Navigation Links
The vasculature emerges as a potential therapeutic target in treating ADPKD liver cysts
Date:9/23/2009

As part of an effort to develop effective medical therapies that block the progression of liver cyst growth in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD), researchers at the University of Colorado Anschutz Medical Center have found that the liver cyst walls develop and maintain a vasculature as they grow out from the body of the liver and that factors released by epithelial cells that line the liver cyst wall lumen can drive the proliferation and development of vascular endothelial cells. The findings, which appear in the October 2009 issue of Experimental Biology and Medicine, are the result of a multi-disciplinary team assembled by Dr. Brian Doctor. Dr. Nick Barry, a biophysicist, and Dr. Ryan McWilliams, a medical resident, employed complimentary imaging techniques to visualize and characterize the vasculature within native liver cyst walls of human ADPKD patients and pkd2(WS25/-) mice, an orthologous mouse model of ADPKD. Kelley Brodsky, a senior research associate, and Dr. Claudia Amura, a cell biologist, then used in vitro assays of endothelial cell proliferation and vascular development to demonstrate that human liver cyst fluids, which contain a variety of cytokines and growth factors secreted by the liver cyst lining epithelium, are capable of driving the angiogenic phenotype of endothelial cells. Further, inhibition of VEGF receptor signaling dramatically impeded this angiogenic phenotype. Dr. Doctor noted that "by establishing the presence of the vasculature within the enlarging liver cyst walls and defining the putative signaling pathways that induce angiogenesis within them, this study opens up an exciting new direction in the quest to develop medical therapies that can block the often devastating growth of liver cysts in patients with ADPKD".

In summary, while there are differences in their vascular density and distribution, both human ADPKD and pkd2(WS25/-) mouse liver cyst walls develop vascular structures as they grow out from the liver. In vitro studies demonstrate that angiogenic factors secreted by the liver cyst wall epithelium, including VEGF-A and IL-8, can drive angiogenic development of human endothelial cells. This development is blocked by inhibition of VEGF receptor signaling. Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "The article by Brodsky and colleagues provides the important insight that the liver cyst walls maintain a vasculature as they grow out from the liver and that VEGF receptor signaling plays a key role in inducing angiogenesis. These multidisciplinary studies lay a framework for the development of new therapies aimed at preventing the growth of liver cysts in patients with ADPKD".


'/>"/>

Contact: Dr. R. Brian Doctor
brian.doctor@ucdenver.edu
303-724-7224
Society for Experimental Biology and Medicine
Source:Eurekalert

Related biology news :

1. Venous origin of the mammalian lymphatic vasculature
2. Black carbon pollution emerges as major player in global warming
3. RNA emerges from DNAs shadow
4. Cataloguing invisible life: Microbe genome emerges from lake sediment
5. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
6. Neuronal conduction of excitation without action potentials based on ceramide production
7. To maximize biofuel potential, researchers look for sorghums sweet spot
8. Joslin researchers uncover potential role of leptin in diabetes
9. Chemistry turns killer gas into potential cure
10. Researchers examine worlds potential to produce biodiesel
11. New inhibitor has potential as cancer drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... ... May 25, 2017 , ... Throughout this webinar, participants will ... process development and economic goals were achieved in both industry and academic settings. ... system, along with techniques for scaling production of mesenchymal stem cells (MSCs) and ...
(Date:5/24/2017)... ... May 23, 2017 , ... ... high quality relocatable and permanent modular buildings, announced the launch of the ... modern office design characteristics to help support on-site teamwork and collaboration. , ...
(Date:5/23/2017)... , ... May 23, 2017 , ... A recent survey ... most troublesome and difficult to control weed in 12 categories of broadleaf crops, fruits ... 200 weed scientists across the U.S. and Canada participated in the 2016 survey, the ...
(Date:5/23/2017)... ... , ... Vortex Biosciences , provider of circulating tumor cell (CTC) capture ... using Vortex microfluidic technology ” in Nature Precision Oncology on May 8th. The ... and Dr. Matthew Rettig at the University of California, Los Angeles. The publication describes ...
Breaking Biology Technology: