Navigation Links
The use of placebo in rheumatoid arthritis clinical trials may negatively impact patients
Date:5/27/2011

The results of this study, conducted in Germany, re-open the debate on whether it is ethical to conduct placebo-controlled studies where patients in the placebo-group are at a serious disadvantage compared to patients taking the new treatments. The study analysed current study designs, for new therapies such as abatacept (Orencia), golimumab (Simponi) or tocilizumab (Actemra), and showed that patients in the placebo group experienced no change in medication, having to continue with their former, ineffective treatment plus placebo.

"According to the Helsinki-Declaration of the World Medical Association*, a placebo-controlled study design is deemed to be ethically acceptable when there is no other effective treatment," said Dr. Juche, Johanniter-Hospital, Treuenbrietzen, Germany. "However, this analysis confirms that patients in the placebo-group are at a disadvantage as they are given no change in medication to reduce their active inflammatory condition or halt disease progression. Our recommendation is that future clinical trials should include an active comparator group to ensure that all patients receive effective treatments to improve their quality of life."

In the analysis, researchers used studies from the European Public Assessment Report (EPAR) of the European Medicines Agency (EMA) for abatacept, golimumab and tocilizumab as samples. The studies chosen had to be placebo controlled at the beginning and state clinical relevant outcome criteria (e.g. DAS28**, ACR20***, Health Assessment Questionnaire and joint erosion scores).


'/>"/>

Contact: Rory Berrie
rory.berrie@cohnwolfe.com
44-790-151-3297
European League Against Rheumatism
Source:Eurekalert

Page: 1

Related biology news :

1. Goji berries have the same nutrients as fruits and vegetables and a placebo effect
2. New therapeutic target identified for rheumatoid arthritis
3. Anakinra for rheumatoid arthritis: A modest benefit with some risk
4. Gene therapy demonstrates benefit in patients with rheumatoid arthritis
5. Researchers identify new risk factor gene for rheumatoid arthritis
6. New trigger for chronic inflammation in rheumatoid arthritis discovered
7. BUSPH study links rheumatoid arthritis to vitamin D deficiency
8. Study confirms link between rheumatoid arthritis and COPD
9. Undertreatment of cardiovascular disease in rheumatoid arthritis patients following a heart attack
10. Geisinger research: Antimalarial drug prevents diabetes in arthritis patients
11. Inhibiting proteins may prevent cartilage breakdown in arthritis patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... climatic shifts over the last 120,000 years may ... team of researchers led by City College of ... new biodiversity metric called "phylogeographic endemism." , It ... within species is restricted in geographical space. , ... 14 other researchers from institutions in Brazil, Australia ...
(Date:8/29/2014)... prolific bloomer Emiliania huxleyi , can grow without ... contradicts the common view that E. huxleyi ... of thiamine in the ocean to survive. , "It,s ... says CIFAR Senior Fellow Alexandra Worden , co-author ... fellows John Archibald (Dalhousie University), Adrin ...
(Date:8/28/2014)... app called TX Invasives is now available from the ... Texas at Austin for identifying harmful non-native plant, insect ... in the United States cause about $137 billion in ... crops, clog waterways, kill native plants and more. , ... for reporting where invasive species occur, we,re more likely ...
Breaking Biology News(10 mins):CCNY team defines new biodiversity metric 2Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Mobile app makes ID of harmful plants, insects in Texas a snap 2
... their mate with the help of smell. They prefer a ... immune system. This has been shown in a new study ... collaboration. Humans and many animals can choose a suitable ... can give the offspring an efficient immune system. This is ...
... After 16 years of planning the countdown is on for one ... a 12-man team of British scientists, engineers and support staff will ... into the heart of the frozen continent to collect samples of ... of ice. Their quest is to reveal vital secrets about ...
... studies focused on life science, drug discovery and ... The Indiana-based manufacturer of radiation detection technologies is ... of Energy,s Oak Ridge National Laboratory toward the ... researchers to study a wider variety of crystalline ...
Cached Biology News:British team set to embark on ambitious Antarctic mission to penetrate and sample ancient buried lake 2British team set to embark on ambitious Antarctic mission to penetrate and sample ancient buried lake 3ORNL's newly licensed neutron detector will advance human disease research 2
(Date:8/28/2014)... 28, 2014 SPIE Fellow Glenn Boreman, ... Optical Science and Director of the Center for Optoelectronics ... at Charlotte, and co-founder and Chairman of the Board ... the 2015 Vice President of SPIE, the international society ... Stahl announced recent election results at the Annual General ...
(Date:8/28/2014)... research platform uses a laser to measure ... stress and heating, an approach likely to ... and batteries., This new technique, called nanomechanical ... and the surface stress of microscale structures ... the merits of surface-stress influence on mechanical ...
(Date:8/28/2014)... -- Next month, executives from clinical trial marketing firm BBK Worldwide ... Patient-Centered Clinical Trials 2014 , to be held at ... September 4-5. Patient recruitment experts Bonnie A. Brescia , ... share insights on the benefits of employing an effective patient ... media to mobile apps – can be used to drive ...
(Date:8/28/2014)... Florida State University research team has led to a ... white light, and convert photon energy directly to mechanical ... , Biwu Ma, associate professor in the Department of ... Engineering, created the molecule in a lab about a ... creation has many other unique capabilities. , For example, ...
Breaking Biology Technology:Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2
... Australia, Dec. 17 Phosphagenics,Limited ("Phosphagenics") (ASX: POH, ... its Phase 1 clinical trial that showed its,delivery ... skin without causing disruption or irritation of any ... be the first company to,commercialize a sustained release ...
... MOUNTAINSIDE, N.J., Dec. 17 National Stem,Cell Holding, ... company,information, financial information, quotations and press releases are,posted ... Sheets., OTCIQ is a secure, web-based portal ... to facilitate communication with the,marketplace, promote transparency, mitigate ...
... Will Enhance Quality and Speed Image Transfer at Lower ... Cost While Ensuring 21 CFR Part 11 Compliance, ... network, today announced it has been selected by,Southwest Oncology Group ... groups in the United States, to provide a,secure, 21 CFR ...
Cached Biology Technology:Phosphagenics Announces Successful Phase 1 Transdermal Oxycodone Clinical Trial Results 2Phosphagenics Announces Successful Phase 1 Transdermal Oxycodone Clinical Trial Results 3National Stem Cell Holding, Inc. Posts Company and Financial Information on the OTCIQ and Has Retained New CFO and Counsel to File Registration Statement With SEC 2AG Mednet to Provide Image Network for Southwest Oncology Group 2
Sheep polyclonal to Malate Dehydrogenase ( Abpromise for all tested applications). Antigen: Full length protein - Pig heart malate dehydrogenase. Entrez Gene ID: 4190 Swiss Protein ID: P...
HAMP Immunogen: HAMP (AAH20612, 25 a.a. ~ 85 a.a) full length recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
... transporter 2 (APT2) (Peptide ... PSF2) (Peptide supply factor ... involved in antigen processing ... Antigen: Recombinant ...
Raised to arginine vasopressin coupled to bovine thyroglobulin with carbodiimide ....
Biology Products: