Navigation Links
The sweet mysteries of the nervous system
Date:5/10/2011

The antibody 5750 recognises a specific sugar residue on the cell surface, which is called LewisX. The research group lead by Prof. Dr. Andreas Faissner has now been able to use LewisX for the first time to separate different types of stem cells. The researchers report on their results in the Journal of Biological Chemistry.

Unexpected sugar diversity

Antibodies that recognise the LewisX sugar residue are used routinely to identify so-called neural stem cells from which the various cells of the nervous system originate. Prof. Faissner's team has now shown that the designation "LewisX" does not just cover a single sugar motif, but a whole range of different sugar residues. Different types of neural stem cells are equipped with individual combinations of LewisX sugar residues on their cell surface. The new Bochum antibody 5750 recognises a different LewisX sugar residue to the antibodies previously used. "This sugar diversity could also be interesting for cancer diagnosis" Prof. Faissner explained, "because LewisX sugars have also been detected on tumour cells".

Identifying properties of stem cells

With the aid of the new antibody 5750, certain types of neural stem cells can be isolated from a mixture of different cell types. The aim of Prof. Faissner's research group is now to examine the properties of the stem cells which carry the LewisX sugar residues. The researchers have already found out that the LewisX motif on the cell surface changes when the stem cells develop further for example into oligodendrocytes, which form the insulation layer of the nerve cells, or into nerve cells themselves.


'/>"/>

Contact: Dr. Andreas Faissner
andreas.faissner@rub.de
49-234-322-3851
Ruhr-University Bochum
Source:Eurekalert  

Page: 1

Related biology news :

1. TB bacterium uses its sugar coat to sweeten its chances of living in lungs
2. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
3. Bumblebees learn the sweet smell of foraging success
4. Honey adds health benefits, is natural preservative and sweetener in salad dressings
5. Sweetened beverage consumption increases in the US
6. New standard for popular stevia-based sweetener to assure products quality
7. Spun-sugar fibers spawn sweet technique for nerve repair
8. Liking sweets makes sense for kids
9. Red pandas reveal an unexpected (artificial) sweet tooth
10. Quality and purity of popular stevia sweetener strengthened by new reference standards
11. The bitter side of sweeteners
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The sweet mysteries of the nervous system 
(Date:2/26/2017)... -- Securus Technologies, a leading provider of civil and ... corrections and monitoring, announces the appointment of a ... often, too many offenders return to jail or ... to tackle this ongoing problem and improve the ... significant steps are underway, Securus continues to invest ...
(Date:2/22/2017)... 2017 With the biometrics market to ... four technologies that innovative and agile startups must ... in the changing competitive landscape: multifactor authentication (MFA), ... "Companies can no longer afford to ... Dimitrios Pavlakis , Industry Analyst at ABI ...
(Date:2/21/2017)... LONDON , February 21, 2017 ... um 70 Millionen US-Dollar wachsen. Nach einem Gespräch mit mehr ... es einige Hindernisse zu überwinden gilt, um diese Prognose ... ... unter anderem die Mobilisierung der finanziellen Mittel für die ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... LEXINGTON, Mass. , March 24, 2017 ... pipeline of immune checkpoint antibodies and cancer vaccines, today ... The 7 th  Annual William Blair and Maidstone ... Event Space Alexandria Center in New York, ... March 29 at 9:40 am: ...
(Date:3/23/2017)...  Northwest Biotherapeutics (OTCQB: NWBO) (NW Bio), a ... solid tumor cancers, today announced that yesterday it ... last Friday, March 17, 2017. ... totaling 28,843,692 shares, comprised of 18,843,692 common shares ... Class C Warrants pre-funded at the closing at ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... recently selected by the Connecticut Technology Council (CTC) as a 2017 Women of ... thirteenth annual Women of Innovation Awards Dinner. , The dinner recognizes women accomplished ...
(Date:3/23/2017)... Colo. , March 23, 2017  Agriculture technology ... Series A financing and note conversion to commercialize its ... Planet is focused on developing products that are simultaneously ... $30 million in the last 18 months. This latest ... North Bridge Venture Partners. The company,s ...
Breaking Biology Technology: