Navigation Links
The sound of light: Innovative technology shatters the barriers of modern light microscopy
Date:6/30/2009

In the past, even modern technologies have failed to produce high-resolution fluorescence images from this depth because of the strong scattering of light. In the Nature Photonics journal, the Munich researchers describe how they can reveal genetic expression within live fly larvae and fish by "listening to light". In the future this technology may facilitate the examination of tumors or coronary vessels in humans.

Since the dawn of the microscope scientists have been using light to scrutinize thin sections of tissue to ascertain whether they are healthy or diseased or to investigate cell function. However, the penetration limits for this kind of examination lie between half a millimeter and one millimeter of tissue. In thicker layers light is diffused so strongly that all useful details are obscured.

Together with his research team, Professor Vasilis Ntziachristos, director of the Institute of Biological and Medical Imaging of the Helmholtz Zentrum Mnchen German Research Center for Environmental Health and chair for biological imaging at the Technische Universitt Mnchen, has now broken through this barrier and rendered three-dimensional images through at least six millimeters of tissue, allowing whole-body visualization of adult zebra fish.

To achieve this feat, Prof. Ntziachristos and his team made light audible. They illuminated the fish from multiple angles using flashes of laser light that are absorbed by fluorescent pigments in the tissue of the genetically modified fish. The fluorescent pigments absorb the light, a process that causes slight local increases temperature, which in turn result in tiny local volume expansions. This happens very quickly and creates small shock waves. In effect, the short laser pulse gives rise to an ultrasound wave that the researchers pick up with an ultrasound microphone.

The real power of the technique, however, lies in specially developed mathematical formulas used to analyze t
'/>"/>

Contact: Sven Winkler
presse@helmholtz-muenchen.de
0049-893-187-3946
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. 1 person out of every 1,000 has synaesthesia, in which an individual can smell a sound
2. The art of using science to inform ecosystem restoration in Puget Sound
3. Deep-sea sharks wired for sound
4. New 3-D ultrasound could improve stroke diagnosis, care
5. Sounding out heart problems automatically
6. If a street tree falls... what does it take to make sound policy?
7. Anti-tumor therapy with endoscopic ultrasound may fight cancer more safely and effectively
8. Bats pick up rustling sounds against highway background noise
9. Alternative to burning: environmentally sound disposal for wood chips
10. Effects of anthropogenic sound on marine mammals -- a research strategy
11. Floridas worm grunters collect bait worms by inadvertently imitating mole sounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... CORAL SPRINGS, Florida , July 1, 2014 ... smart wallets pave way for convenience and improved security: NXT-ID, ... Google Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ... ) and MasterCard Corporation (NYSE: MA) NXT-ID, Inc., (OTCQB: ... market, is pleased to announce that the second series of ...
(Date:7/10/2014)... 2, 2014 It is a great honor ... appointment of the world-renowned Thoracic and Cardiovascular surgeon, Mark ... Dr. Ginsburg, with over 34 years of experience, ... and Good Samaritan Regional Medical Center. Dr. Ginsburg has ... 1980,s and is considered an expert in the implantation ...
(Date:7/10/2014)... According to the new market research report, ... (Optical Prism, Pizeoelectric, Capacitive, and Adhesives), Application (Mobile Devices, ... and Geography - Global Trends & Forecasts to 2014 ... Market is projected to cross $14.35 Billion by 2020, ... to 2020. Browse more than 78 market ...
Breaking Biology News(10 mins):Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3
... Aug. 28 Gamma globulin, a type of antibody ... given to health care workers and international travelers to ... treatment for pinkeye with little apparent toxicity, according to ... School of Medicine. The results of the study, being ...
... prevalent cancers in the Western world. The tumor starts off ... violent cancer, which often spreads to the liver. In an ... Ben-Zeev and Dr. Nancy Gavert of the Weizmann Institutes Molecular ... In a majority of cases, colorectal cancer is initiated ...
... of Pennsylvania researchers have designed a nanoscale system ... to external forces. By combining microfabricated ... nanoscale sensors, the study showed that cells respond ... relationship between cells and their environment. The study ...
Cached Biology News:Gamma globulin effective in treating eye infections caused by adenoviruses 2A gene for metastasis 2Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces 2
(Date:7/11/2014)... , July 11, 2014  Researchers have pioneered ... images. The new technology, called Virtual Finger, allows ... structures like neurons and synapses using the flat ... technology makes 3D imaging studies orders of magnitude ... an unprecedented level across many areas of experimental ...
(Date:7/10/2014)... July 10, 2014 Understanding the need ... cell lines, and the gap that currently exists in ... expand its industry-leading portfolio of validated ion channel and ... channel-expressing cell lines, as ion channels control many critical ... this activity creates the potential to treat a variety ...
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has been upgraded for ... a second treatment cup to help prevent and smooth skin ... thinner on the edges for a softer contact with the ... surfaces on the face, neck and décolleté. Choose to use ... such as the cheeks and neck, or opt for the ...
(Date:7/10/2014)... , July 10, 2014 /PRNewswire-iReach/ -- ... and interpretation, today announced an agreement with ... analytics for Lineagen,s NextStep Dx PLUS.  ... neurodevelopmental and neurological disorders, currently offers FirstStep ... (CMA) testing service used by healthcare providers ...
Breaking Biology Technology:Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... Assembly Speaker Mike Huebsch , R-West Salem, and State ... to serve on the Speaker's Task Force on Information Technology ... a number of failed information technology projects in state government, ... sectors. , ,In addition to Montgomery, who will serve as ...
... we will often hear, Oh, about 11,000 hours. , ... another 11,000-hour project that was canceled without producing any software? ... bitof software, but software that was extremely profitable? There's an ... of software, we're left with hand waving. , ,Hand waving ...
... 10th in a series of articles on developing start-up companies ... Madison, Wis. - In Step 9 we discussed ... specifically on the federal laws. , ,Any business that ... federal securities laws and regulations. Of equal importance are the ...
Cached Biology Technology:Eight lawmakers named to Speaker's IT task force 2Defining the X-factor: What is an ounce of software worth? 2Defining the X-factor: What is an ounce of software worth? 3Defining the X-factor: What is an ounce of software worth? 4Early Stage 10: The nuances of federal laws 2Early Stage 10: The nuances of federal laws 3Early Stage 10: The nuances of federal laws 4Early Stage 10: The nuances of federal laws 5
SHEEP ANTI DEHYDROEPIANDROSTERONE...
MOUSE ANTI POLY (ADP-RIBOSE) Immunogen: Purified poly (ADP-ribose) polymer, 10-50 unit chain length...
This issue concentrated on the purification of proteins for specific purposes (i.e. large-scale purification, purification for therapeutic use, etc.)...
... (1997) • Contains short but ... & molecular biology, arranged under ... give details of biochemical substances ... they are involved and define ...
Biology Products: