Navigation Links
Therapeutic nanoparticles give new meaning to sugar-coating medicine
Date:9/22/2009

A research team at the National Institute of Standards and Technology (NIST) studying sugar-coated nanoparticles for use as a possible cancer therapy has uncovered a delicate balancing act that makes the particles more effective than conventional thinking says they should be. Just like individuals in a crowd respecting other people's personal space, the particles work because they get close together, but not too close.

In cooperation with colleagues at The Johns Hopkins University, Dartmouth College, the University of Manitoba and two biopharmaceutical companies, the NIST team has demonstrated* that the particlesessentially sugar-coated bits of iron oxide, about 100 nanometers wideare potent cancer killers because they interact with one another in ways that smaller nanoparticles do not. The interactions, thought by many bioengineers to be undesirable, actually help the larger particles heat up better when subjected to an alternating magnetic field. Because this heat destroys cancer cells, the team's findings may help engineers design better particles and treatment methods.

Nanoparticles hold the promise of battling cancer without the damaging side effects of chemotherapy or radiation treatment. Minuscule balls of iron oxide can be coated with sugar molecules making them particularly attractive to resource-hungry cancer cells. Once the particles are injected, cancer cells would then ingest them, and doctors would then be able to apply an alternating magnetic field that causes the iron oxide centers to heat, killing the cancer but leaving surrounding tissue unharmed.

Two biotech companies, Micromod Partikeltechnologie and Aduro BioTech, created particles that showed great potential in treating cancers in mice, and they asked NIST to help understand why it worked so well. "But they sent us particles that were much larger than what the conventional wisdom says they should be," says NIST materials scientist Cindi Dennis. "Larger particles
'/>"/>

Contact: Chad Boutin
boutin@nist.gov
301-975-4261
National Institute of Standards and Technology (NIST)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Natural compounds, chemotherapeutic drugs may become partners in cancer therapy
2. Finding the ZIP-code for gene therapy: Scientists imitate viruses to deliver therapeutic genes
3. Neurimmune Therapeutics Announces Advancement of Alzheimers Program into Preclinical Development
4. New DNA and RNA aptamers offer unique therapeutic advantages
5. Got zinc? New zinc research suggests novel therapeutic targets
6. Stem cell research: From molecular physiology to therapeutic applications
7. Triggering muscle development -- a therapeutic cure for muscle wastage?
8. New nanoparticles could revolutionize therapeutic drug discovery
9. Amarna Therapeutics B.V. and TNO announce SVac research and development partnership
10. Continuous glucose monitoring technology -- special issue of Diabetes Technology and Therapeutics
11. NIH announces new program to develop therapeutics for rare and neglected diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2014)... , Dec. 3, 2014  Crossmatch™, a leading ... that its DigitalPersona ® Pro Enterprise software ... been deployed throughout First Bank branch locations in ... South Carolina and Virginia. First Bank, a ... Southern Pines, North Carolina , selected the ...
(Date:12/3/2014)... GLENDALE, Ariz. , Dec. 2, 2014 ... biometric hand readers, Inception Technologies is pleased to announce ... it easier for customers to collect the workforce data ... the problems that have been left by existing readers. ... to user interface, connectivity and modern technology. Older models ...
(Date:11/21/2014)... 2014  Earlier this year Donald Spector , ... one of the most prolific inventors in the world, ... from Smartphones to third party agencies. Spector envisioned this ... of the earliest known patents in this area. Now ... military, child care, elder care and hospital applications. This ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Inception Technologies to Release New Biometric Reader 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... smoke for a prolonged period of time and in ... even in women who never smoked cigarettes themselves. ... could increase risk of breast cancer is one that ... at the Northern California Cancer Center,s Berkeley office. "While ...
... forest,s woodland herb population has shown that climate may ... logging, according to Purdue University research. Despite heavy ... ago, the distribution of trillium plants on the secondary ... Michael Jenkins, a Purdue assistant professor of forestry and ...
... Georgia College of Veterinary Medicine have made an ... for treating Ichthyophthirius multifiliis, or "Ich", a devastating ... With the aid of whole-genome sequencing, researchers ... bacteria: Bacteroides, which are usually found free-living, ...
Cached Biology News:Exposure to secondhand cigarette smoke over a lifetime increased breast cancer risk later in life 2Study finds logging effects vary based on a forest's history, climate 2UGA researchers lead team in discovery involving devastating freshwater fish parasite, 'Ich' 2UGA researchers lead team in discovery involving devastating freshwater fish parasite, 'Ich' 3
(Date:12/24/2014)... Diego, CA (PRWEB) December 23, 2014 ... where their Twitter followers can submit their #HolidayInTheLab ... themselves and their lab mates. , For those struggling ... lab mates, the Pipette.com Holiday in the Lab Contest ... Pipette.com Twitter followers to send pictures of ...
(Date:12/24/2014)... 23, 2014 Sigma-Aldrich Corporation (NASDAQ: ... period under the Hart-Scott-Rodino Antitrust Improvements Act (HSR ... December 22, 2014, thereby completing the U.S. HSR ... acquisition of the Company by Merck KGaA, Darmstadt, ... another condition to closing the transaction, which remains ...
(Date:12/22/2014)... ROCKVILLE, Md. , Dec. 22, 2014 ... MKT: SYN), a developer of pathogen-specific therapies ... focus on protecting the microbiome, today announced ... a Phase 1a clinical trial of SYN-004, ... the prevention of Clostridium difficile (C. ...
(Date:12/22/2014)... 22, 2014  ( www.competitivehealth.com ) — Competitive Health ... bill review and advocacy service, has signed an agreement ... Savings discount health services marketplace. 63% of ... than they expected to pay. As part of an ... WellCard Savings is pleased to offer medical bill review ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2
... (Amex: NBS ),announced today that the new Southern Florida ... Miami, is targeted to open in,September. The center is being ... of this center, NeoStem has secured a key geographic,stronghold in ... as well as a,growing sophisticated South American presence., Chester ...
... Techne Corporation,s,(Nasdaq: TECH ) consolidated net earnings ... $27.3 million or $.70 per diluted share compared,with $22.9 ... ended June 30,2007. For the fiscal year ended June ... million or $2.64 per diluted share,compared with $85.1 million ...
... Life Sciences Inc.,(TSX:PLI) ("ProMetic") announces today that ... integrated, U.S.-based, biotechnology company with respect to,the ... in ProMetic,s Protein Technology Division., In ... as well as,on-going royalties on sales of ...
Cached Biology Technology:NeoStem Forges Ahead in Its Plan to Open Adult Stem Cell Collection Centers in Key Locations that Can Serve as Hubs to Service Clients Nationwide 2NeoStem Forges Ahead in Its Plan to Open Adult Stem Cell Collection Centers in Key Locations that Can Serve as Hubs to Service Clients Nationwide 3Techne Corporation Releases Unaudited Fourth Quarter Results for Fiscal Year 2008 2Techne Corporation Releases Unaudited Fourth Quarter Results for Fiscal Year 2008 3Techne Corporation Releases Unaudited Fourth Quarter Results for Fiscal Year 2008 4Techne Corporation Releases Unaudited Fourth Quarter Results for Fiscal Year 2008 5Techne Corporation Releases Unaudited Fourth Quarter Results for Fiscal Year 2008 6Prometic reaches understanding for commercialisation of several biopharmaceutical products and strategic investment 2Prometic reaches understanding for commercialisation of several biopharmaceutical products and strategic investment 3
Human peripheral blood CD14+ monocytes, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Human endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Yeast tRNA 50 l...
Human monocyte-derived dendritic cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Biology Products: