Navigation Links
The world is not flat: Exploring cells and tissues in three dimensions
Date:10/19/2010

ted by the movement of fluids over cell surfaces and has been found to play an important role in cellular differentiation, development and function. Intriguingly, experimental research carried out by Nickerson and her team has implicated low-fluid shear environments in regulating the infectious disease potential of certain human pathogens. Specifically, conditions encountered by pathogens in certain areas of the gastrointestinal, respiratory and urogenital tracts represent low fluid shear environments that have the potential to alter the outcome of the infectious disease process.

Over the past decade, the Nickerson group and colleagues have published their 3-D models of the small and large intestine, lung, placenta, neuronal tissue and vaginal epithelium. Such models offer exciting new insights into cell proliferation, differentiation and immune function, and are providing a platform to understand normal tissue homeostasis and transition to disease. Furthermore, these 3-D models have also unveiled new ways that pathogens cause disease and have expanded the range of pathogens that can be studied in vitro. Essential to this line of research, 3-D models respond to infection in important ways that mimic the infected host.

These studies include infection of 3-D intestinal tissues by food-borne bacterial and viral pathogens including Salmonella typhimurium and norovirus, respectively, and infection of 3-D lung tissues by the bacterial pathogen Pseudomonas aeruginosa. Nickerson stresses that 3-D tissue modeling has opened the door to examining a variety of host-pathogen interactions that were previously difficult or impossible to study through conventional means.

Nickerson also sees a promising future for 3-D cell cultures in facilitating the translation of basic science to the clinical setting. She emphasizes that the development and use of a series of increasingly complex 3-D model systems that incorporate multiple cell types will enable th
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Image of mosquitos heart wins first place in Nikons Small World photomicrography competition
2. Team completes world-first ocean observatory
3. Yale scientist helps pinpoint threats to life in worlds rivers
4. International Rectal Microbicide Advocates cheers launch of worlds third rectal microbicide trial
5. WUSTLs Living Learning Center shares the worlds first full Living Building certification
6. Microscopic solutions to worlds biggest problems
7. Land evapotranspiration taking unexpected turn: huge parts of world are drying up
8. Life-saving in the bacterial world: How Campylobacter rely on Pseudomonas to infect humans
9. UW-built device reveals invisible world teeming with microscopic algae
10. Keeping a watch on the world
11. The world is full of darkness, reflected in the physiology of the human retina, Penn researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The world is not flat: Exploring cells and tissues in three dimensions
(Date:9/16/2014)... Scotland votes for independence later this week, its Government ... people that fracking is necessary, research has revealed. , ... tracking public perception of shale gas extraction in the ... living north of the border are the least supportive ... research in the University,s School of Geography, said: "The ...
(Date:9/16/2014)... From the salmon-rich waters of Southeast Alaska to ... Downeast Maine,s lobster, lumber and tourist towns, coastal residents ... about coastal environments divide along political lines. That,s a ... New Hampshire sociologists published this month in the journal ... a lot of environment-related differences from place to place ...
(Date:9/16/2014)... years ago, the Exxon Valdez spilled 11 million gallons ... themselves cleaning up another giant oil spill in the ... study in the Journal of Consumer Research , ... immediate anxieties instead of catalyzing changes in the way ... national news media coverage of these two events helped ...
Breaking Biology News(10 mins):Scottish people most sceptical on fracking, survey shows 2Scottish people most sceptical on fracking, survey shows 3Politics divide coastal residents' views of environment, UNH research finds 2Politics divide coastal residents' views of environment, UNH research finds 3Exxon Valdez 2014: Does media coverage of manmade disasters contribute to consumer complacency? 2
... summer for sports, fans. World records tumbled at the ... 200m world records, knocking tenths of a second off ... the last few decades, which made marathon runner Mark ... increase in population could account for these dramatic improvements. ...
... genetic polymorphisms induce major differentiations in the metabolic ... paper published November 28 in the open-access journal ... of researchers, led by Karsten Suhre, has conducted ... variants in genes involved in the breakdown of ...
... A new and insidious environmental threat has been ... Queen,s and York universities. Along with scientists ... documented biological damage caused by declining levels of ... the phenomenon "aquatic osteoporosis," Queen,s PhD candidate Adam ...
Cached Biology News:100-meter sprint world record could go as low as 9.48 seconds 2Study identifies genetic variants giving rise to differences in metabolism 2Queen's University biologists find new environmental threat in North American lakes 2
(Date:9/15/2014)... United States (PRWEB) September 16, 2014 ... Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies is ... This report focuses on the three principal types ... of research and development in cancer immunotherapy (which ... inhibitors, Therapeutic anticancer vaccines and Adoptive cellular immunotherapy. ...
(Date:9/15/2014)... 2014  FlexTech Alliance today issued a dual-focused ... demonstrators (demos) and a functional electronic print leaflet.  ... due on October 22, 2014 and full proposals ... selected are provided by the US Army Research ... by the proposing organization. Photo - ...
(Date:9/15/2014)... has sepsis, a life-threatening condition in which bacteria or ... fast for antibiotics to help. A new device inspired ... at Harvard,s Wyss Institute for Biologically Inspired Engineering may ... "Even with the best current treatments, sepsis patients are ... of the time," said Mike Super, Ph.D., Senior Staff ...
(Date:9/15/2014)... interdisciplinary team of researchers led by Northeastern University ... precise inter-nanotube junctions and a variety of nanocarbon ... facile and easily scalable, which will allow the ... networks for use in applications ranging from electronic ... from cars to sports equipment. , Their findings ...
Breaking Biology Technology:Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 2Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 3Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 4Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 5FlexTech Alliance Issues 2015 Request for Proposals in Flexible, Printed Electronics 2Blood-cleansing biospleen device developed for sepsis therapy 2Blood-cleansing biospleen device developed for sepsis therapy 3Blood-cleansing biospleen device developed for sepsis therapy 4Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2
... Inc. (Nasdaq: ECTE ), a company developing ... continuous glucose monitoring (tCGM) system and the Prelude® SkinPrep ... from its clinical study of its Symphony tCGM System ... Data from the study confirm that Symphony successfully monitors ...
... create electrical components like resistors, transistors and diodes, that ... Nongjian (NJ) Tao, a researcher at the Biodesign Institute ... molecules may also allow clever designers to produce novel ... conventional electronics. In research appearing in today,s ...
... YORK, Dec. 5, 2011 Levi & Korsinsky is ... securities of Pacific Biosciences of California, Inc. ("PacBio" or ... violations of federal securities laws. For more ... The investigation stems from allegations that the Company failed ...
Cached Biology Technology:Echo Therapeutics Announces Positive Results of Clinical Trial of its Symphony® Transdermal Continuous Glucose Monitoring (tCGM) System in Patients With Type 1 and Type 2 Diabetes 2Echo Therapeutics Announces Positive Results of Clinical Trial of its Symphony® Transdermal Continuous Glucose Monitoring (tCGM) System in Patients With Type 1 and Type 2 Diabetes 3Echo Therapeutics Announces Positive Results of Clinical Trial of its Symphony® Transdermal Continuous Glucose Monitoring (tCGM) System in Patients With Type 1 and Type 2 Diabetes 4S-t-r-e-t-c-h-i-n-g electrical conductance to the limit 2S-t-r-e-t-c-h-i-n-g electrical conductance to the limit 3The Law Firm of Levi & Korsinsky, LLP Launches an Investigation Into Possible Securities Laws Violations by Pacific Biosciences of California, Inc. 2
... Decorin ( Abpromise for all ... Synthetic peptide: IGPEVPDDRDFEPS conjugated to ... of Human Decorin (fragment 36-49 of ... Entrez GeneID: ...
GLP expression profiling service on the Affymetrix platform. Starting material can be blood, tissue or RNA. 5 day turnaround. Standard and custom post analyses of microarray data available....
... System is a fluorescent microscopy-based imaging system ... cells and automatically calculates cell viability, in ... routine function, the variability associated with the ... eliminated. Using the EasyCount ViaSure Kit, up ...
In Western blotting antibodies recognize 94 K protein band, which corresponds to S-layer protein...
Biology Products: