"Our label-free colorimetric sensor eliminates the need of problematic fluorescence tagging of DNA/ protein molecules, and the hybridization of probe and target molecule is detected from the color change of the sensor," stated Manas Gartia, first author of the article, "Colorimetrics: Colorimetric Plasmon Resonance Imaging Using Nano Lycurgus Cup Arrays." "Our current sensor requires just a light source and a camera to complete the DNA sensing process. This opens the possibility for developing affordable, simple and sensitive mobile phone-based DNA microarray detector in near future. Due to its low cost, simplicity in design, and high sensitivity, we envisage the extensive use of the device for DNA microarrays, therapeutic antibody screening for drug discovery, and pathogen detection in resource poor setting."
Gartia explained that light-matter interaction using sub-wavelength hole arrays gives rise to interesting optical phenomena such as surface plasmon polaritons (SPPs) mediated enhanced optical transmission (EOT). In case of EOT, more than expected amount of light can be transmitted through nanoholes on otherwise opaque metal thin films. Since the thin metal film has special optical property called surface plasmon resonance (SPR) which is affected by tiny amount surrounding materials, such device has been used as biosensing applications.
According to the researchers, most of the previous studies have mainly focused on manipulating in-plane two-dimensional (2D) EOT structures such as tuning the hole diameter, shape, or distance bet
|Contact: Logan Liu|
University of Illinois College of Engineering