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Therapeutic AIDS vaccine designed by HIVACAT reduces the viral load in the majority of AIDS patients
Date:2/1/2011

The therapeutic vaccines are a priority research line of the HIVACAT, the catalan programme for the development of therapeutic vaccines and prevention against the Human Immunodeficiency Virus (HIV). This type of therapeutic vaccine helps the patients who are carriers of the virus, combat infection and control the appearance of AIDS in the same way as with the current antiretroviral treatments. The final aim of the therapeutic vaccines will be to avoid a life long treatment with antiretroviral drugs. The research team 'Infectious Diseases and AIDS' led by Dr. Josep Maria Gastell from IDIBAPS Hospital Clnic has developed using the brand HIVACAT, a model of the therapuetic vaccine based on the patient's own dendritic cells. This reduction in the viral load is still considered to be insuficient but it is the first therapeutic vaccine which has achieved a postive response in the majority of patients.

The Journal of Infectious Diseases has published the results of this study with Dr. Felipe Garca from the Infectious Diseases Unit of IDIBAPS Hospital Clinic, as first author and Dr. Teresa Gallart from the Immunology Laboratoy of the same centre as last author. The work counted on an international collaboration with teams from France, the Hpital Piti-Salptrire and the Universit Pierre et Marie Curie in Paris/INSERM, and the USA, the National Institute of Cancer in Maryland.

A total of 24 patients participated in this double blind clinical trial, half of whom formed the control Group and who did not receive the vaccine. None of these patients received antiretroviral treatment and to enter into the study had to maintain a good T lymphatic blood load (>450 per mm3). The vaccine was personalized and was made from the dendritic cells of each patient sensitized in the laboratory against an inactive form of their own virus. We are looking at a cell therapy that in the ambit of IDIBAPS received support from the Cell Therapy programme of the U
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Contact: Alex Argemi
aargemi@clinic.ub.es
34-932-275-700
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer
Source:Eurekalert

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