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Therapeutic nanoparticles give new meaning to sugar-coating medicine
Date:9/22/2009

are more strongly magnetic and tend to clump together, which makes them large enough to attract the body's defense systems before they can reach a tumor. The companies' nanoparticles, however, did not have this problem."

Neutron scattering probes at the NIST Center for Neutron Research revealed that the particles' larger iron oxide cores attract one another, but that the sugar coating has fibers extending out, making it resemble a dandelionand these fibers push against one another when two particles get too close together, making them spring apart and maintain an antibody-defying distance rather than clumping. Moreover, when the particles do get close, the iron oxide centers all rotate together under the influence of a magnetic field, both generating more heat and depositing this heat locally. All these factors helped the nanoparticles destroy breast tumors in three out of four mice after one treatment with no regrowth.

"The push-pull is part of a tug of war that fixes the distance between nanoparticles," Dennis says. "This suggests we can stabilize interacting particles in ways that potentially pay off in the clinic."


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Contact: Chad Boutin
boutin@nist.gov
301-975-4261
National Institute of Standards and Technology (NIST)
Source:Eurekalert

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