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Therapeutic AIDS vaccine designed by HIVACAT reduces the viral load in the majority of AIDS patients
Date:2/1/2011

niversity of Barcelona. The vaccine was administered in 3 dosis with an interval of 2 weeks between each one.

At the end of 24 weeks, it showed that the majority of patients had experienced a significant decrease in the viral load. This decrease was very significant is some of them but in no case did the virus become undetectable. However this is a very important improvement with respect to previous initiatives where with a similar vaccine there was a modest response in 30% of the treated patients. No therapeutic vaccine has achieved up to now the same level of response as in this study. A new clinical trial is underway testing the administration of the vaccine in conjunction with antiretroviral drugs to allow an improvement in the results.

The principal objective of therapeutic vaccines is to minimize the need for antiretroviral drug treatment. These treatments have improved enormously over the past few years and have become easy drugs to administer with few side effects. Although the daily administering is not ideal, there is no experience over the long term and it is not known if the treatment could bring about resistance. It aims to deal with the treatment of chronic patients for their whole life which currently is an important economic burden for the health system. The annual budget for antiretrovirals in Hospital Clinic is around 30 Million Euros. Furthermore the therapeutic vaccine is easy to produce and small administrations could be implemented in developing countries, too. To undertake this ambitious objective there has to be a continuing scientific and economic efforts in initiatives such as HIVACAT.


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Contact: Alex Argemi
aargemi@clinic.ub.es
34-932-275-700
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer
Source:Eurekalert

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