Navigation Links
The yin and yang in the life of proteins
Date:10/22/2013

Recycling or "scrap press": physicians at the Ruhr-Universitt have found out which molecular mechanisms decide about the fate of the import receptor Pex18. Pex18 is responsible for the import of proteins into specific cell components, namely peroxisomes. Two opposing regulatory circuits determine whether the receptor remains active or is broken down after the transport has been completed. "Thus, the picture of the regulation of the protein import into peroxisomes has been completed and integrated to form one single model," says Junior Professor Dr Harald Platta from the RUB Faculty of Medicine. Together with Prof Dr Ralf Erdmann and other colleagues he reports in the journal "Traffic".

Ubiquitin signals determine the fate of the receptors

Because they don't have their own DNA, peroxisomes have to import all proteins that are necessary for them to fulfil their function. For this purpose, the cell is equipped with dynamic import receptors such as Pex18. They bind proteins in the cytoplasm and transport them to the peroxisome. The RUB team had demonstrated in a previous study that the signal protein ubiquitin subsequently decides about the future fate of the receptors: if a single ubiquitin protein docks with the receptor, the receptor gets recycled; it migrates back into the cytoplasm and launches a new transport process. If an ubiquitin chain docks with the receptor, a signal is sent out for the receptor to be broken down by the proteasome, an "intracellular scrap press", so to speak. Prior to this discovery, it had not been understood in what way the cell determines on the molecular level what happens to the receptor.

Recycling or "scrap press": It all depends on the enzyme cascade

The RUB physicians found out that different enzyme cascades catalyse the two ubiquitin modifications of Pex18. In both cases, it is a three-step process: the E1 enzyme activates the ubiquitin signal which is subsequently tran
'/>"/>

Contact: Dr. Harald W. Platta
Harald.Platta@rub.de
49-234-322-4968
Ruhr-University Bochum
Source:Eurekalert

Page: 1 2

Related biology news :

1. Zinc, proteins, and an essential cellular balancing act
2. Erratic proteins: New insights into a transport mechanism
3. Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
4. Scientists decipher cellular roadmap of disease-related proteins
5. Toronto team IDs proteins key in stem cell production
6. Toronto team ID proteins key in stem cell production
7. Low levels of toxic proteins linked to brain diseases, study suggests
8. National Institutes of Health to fund research probing proteins linked to cancer, diabetes
9. Saliva proteins may protect older people from influenza
10. KISS ME DEADLY proteins may help improve crop yields
11. Metabolic fingerprinting: Using proteomics to identify proteins in gymnosperm pollination drops
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 15, 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a ... introduces for the first time a fingerprint sensor in ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced today its ... confirm its adherence to current U.S. Food and Drug ... regulated smart device and smart phone application trials utilizing ... "HITLAB is determined to improve global healthcare ...
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) has ... Market 2015-2019" report to their offering. ... trend upcoming in this market is the increasing demand ... in recording of patient data for quick and correct ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... the power of 21st century computing to confirm an idea ... cycles evolve faster. Their findings appear in the October 3rd ... consequence for the understanding of evolution made possible by the ... said senior author Michael Donoghue , the G. Evelyn ...
... Using computer models and live cell experiments, biomedical engineers at ... than 100 human protein fragments that can slow or stop ... Reporting online last week in the Proceedings ... the findings could lead to developing treatments to fight diseases ...
... has confirmed the appointment of Esin Gulari, dean of the ... on the National Science Board (NSB). President George W. Bush ... scientists. "This is a tremendous honor for me as ... I will be in a unique position to make contributions ...
Cached Biology News:Reproducing early and often is the key to rapid evolution in plants 2Discovery of natural compounds that could slow blood vessel growth 2US Senate confirms Clemson University engineering Dean Esin Gulari to National Science Board 2
(Date:1/22/2015)... Diagenode, Inc., a leading global provider ... complete solutions for epigenetics research, recently launched a ... need for manual processing. The new ChIPettor System ... histones or transcription factors and a semi-automated pipette ...
(Date:1/22/2015)... DIEGO , Jan. 22, 2015   Cypher ... and Sequenom, Inc. (NASDAQ: SQNM ), ... development agreement for next generation noninvasive prenatal tests ... genome interpretation technology, called Mantis™, to advance analysis ...
(Date:1/22/2015)... 22, 2015   GenoSpace , a precision medicine software company ... the broad use of genomic, imaging and other biomedical data ... Michelle Munson , CEO of Aspera, an IBM Company, ... - http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased ...
(Date:12/25/2014)... The report “Service Quality Management and Telco ... Type - Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” ... and forecasting of revenues. , Browse 152 market ... in-depth TOC on “Service Quality Management (SQM) and Telco ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... Wis. - The Fitchburg Plan Commission has recommended approval ... building and data center that would accommodate the expansion of ... the anchor tenant in both buildings, which are planned for ... Fitchburg Technology Campus . , ,The plans, which now go ...
... hero, she was heading to the tiny island nation of ... Indian Ocean. By all reports and expectations, she would be off ... disconnection. , ,Or maybe not. After 36 hours in ... made our way through customs and out into the humid night ...
... - Tanya Townsend didn't have much time to pass the ... many other information technology directors have an opportunity to start ... and new processes? , ,Not many, and when the ... shopping for a chief technology executive in 2004, Townsend beat ...
Cached Biology Technology:Berbee to expand at New Venture Center 2Coveted vacation "disconnect" was elusive 2Coveted vacation "disconnect" was elusive 3CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital 2CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital 3CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital 4CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital 5
sterile filtered, off the clot, all male donors, Total Protein: 4.5 to 8.5 g/dl...
One-step, colorimetric, linear detection range 0.7 mg/dL to 300 mg/dL. Procedure: 10 min....
Human alpha-1-antitrypsin. No cross-reactivity with alpha-1-acid glycoprotein, serum albumin or other serum proteins....
Recombinant Mouse LIGHT/TNFSF14...
Biology Products: