The research team explored use of ribose and NADH supplements as treatments for autism in two parallel studies using ribose and NADH.
One study investigated the effect of supplementation with NADH, an important co-factor for many enzymatic reactions in the body.
Another study investigated the effect of supplementation with ribose, a special sugar made by the body from glucose.
The studies found use of ribose and NADH supplements had similar effects, boosting levels of methylation, glutathione and ATP after only two weeks of therapy.
Levels of ribose and NADH also improved substantially, without adverse effects. After just two weeks of therapy, one child in each group was reported to have some improvement in energy level.
The biochemistry of both NADH and ribose is well-established, as well as how both affect production of ATP, glutathione and methylation. Details are provided in the article in Autism Insights.
Adams points out that both treatments use products that are available as over-the-counter nutritional supplements.
Larger and more formal studies are needed to confirm the benefits of ribose and NADH supplements, Freedenfeld says.
But "these therapies appear to be safe and effective supportive therapies for restoring methylation, glutathione and ATP to near-normal levels in the body, and are likely to help children with autism who experience problems maintaining normal functions," he says.
|Contact: Joe Kullman|
Arizona State University