Navigation Links
The sweet mysteries of the nervous system
Date:5/10/2011

The antibody 5750 recognises a specific sugar residue on the cell surface, which is called LewisX. The research group lead by Prof. Dr. Andreas Faissner has now been able to use LewisX for the first time to separate different types of stem cells. The researchers report on their results in the Journal of Biological Chemistry.

Unexpected sugar diversity

Antibodies that recognise the LewisX sugar residue are used routinely to identify so-called neural stem cells from which the various cells of the nervous system originate. Prof. Faissner's team has now shown that the designation "LewisX" does not just cover a single sugar motif, but a whole range of different sugar residues. Different types of neural stem cells are equipped with individual combinations of LewisX sugar residues on their cell surface. The new Bochum antibody 5750 recognises a different LewisX sugar residue to the antibodies previously used. "This sugar diversity could also be interesting for cancer diagnosis" Prof. Faissner explained, "because LewisX sugars have also been detected on tumour cells".

Identifying properties of stem cells

With the aid of the new antibody 5750, certain types of neural stem cells can be isolated from a mixture of different cell types. The aim of Prof. Faissner's research group is now to examine the properties of the stem cells which carry the LewisX sugar residues. The researchers have already found out that the LewisX motif on the cell surface changes when the stem cells develop further for example into oligodendrocytes, which form the insulation layer of the nerve cells, or into nerve cells themselves.


'/>"/>

Contact: Dr. Andreas Faissner
andreas.faissner@rub.de
49-234-322-3851
Ruhr-University Bochum
Source:Eurekalert  

Page: 1

Related biology news :

1. TB bacterium uses its sugar coat to sweeten its chances of living in lungs
2. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
3. Bumblebees learn the sweet smell of foraging success
4. Honey adds health benefits, is natural preservative and sweetener in salad dressings
5. Sweetened beverage consumption increases in the US
6. New standard for popular stevia-based sweetener to assure products quality
7. Spun-sugar fibers spawn sweet technique for nerve repair
8. Liking sweets makes sense for kids
9. Red pandas reveal an unexpected (artificial) sweet tooth
10. Quality and purity of popular stevia sweetener strengthened by new reference standards
11. The bitter side of sweeteners
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The sweet mysteries of the nervous system 
(Date:2/2/2017)... 1, 2017  Central to its deep commitment ... worldwide, The Japan Prize Foundation today announced the ... pushed the envelope in their respective fields of ... scientists are being recognized with the 2017 Japan ... only contribute to the advancement of science and ...
(Date:1/30/2017)...   Invitae Corporation (NYSE: NVTA ... today announced that it will report its fourth quarter ... on Monday, February 13, 2017, and Invitae,s management team ... p.m. Eastern / 1:45 p.m. Pacific. ... financial results, guidance, and recent developments and will spend ...
(Date:1/25/2017)... YORK , Jan. 25, 2017 The ... Access Management (IAM) lifecycle is comprised of a ... for the purpose of maintaining digital identities and ... resources and applications. There are significant number of ... from time to time by optimizing processes and ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... ... February 23, 2017 , ... Brain Sentinel, Inc. has received ... SPEAC® System, the Brain Sentinel® Seizure Monitoring and Alerting System. The adjunctive seizure ... periods of rest. A lightweight, non-invasive monitor is placed on the belly of ...
(Date:2/23/2017)... ... , ... The Greater Gift Initiative, Inc , (GGI) a Winston-Salem, NC ... GGI's mission is to advance global health and highlight the greater good of clinical ... each clinical trial volunteer. The vision of GGI is to serve as a philanthropic ...
(Date:2/23/2017)... ... February 22, 2017 , ... ... , have been named Fellows of the Society this year, the Fellows Committee ... the multidisciplinary fields of optics, photonics, and imaging as well as their service ...
(Date:2/22/2017)...  PrimeVax Immuno-Oncology, Inc. announced today its CEO, ... Biocom Global Life Science Partnering Conference.  The presentation will ... the Torrey Pines Lodge, in San Diego.  ... who have chosen our company, amongst numerous others, to ... and clinical researchers," said Mr. Chen. "In contrast to ...
Breaking Biology Technology: