Navigation Links
The use of placebo in rheumatoid arthritis clinical trials may negatively impact patients
Date:5/27/2011

The results of this study, conducted in Germany, re-open the debate on whether it is ethical to conduct placebo-controlled studies where patients in the placebo-group are at a serious disadvantage compared to patients taking the new treatments. The study analysed current study designs, for new therapies such as abatacept (Orencia), golimumab (Simponi) or tocilizumab (Actemra), and showed that patients in the placebo group experienced no change in medication, having to continue with their former, ineffective treatment plus placebo.

"According to the Helsinki-Declaration of the World Medical Association*, a placebo-controlled study design is deemed to be ethically acceptable when there is no other effective treatment," said Dr. Juche, Johanniter-Hospital, Treuenbrietzen, Germany. "However, this analysis confirms that patients in the placebo-group are at a disadvantage as they are given no change in medication to reduce their active inflammatory condition or halt disease progression. Our recommendation is that future clinical trials should include an active comparator group to ensure that all patients receive effective treatments to improve their quality of life."

In the analysis, researchers used studies from the European Public Assessment Report (EPAR) of the European Medicines Agency (EMA) for abatacept, golimumab and tocilizumab as samples. The studies chosen had to be placebo controlled at the beginning and state clinical relevant outcome criteria (e.g. DAS28**, ACR20***, Health Assessment Questionnaire and joint erosion scores).


'/>"/>

Contact: Rory Berrie
rory.berrie@cohnwolfe.com
44-790-151-3297
European League Against Rheumatism
Source:Eurekalert

Page: 1

Related biology news :

1. Goji berries have the same nutrients as fruits and vegetables and a placebo effect
2. New therapeutic target identified for rheumatoid arthritis
3. Anakinra for rheumatoid arthritis: A modest benefit with some risk
4. Gene therapy demonstrates benefit in patients with rheumatoid arthritis
5. Researchers identify new risk factor gene for rheumatoid arthritis
6. New trigger for chronic inflammation in rheumatoid arthritis discovered
7. BUSPH study links rheumatoid arthritis to vitamin D deficiency
8. Study confirms link between rheumatoid arthritis and COPD
9. Undertreatment of cardiovascular disease in rheumatoid arthritis patients following a heart attack
10. Geisinger research: Antimalarial drug prevents diabetes in arthritis patients
11. Inhibiting proteins may prevent cartilage breakdown in arthritis patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... 10, 2014  Data Sciences International (DSI), the ... a new series of digital telemetry implants to ... M series, part of the PhysioTel™ Digital platform, ... possible physiologic data when incorporating functional endpoints into ... to toxicology studies has evolved from short ECG ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader ... is seeing a staggering demand from its licensees for ... Company revealed, is not solely coming from fitness and ... well. "A wearable is only as useful ... accuracy is the ultimate driver in long-term mass consumer ...
(Date:12/10/2014)... 2014 CIE San Diego has launched an ... connective tissue that enhances care coordination among social service ... client-level information; earned a second $1 million grant from ... seniors aging in community and; will be recognized as ... th 4-6p. CIE San Diego today ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... Orleans, LA Research led by Ya-Ping Tang, MD, PhD, ... Sciences Center New Orleans, has found that the action of ... critical for the development of adult-onset Post-Traumatic Stress Disorder (PTSD.) ... Edition the week of April 1-5, 2013. "This is the ...
... are not yet available to build a comprehensive map of ... in the world the human brain, scientists say in ... be applied and developed for the Brain Activity Mapping (BAM) ... Human Genome Project did for genetics. Published in the ...
... the papyrus sedge for millennia. The Ancient Egyptians wrote on ... is grown for ornamentation and parts can even be eaten. ... and Management , researchers in Uganda have demonstrated that growing ... noxious residues from abattoir effluent. Robinson Odong, Frank Kansiime, ...
Cached Biology News:LSUHSC research identifies co-factors critical to PTSD development 2Brain Activity Mapping Project aims to understand the brain 2Papyrus plant detox for slaughterhouses 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... VRUS ) management will present at the Third Annual ... 2008 at the Le,Parker Meridien in New York City. ... of the company on Monday,October 6, 2008, from 10:00-10:30 ... Mr. Price,s overview via the internet, log,on to the ...
... DUBLIN, Ireland, October 1 Shire Limited,(LSE: SHP, NASDAQ: ... approval by shareholders at the Annual General,Meeting on September ... Shire,plc with effect from today., Shire plc,s ticker ... ISIN numbers of the Company,s Ordinary shares and American ...
... confirms implementation of quality systems in product ... ... function assay, COLUMBIA, Md., Oct. 1 Cylex ... The 13485:2003 certification,includes compliance with the Canadian Medical Devices ...
Cached Biology Technology:Pharmasset to Present at the JMP Securities Healthcare Focus Conference on Monday, October 6th 2Cylex(TM) Receives ISO 13485:2003 and 9001:2000 Quality Certifications 2
ABCA1 Immunogen: Mouse ABCA1-expressing HeLa stable transfectants. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Anti-rat Dipeptidyl Peptidase IV (DPP IV), CD26, Clone 5E8, Monoclonal Antibody...
JAB1 Immunogen: Synthetic peptide, conjugated to KLH, corresponding to residues S(201) E Y Q T I P L N K I E D F G V(216) of human JAB1. The sequence is identical in mouse and rat. Storage: -...
... used to detect the appearance of AcNPV ... cells as early as 8-24 hours post-infection. ... Titer Kit, which allows determination of baculovirus ... The FastPlax Antibody can also be used ...
Biology Products: