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The transmission of information via proteins could revolutionize drug discovery
Date:6/12/2014

evolves and mutates and the drug is rendered inefficient. The concept, now validated by IRB Barcelona researchers, allows one to think that the site where the drug was headed is equally as valid as any other point along the transmission pathway.

"If this were this case which is what our data show we would be able to find many sites within the structure of a protein that would be equally or more efficient at interacting with a drug. Sites that, although lying far from the key or functional site of the protein, would have the same effect," argues Salvatella.

The scientist goes on to explain that there are already many drugs that act at sites that are not the actives sites but that these drugs have been discovered by serendipity, through massive screenings of molecules and observing that they bound to an unexpected site. "This system is clearly not efficient. We have to be able to organise it and if we manage to do this, then we will have a potent way to discover new drugs," explains the researcher.

In addition to furthering the conceptual field, Salvatella is working with proteins of biomedical interest. "We already know enough to study in parallel the pathways of proteins of biomedical interest. If we are successful, we will have discovered a gold mine for drug discovery," affirms the scientist.

The first authors of the article are the postdoctoral fellows Bryn Fenwick, a former member of Xavier Salvatella's group, currently at the Scripps Research Institute of California, and Laura Orellana, a former member of Modesto Orozco's group, who is now at the Science for Life Laboratory at the Royal Institute of Technology in Stockholm. The work has been done within the joint programme in Computational Biology between BSC, CRG and IRB Barcelona.


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Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

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