really drive disease progression," said Dr. Kaspar. "Indeed, in looking at data from mice, more than 50 percent of astrocytes were targeted throughout the spinal cord by this gene-delivery approach."

Ideally, a therapy would hit motor neurons and astrocytes equally hard. The best way to do th
'/>"/>

Contact: Gina Bericchia
Gina.Bericchia@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Physiotherapy in Singapore Clinic Urbanrehab Pte Ltd Announces the Opening of an Additional Location
2. Chemotherapy before radiotherapy for testicular cancer could reduce long-term side-effects
3. ITN type 1 diabetes study identifies subset of patients with strong response to therapy
4. Combined therapy could repair and prevent damage in Duchenne muscular dystrophy
5. Study suggests way to fight therapy resistant leukemia by blocking DNA repair
6. An effective initial polytherapy for infantile spasms
7. UCLA stem cell gene therapy for sickle cell disease advances toward clinical trials
8. Neuroblastoma: Autophagy protects from chemotherapy
9. Dendritic cell therapy improves kidney transplant survival, Pitt team says
10. No danger of cancer through gene therapy virus
11. An article in Cell reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... SAN JOSE, Calif. , Aug. 6, 2015 ... the leading developer of human interface solutions, today ... and TouchPad technologies on Windows 10. Microsoft leveraged ... fundamental to the operating system. ... and drivers are fully certified with Microsoft,s Precision ...
(Date:8/4/2015)... ) today reported financial and operating results for the second quarter ... quarter contract revenue of $ 85.2 million, a ... of 26 % , Second quarter adjusted ... royalties in the current quarter , Operating cash ... to present another strong financial quarter, with all our divisions achieving ...
(Date:7/31/2015)... 2015 La 10e Conférence internationale sur ... par le BGI du 22 au 25 octobre ... Chine. La conférence célèbre son 10e ... l,ICG est devenue l,une des réunions annuelles mondiales ... et c,est aussi la plus dynamique, la plus ...
Breaking Biology News(10 mins):Synaptics Chosen for Human Interface Co-Development on Windows 10 2AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3
... Voter Rolls and ... National ID Cards, ... Bulletin Board: BKYI), a leader in,finger-based biometric identification and wireless public ... prepackaged and customized software,solutions, today announced that they have been awarded ...
... the topping-out ceremony for the experimental hall of PETRA III ... Hamburg. On occasion of the structural completion of the building, ... Ole von Beust visited the Helmholtz research centre DESY. Its ... in 2009. PETRA III is a milestone on the ...
... A pasture improvement research program by Dr. Dariusz Malinowski ... an alternative to winter wheat pastures. But these ... parts of the nation, said Malinowski, a Texas Agricultural ... the Mediterranean Basin of southern Europe and northern Africa. ...
Cached Biology News:BIO-key(R) and Tiger IT Awarded a Follow-on Contract for Nationwide Voter / Citizen Registration in Bangladesh 2BIO-key(R) and Tiger IT Awarded a Follow-on Contract for Nationwide Voter / Citizen Registration in Bangladesh 3BIO-key(R) and Tiger IT Awarded a Follow-on Contract for Nationwide Voter / Citizen Registration in Bangladesh 4Brilliant perspectives 2Brilliant perspectives 3Summer-dormant tall fescue grass shows promise for pasture improvements 2Summer-dormant tall fescue grass shows promise for pasture improvements 3
(Date:8/31/2015)... Aug. 31, 2015 Research and Markets ( ... "Middle East & Africa Biomedical Sensors Market - Growth, ... The Middle East ... $0.84 billion by 2018 at a CAGR of 3.26% ... will bring Biomedical sensors that are adaptable to the ...
(Date:8/31/2015)... Mass. , Aug. 31, 2015  RXi ... company focused on discovering and developing innovative therapies ... today announced that the 30-day review period following ... (IND) for ocular indications with the U.S. Food ... IND is now active. Logo ...
(Date:8/31/2015)... Calif. , Aug. 31, 2015 FLX ... and development of novel cancer immunotherapies, announced today that ... as Chief Executive Officer and William Ho , ... Ho join an experienced management team led by veterans ... Fridman , Ph.D., Chief Scientific Officer; Jay Powers ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... priority in the drug development approval process. Thus, innovator companies must understand what ... Technologies, Inc., a Chicago-based CMO, has been hosting multiple educational panels and seminars ...
Breaking Biology Technology:Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 3RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 4FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 3FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 4Regis Shares Expert Advice on Impurities in Drug Development 2Regis Shares Expert Advice on Impurities in Drug Development 3
... PITTSBURGH, Feb. 2, 2011 Forensic DNA profiling has ... people in the aftermath of mass violence and disaster, ... to identify and analyze the major ethical and policy ... (Logo: http://photos.prnewswire.com/prnh/20020422/CMULOGO) The National ...
... 2, 2011 New England Biolabs has expanded its ... generation sequencing to include NEBNext® Small RNA Sample Prep ... NEBNext Small RNA Sample Prep Set 3 for sequencing ... new and unique protocol, which results in higher yields ...
... N.M., Feb. 2, 2011 Elixir Bio-Tech Inc. (EBT), ... one of the top fifty winners of the FundingPost,s ... EBT is launching its Algae Biomass Feedstock project in ... multi-purpose feedstock with ground-breaking Proprietary and Patent Pending Technology ...
Cached Biology Technology:CMU Receives $1.2 Million NIH Grant To Develop Ethics, Policy Recommendations for Post-Conflict, Post-Disaster DNA ID Practices 2CMU Receives $1.2 Million NIH Grant To Develop Ethics, Policy Recommendations for Post-Conflict, Post-Disaster DNA ID Practices 3CMU Receives $1.2 Million NIH Grant To Develop Ethics, Policy Recommendations for Post-Conflict, Post-Disaster DNA ID Practices 4New England Biolabs Develops Novel Small RNA NGS Protocol: Reagents Improve Yield and Decrease Adaptor-Dimer Formation 2Elixir Bio-Tech Inc. Elected One of Top 50 Emerging Companies by 100 Venture Capital Funds & Angel Investors 2
EDTA, tetrasodium salt, 1 kg. Ethylene diaminetetraacetic acid.Dihydrate. Assay: 99-101% (as is).Risks: 36, 37, 38 ; Safety Precautions: 22, 36, 37. Category: Nucleotides & Enzymes & Biochemicals, Ul...
EDG-1 Western blot control Source: Cell Lysate Application: Western Blotting Control...
...
Kit containing positive control DNA all parts of the HIV-1 genome, HIV-1 negative control DNA, Primers SK38, SK39, SK19...
Biology Products: