Navigation Links
The world is not flat: Exploring cells and tissues in three dimensions
Date:10/19/2010

The cells and tissues in our bodies grow, develop and interact in a highly complex, three-dimensional world. Likewise, the various microbial pathogens that invade our bodies and cause infectious disease interact with this complex 3-D tissue milieu. Yet the methods of culturing and studying human cells have traditionally been carried out in two dimensions on flat impermeable surfaces. While such 2-D culturing and modeling efforts have produced a steady stream of critical insight into cell behavior and the mechanisms of infection and disease, 2-D cell cultures have key limitations in terms of accurately reproducing the tissue environment in vivo, that is, the environment found within a living organism.

In the current issue of the journal Nature Reviews Microbiology, researcher Cheryl Nickerson and her team at the Biodesign Institute at Arizona State University highlight an innovative approach for studying cells in 3-D. They are examining the potential of such research to greatly expand science's understanding of disease onset and progression, particularly the responses of host cells to infectious pathogens. Such work provides fresh insight into the mechanisms of infectious disease and holds the potential for the design of novel or improved therapeutics, more accurate drug screening and improved evaluation of potential vaccine candidates.

Despite enormous progress in understanding how infectious pathogens successfully evade the immune system and cause disease, and the successful treatment or eradication of some of these deadly illnesses; infectious diseases remain a huge health and economic burden, particularly in the developing world. They continue to cause roughly 35 percent of all fatalities worldwide, killing some 14-17 million people annually. Many of these deaths could be prevented through the development of in vitro models of human cells and tissues that better mimic in vivo environments.

Before the advent of 3-D c
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Image of mosquitos heart wins first place in Nikons Small World photomicrography competition
2. Team completes world-first ocean observatory
3. Yale scientist helps pinpoint threats to life in worlds rivers
4. International Rectal Microbicide Advocates cheers launch of worlds third rectal microbicide trial
5. WUSTLs Living Learning Center shares the worlds first full Living Building certification
6. Microscopic solutions to worlds biggest problems
7. Land evapotranspiration taking unexpected turn: huge parts of world are drying up
8. Life-saving in the bacterial world: How Campylobacter rely on Pseudomonas to infect humans
9. UW-built device reveals invisible world teeming with microscopic algae
10. Keeping a watch on the world
11. The world is full of darkness, reflected in the physiology of the human retina, Penn researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The world is not flat: Exploring cells and tissues in three dimensions
(Date:7/10/2014)... June 27, 2014  The American Academy of ... of Standards and Technology (NIST) and the Department ... research and forensic science expert members to the ... an element of the NIST,s Organization of Scientific ... the first appointments made to the new FSSB ...
(Date:7/10/2014)... June 27, 2014  Pomerantz LLP has filed ... ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain of ... States District Court, Middle District of ... of a class consisting of all persons or ... between December 17, 2013 and May 22, 2014, ...
(Date:7/10/2014)... June 30, 2014  Aware, Inc. (NASDAQ: ... services, previously announced on June 26, 2014 that its ... of $1.75 per share, or approximately $40 million in ... 10, 2014 and a payment date of July 24, ... it had set an ex-dividend date for this special ...
Breaking Biology News(10 mins):Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3NASDAQ Sets Ex-Dividend Date for Aware, Inc.'s Special Cash Dividend of $1.75 Per Share 2
... PHILADELPHIA Electrical engineers have long been toying with ... directly integrated into electronic circuits. University of Pennsylvania researchers ... they can operate in open-air environments, and, more important, ... the electrical properties of these and similar devices. ...
... new challenge as 19 eminent ecologists issue a call ... journal Nature . Often called aliens, hitchhikers ... just as easily be coined "abductees" whose transport links ... Nature comments section note that assumptions that "introduced species" ...
... in German . , They can cause lung ... the exhaust gas of diesel-engined vehicles. The quantity of these ... harmful effects to one,s physical health due to soot particles ... drastically step by step, from 180 mg/km (EURO 1, 1993) ...
Cached Biology News:Penn researchers develop biological circuit components, new microscope technique for measuring them 2Penn researchers develop biological circuit components, new microscope technique for measuring them 3Ecology biased against non-native species? 2Pan-European research project for clean air 2Pan-European research project for clean air 3
(Date:7/10/2014)... , July 10, 2014 Research ... addition of the "International Photonic Integrated Circuit ... Forecasts to 2019" report to their offering. ... The concept of photonic integration traces its ... century. The promise of photonic integration went unexplored ...
(Date:7/10/2014)... WASHINGTON D.C., April 15, 2014 -- According to ... danger to nuclear security comes from terrorists acquiring ... (HEU) to construct a crude nuclear explosive device. ... illicit nuclear trafficking have involved gram-level quantities, which ... methods. , According to a new study appearing ...
(Date:7/10/2014)... 17, 2014 Using microscopic polymer light resonators ... researchers at MIT,s Quantum Photonics Laboratory have developed ... the parts-per-billion range. Optical sensors are ideal for ... signal-to-noise ratio, compact, lightweight nature, and immunity to ... had been developed before, the MIT team conceived ...
(Date:7/10/2014)... basis of psychiatric disorders has been extremely challenging because ... but are insufficient to cause disease. Now investigators reporting ... journal Cell Stem Cell describe a strategy ... interact with other risk factors or environmental exposures to ... pinpoints a genetic variant that may predispose individuals to ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Sensitive detection method may help impede illicit nuclear trafficking 2Swell new sensors 2New strategy could uncover genes at the root of psychiatric illnesses 2
... NanoLogix, Inc.,(OTC Pink Sheets: NNLX) a nano-biotechnology ... director appointment., NanoLogix has posted 2007 unaudited ... while funding for 2007 Research and Development,was increased ... http://www.nanologixinc.com/financials.html , NanoLogix welcomes Bert Pharis to ...
... MEDxConnect(TM) System Enables Transmission of Images and Patient Report,Transfer Across ... ... RIS Crashes, ... healthcare IT systems, announced today the,implementation of an integrated digital ...
... Repligen,Corporation (Nasdaq: RGEN ) announced today that ... BMY ) in its lawsuit alleging,infringement of U.S. ... sale of Orencia(R) for the treatment of rheumatoid,arthritis. The ... of $5,000,000 and to pay royalties on the U.S. ...
Cached Biology Technology:NanoLogix Inc. Provides Financial Update, Appoints Bert Pharis as New Director 2Compressus Completes Interoperability Implementation for E-Rad Solutions Teleradiology Customers 2Compressus Completes Interoperability Implementation for E-Rad Solutions Teleradiology Customers 3Repligen Announces Settlement with Bristol-Myers Squibb in Orencia(R) Lawsuit 2Repligen Announces Settlement with Bristol-Myers Squibb in Orencia(R) Lawsuit 3