Navigation Links
Therapeutic nanoparticles give new meaning to sugar-coating medicine

A research team at the National Institute of Standards and Technology (NIST) studying sugar-coated nanoparticles for use as a possible cancer therapy has uncovered a delicate balancing act that makes the particles more effective than conventional thinking says they should be. Just like individuals in a crowd respecting other people's personal space, the particles work because they get close together, but not too close.

In cooperation with colleagues at The Johns Hopkins University, Dartmouth College, the University of Manitoba and two biopharmaceutical companies, the NIST team has demonstrated* that the particlesessentially sugar-coated bits of iron oxide, about 100 nanometers wideare potent cancer killers because they interact with one another in ways that smaller nanoparticles do not. The interactions, thought by many bioengineers to be undesirable, actually help the larger particles heat up better when subjected to an alternating magnetic field. Because this heat destroys cancer cells, the team's findings may help engineers design better particles and treatment methods.

Nanoparticles hold the promise of battling cancer without the damaging side effects of chemotherapy or radiation treatment. Minuscule balls of iron oxide can be coated with sugar molecules making them particularly attractive to resource-hungry cancer cells. Once the particles are injected, cancer cells would then ingest them, and doctors would then be able to apply an alternating magnetic field that causes the iron oxide centers to heat, killing the cancer but leaving surrounding tissue unharmed.

Two biotech companies, Micromod Partikeltechnologie and Aduro BioTech, created particles that showed great potential in treating cancers in mice, and they asked NIST to help understand why it worked so well. "But they sent us particles that were much larger than what the conventional wisdom says they should be," says NIST materials scientist Cindi Dennis. "Larger particles are more strongly magnetic and tend to clump together, which makes them large enough to attract the body's defense systems before they can reach a tumor. The companies' nanoparticles, however, did not have this problem."

Neutron scattering probes at the NIST Center for Neutron Research revealed that the particles' larger iron oxide cores attract one another, but that the sugar coating has fibers extending out, making it resemble a dandelionand these fibers push against one another when two particles get too close together, making them spring apart and maintain an antibody-defying distance rather than clumping. Moreover, when the particles do get close, the iron oxide centers all rotate together under the influence of a magnetic field, both generating more heat and depositing this heat locally. All these factors helped the nanoparticles destroy breast tumors in three out of four mice after one treatment with no regrowth.

"The push-pull is part of a tug of war that fixes the distance between nanoparticles," Dennis says. "This suggests we can stabilize interacting particles in ways that potentially pay off in the clinic."


Contact: Chad Boutin
National Institute of Standards and Technology (NIST)

Related biology news :

1. Natural compounds, chemotherapeutic drugs may become partners in cancer therapy
2. Finding the ZIP-code for gene therapy: Scientists imitate viruses to deliver therapeutic genes
3. Neurimmune Therapeutics Announces Advancement of Alzheimers Program into Preclinical Development
4. New DNA and RNA aptamers offer unique therapeutic advantages
5. Got zinc? New zinc research suggests novel therapeutic targets
6. Stem cell research: From molecular physiology to therapeutic applications
7. Triggering muscle development -- a therapeutic cure for muscle wastage?
8. New nanoparticles could revolutionize therapeutic drug discovery
9. Amarna Therapeutics B.V. and TNO announce SVac research and development partnership
10. Continuous glucose monitoring technology -- special issue of Diabetes Technology and Therapeutics
11. NIH announces new program to develop therapeutics for rare and neglected diseases
Post Your Comments:
(Date:6/22/2016)... , June 22, 2016   Acuant ... and verification solutions, has partnered with RightCrowd ... solutions for Visitor Management, Self-Service Kiosks and ... products that add functional enhancements to existing ... corporations and venues with an automated ID ...
(Date:6/16/2016)... 2016 The global ... reach USD 1.83 billion by 2024, according to ... Technological proliferation and increasing demand in commercial buildings, ... drive the market growth.      (Logo: ... development of advanced multimodal techniques for biometric authentication ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... innovative medical technologies, services and solutions to the healthcare market. The company's primary ... various distribution, manufacturing, sales and marketing strategies that are necessary to help companies ...
(Date:6/27/2016)... , June 27, 2016  Liquid Biotech ... the funding of a Sponsored Research Agreement with ... tumor cells (CTCs) from cancer patients.  The funding ... CTC levels correlate with clinical outcomes in cancer ... data will then be employed to support the ...
(Date:6/24/2016)... , June 24, 2016  Regular discussions on a range ... place between the two entities said Poloz. Speaking ... Ottawa , he pointed to the country,s inflation ... federal government. "In ... "Both institutions have common economic goals, why not sit down ...
(Date:6/24/2016)... , ... June 24, 2016 , ... While the majority ... as the Cary 5000 and the 6000i models are higher end machines that use ... height of the spectrophotometer’s light beam from the bottom of the cuvette holder. ...
Breaking Biology Technology: