Navigation Links
The sweet mysteries of the nervous system

The antibody 5750 recognises a specific sugar residue on the cell surface, which is called LewisX. The research group lead by Prof. Dr. Andreas Faissner has now been able to use LewisX for the first time to separate different types of stem cells. The researchers report on their results in the Journal of Biological Chemistry.

Unexpected sugar diversity

Antibodies that recognise the LewisX sugar residue are used routinely to identify so-called neural stem cells from which the various cells of the nervous system originate. Prof. Faissner's team has now shown that the designation "LewisX" does not just cover a single sugar motif, but a whole range of different sugar residues. Different types of neural stem cells are equipped with individual combinations of LewisX sugar residues on their cell surface. The new Bochum antibody 5750 recognises a different LewisX sugar residue to the antibodies previously used. "This sugar diversity could also be interesting for cancer diagnosis" Prof. Faissner explained, "because LewisX sugars have also been detected on tumour cells".

Identifying properties of stem cells

With the aid of the new antibody 5750, certain types of neural stem cells can be isolated from a mixture of different cell types. The aim of Prof. Faissner's research group is now to examine the properties of the stem cells which carry the LewisX sugar residues. The researchers have already found out that the LewisX motif on the cell surface changes when the stem cells develop further for example into oligodendrocytes, which form the insulation layer of the nerve cells, or into nerve cells themselves.


Contact: Dr. Andreas Faissner
Ruhr-University Bochum

Page: 1

Related biology news :

1. TB bacterium uses its sugar coat to sweeten its chances of living in lungs
2. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
3. Bumblebees learn the sweet smell of foraging success
4. Honey adds health benefits, is natural preservative and sweetener in salad dressings
5. Sweetened beverage consumption increases in the US
6. New standard for popular stevia-based sweetener to assure products quality
7. Spun-sugar fibers spawn sweet technique for nerve repair
8. Liking sweets makes sense for kids
9. Red pandas reveal an unexpected (artificial) sweet tooth
10. Quality and purity of popular stevia sweetener strengthened by new reference standards
11. The bitter side of sweeteners
Post Your Comments:
Related Image:
The sweet mysteries of the nervous system 
(Date:10/29/2015)... , Oct. 29, 2015  The J. Craig ... report titled, "DNA Synthesis and Biosecurity: Lessons Learned and ... Department of Health and Human Services guidance for synthetic ... 2010. --> --> ... also has the potential to pose unique biosecurity threats. ...
(Date:10/29/2015)... OXFORD, Connecticut , October 29, 2015 /PRNewswire/ ... "Company"), a biometric authentication company focused on the ... Wocket® smart wallet announces that StackCommerce, a leading ... will be featuring the Wocket® smart wallet on ... NXTD ) ("NXT-ID" or the "Company"), a ...
(Date:10/27/2015)... Oct. 27, 2015 Synaptics Inc. (NASDAQ: SYNA ... that Google has adopted the Synaptics ® ClearPad ... to power its newest flagship smartphones, the Nexus 5X ... --> --> Synaptics ... provide strategic collaboration in the joint development of next ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... ... November 27, 2015 , ... Pittcon is pleased to ... presentations offered in symposia, oral sessions, workshops, awards, and posters. The core ... of applications such as, but not limited to, biotechnology, biomedical, drug discovery, environmental, ...
(Date:11/26/2015)... CHESHAM , England , November 26, ... Lightpoint Medical, an innovative medical device company specializing in ... Euro grant from the European Commission as part of the ... enabling the company to carry out a large-scale clinical trial ... -->      (Logo: , ...
(Date:11/25/2015)... 2015 2 nouvelles études permettent d ... les différences entre les souches bactériennes retrouvées dans la plaque ... êtres humains . Ces recherches  ouvrent une nouvelle ... en charge efficace de l,un des problèmes de ... .    --> 2 nouvelles études permettent ...
(Date:11/25/2015)... 2015  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) ... CEO of Neurocrine Biosciences, will be presenting at the ... New York . .   ... 5 minutes prior to the presentation to download or ... will be available on the website approximately one hour ...
Breaking Biology Technology: