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The yin and yang in the life of proteins
Date:10/22/2013

sferred by the E2 enzyme and, eventually, coordinated by the E3 enzyme to dock with the receptor. By analysing yeast cells, the Bochum physicians found out that E2 and E3 enzymes occur in different variations, whereas there is only one type of the E1 enzyme. The docking of one single ubiquitin and an ubiquitin chain is determined by different combinations of E2 and E3 enzymes. "That means two opposing molecular machines determine the fate of the import receptor Pex18," says Harald Platta. "This discovery illustrates just how precisely the receptor's control is calibrated and how precisely the regulation associated with it is effected for the entire peroxisomal function. This project constitutes a crucial foundation for further research into the molecular causes of peroxisomal disorders."

Peroxisomes: The cell's multi-functional tools

Peroxisomes are important reaction states within the cell. They may contain up to 50 enzymes which are crucial for breaking down of fatty acids, for the disposal of hydrogen peroxide and the generation of plasmalogens which are an important component of the brain's white matter. A disruption of the protein import in peroxisomes has a negative impact on the entire metabolism and may be fatal especially for newborns.


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Contact: Dr. Harald W. Platta
Harald.Platta@rub.de
49-234-322-4968
Ruhr-University Bochum
Source:Eurekalert

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