Navigation Links
The vasculature emerges as a potential therapeutic target in treating ADPKD liver cysts
Date:9/23/2009

As part of an effort to develop effective medical therapies that block the progression of liver cyst growth in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD), researchers at the University of Colorado Anschutz Medical Center have found that the liver cyst walls develop and maintain a vasculature as they grow out from the body of the liver and that factors released by epithelial cells that line the liver cyst wall lumen can drive the proliferation and development of vascular endothelial cells. The findings, which appear in the October 2009 issue of Experimental Biology and Medicine, are the result of a multi-disciplinary team assembled by Dr. Brian Doctor. Dr. Nick Barry, a biophysicist, and Dr. Ryan McWilliams, a medical resident, employed complimentary imaging techniques to visualize and characterize the vasculature within native liver cyst walls of human ADPKD patients and pkd2(WS25/-) mice, an orthologous mouse model of ADPKD. Kelley Brodsky, a senior research associate, and Dr. Claudia Amura, a cell biologist, then used in vitro assays of endothelial cell proliferation and vascular development to demonstrate that human liver cyst fluids, which contain a variety of cytokines and growth factors secreted by the liver cyst lining epithelium, are capable of driving the angiogenic phenotype of endothelial cells. Further, inhibition of VEGF receptor signaling dramatically impeded this angiogenic phenotype. Dr. Doctor noted that "by establishing the presence of the vasculature within the enlarging liver cyst walls and defining the putative signaling pathways that induce angiogenesis within them, this study opens up an exciting new direction in the quest to develop medical therapies that can block the often devastating growth of liver cysts in patients with ADPKD".

In summary, while there are differences in their vascular density and distribution, both human ADPKD and pkd2(WS25/-) mouse liver cyst walls develop vascular structures
'/>"/>

Contact: Dr. R. Brian Doctor
brian.doctor@ucdenver.edu
303-724-7224
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Venous origin of the mammalian lymphatic vasculature
2. Black carbon pollution emerges as major player in global warming
3. RNA emerges from DNAs shadow
4. Cataloguing invisible life: Microbe genome emerges from lake sediment
5. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
6. Neuronal conduction of excitation without action potentials based on ceramide production
7. To maximize biofuel potential, researchers look for sorghums sweet spot
8. Joslin researchers uncover potential role of leptin in diabetes
9. Chemistry turns killer gas into potential cure
10. Researchers examine worlds potential to produce biodiesel
11. New inhibitor has potential as cancer drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/25/2014)... of Fire and Emergency Services of Western Australia, a bushfire ... 20 kilometres east of Broome, and Cape Leveque Road approximately ... There is no threat to lives or homes but ... There is a complex of fires burning in the area ... Roadhouse. The fires are also burning on the eastern ...
(Date:8/25/2014)... avoid becoming obese or to slim down if ... groups, maintaining a healthy weight can be that much ... an experimental social psychologist at Rutgers University-Newark. , Rivera ... States to endure negative stereotypes, pervasive messages that suggest ... prevent people from doing what is needed to care ...
(Date:8/25/2014)... , Aug. 25, 2014 /PRNewswire-iReach/ -- Baltimore ... therefore has some of the oldest buildings as well. With these ... arise, one of the most prevalent problems happens to be mold. ... homes in Baltimore and in the walls ... the decades. What can one do though to look for mold ...
Breaking Biology News(10 mins):Racial and ethnic stereotypes may contribute to obesity among minorities 2Mold Concerns in Baltimore 2
... can pollinate themselves and reproduce without the aid of a ... the short-term perks of being able to go it alone ... journal Science . The reason is because plants that ... Flowering plants are incredibly creative when it comes to ...
... be the ultimate green factories, engineered to pump out ... petroleum-based chemicals. But in reality, getting plants to accumulate ... goal. Now, in a first step toward achieving industrial-scale ... (DOE) Brookhaven National Laboratory and collaborators at Dow AgroSciences ...
... A monoclonal antibody targeting a well known cell surface ... aggressive form of the disease that did not respond ... with the UCLA Department of Urology and UCLA,s Jonsson ... the protein, N-cadherin, is up regulated or turned on ...
Cached Biology News:Single parenthood doesn't pay off for plants 2Engineered plants make potential precursor to raw material for plastics 2Engineered plants make potential precursor to raw material for plastics 3UCLA researchers discover a potential target for therapy for patients with a deadly prostate cancer 2UCLA researchers discover a potential target for therapy for patients with a deadly prostate cancer 3
(Date:8/27/2014)... Hunting Valley, Ohio (PRWEB) August 27, 2014 ... five students from Cleveland's University School ... at Case Western Reserve University’s School of ... program provides students with an unparalleled professional experience ... with the School of Medicine faculty and students ...
(Date:8/26/2014)... and Bellingham, WA (PRWEB) August 26, 2014 ... engineering, visions for next-generation wearable technology, and inspiration ... numerous highlights at this year’s brighter, busier ... Diego, California, Convention Center. More than 4,400 international ... attended conferences, courses, an exhibition, and industry sessions ...
(Date:8/26/2014)... - A team of engineers from Singapore has ... network (WSN) for satellite communications. , With the ... satellite design, constructing a lightweight, low power-consuming, wireless ... the satellite has always been a challenge for ... Satellite Research Centre of Nanyang Technological University in ...
(Date:8/26/2014)... LONDON , Aug. 26, 2014 An ... gene structures of all Dengue virus strains in Pubmed, ... structures back to 1944. This conservation and sharing of ... a Synthetic Dengue Blocker-Vaccine™ candidate, as it did for ... vaccine, both of which have been found to be ...
Breaking Biology Technology:Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4ZigBee in the Sky 2
... Neogen Corporation,(Nasdaq: NEOG ) announced today ... Inc., of Winnipeg, Canada. Rivard Instruments and Neogen,s,subsidiary, ... hypodermic needles., The acquisition settles lengthy litigation ... each. The patent battles were centered,on lawsuits filed ...
... US and Glivec in Europe and Australia) is used ... and gastrointestinal stromal tumors (GISTs). It can be used ... they are caused by related proteins tyrosine kinases. ... means that imatinib can also inhibit tyrosine kinases that ...
... Dec. 3 Thermo Fisher,Scientific Inc. (NYSE: TMO ... the China Doping Control Center (CDCC) has selected the,company ... software for,the testing of athletes at the 29th Olympic ... Chinese government and the International Olympic,Committee (IOC) to conduct ...
Cached Biology Technology:Neogen Acquires Assets of Rivard Instruments 2Thermo Fisher Scientific Selected by China Doping Control Center to Supply Testing Instrumentation for the 2008 Olympic Games in Beijing 2Thermo Fisher Scientific Selected by China Doping Control Center to Supply Testing Instrumentation for the 2008 Olympic Games in Beijing 3Thermo Fisher Scientific Selected by China Doping Control Center to Supply Testing Instrumentation for the 2008 Olympic Games in Beijing 4
...
...
... Formulation: 50mM Tris-HCl, pH 7.5, ... PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol ... (Protein Phosphatase 2A1) partially purified ... precipitation, QSepharose,amino-hexyl agarose, Superdex 200, ...
Borosilicate Glass. Certified for use with the Beacon 2000 Systems, 1,000 tubes/case...
Biology Products: