Navigation Links
The sound of light: Innovative technology shatters the barriers of modern light microscopy
Date:6/30/2009

In the past, even modern technologies have failed to produce high-resolution fluorescence images from this depth because of the strong scattering of light. In the Nature Photonics journal, the Munich researchers describe how they can reveal genetic expression within live fly larvae and fish by "listening to light". In the future this technology may facilitate the examination of tumors or coronary vessels in humans.

Since the dawn of the microscope scientists have been using light to scrutinize thin sections of tissue to ascertain whether they are healthy or diseased or to investigate cell function. However, the penetration limits for this kind of examination lie between half a millimeter and one millimeter of tissue. In thicker layers light is diffused so strongly that all useful details are obscured.

Together with his research team, Professor Vasilis Ntziachristos, director of the Institute of Biological and Medical Imaging of the Helmholtz Zentrum Mnchen German Research Center for Environmental Health and chair for biological imaging at the Technische Universitt Mnchen, has now broken through this barrier and rendered three-dimensional images through at least six millimeters of tissue, allowing whole-body visualization of adult zebra fish.

To achieve this feat, Prof. Ntziachristos and his team made light audible. They illuminated the fish from multiple angles using flashes of laser light that are absorbed by fluorescent pigments in the tissue of the genetically modified fish. The fluorescent pigments absorb the light, a process that causes slight local increases temperature, which in turn result in tiny local volume expansions. This happens very quickly and creates small shock waves. In effect, the short laser pulse gives rise to an ultrasound wave that the researchers pick up with an ultrasound microphone.

The real power of the technique, however, lies in specially developed mathematical formulas used to analyze t
'/>"/>

Contact: Sven Winkler
presse@helmholtz-muenchen.de
0049-893-187-3946
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. 1 person out of every 1,000 has synaesthesia, in which an individual can smell a sound
2. The art of using science to inform ecosystem restoration in Puget Sound
3. Deep-sea sharks wired for sound
4. New 3-D ultrasound could improve stroke diagnosis, care
5. Sounding out heart problems automatically
6. If a street tree falls... what does it take to make sound policy?
7. Anti-tumor therapy with endoscopic ultrasound may fight cancer more safely and effectively
8. Bats pick up rustling sounds against highway background noise
9. Alternative to burning: environmentally sound disposal for wood chips
10. Effects of anthropogenic sound on marine mammals -- a research strategy
11. Floridas worm grunters collect bait worms by inadvertently imitating mole sounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2014)... GARDENS, Fla. , Dec. 3, 2014 /PRNewswire/ ... solutions, today announced that its DigitalPersona ® ... fingerprint readers have been deployed throughout First Bank ... , South Carolina and ... in Southern Pines, North Carolina ...
(Date:11/21/2014)... , November 18, 2014 ... Systems Market by Systems (Video, RFID, Access Control, Intrusion ... Factories, Hotels, Banks, Government), Component Service Geography - Global ... Systems Market is projected to be around $25 Billion ... by 2020, growing at a CAGR of 8.69%. ...
(Date:11/21/2014)... C-Labs LLC, a leading provider of remote ... today announced the appointment of John Traynor ... strategic advisor to the firm, Mr. Traynor will now ... based out of the C-Labs office in ... Muench , Chief Executive Officer. Photo - ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... development of the mammalian brain, the cerebral cortex undergoes ... which is accommodated by folding of the tissue in ... Researchers have now identified a key regulator of this ... are devoted to the performance of specific tasks. This ...
... has won a grant from the Melanoma Research Alliance ... for patients with the disease., Navin Varadarajan, an assistant ... Rahr-MRA Young Investigator Award. The grant gives him $225,000 ... helped melanoma patients who aren,t responding to any other ...
... Amsterdam, The Netherlands, Friday 26 April 2013: New data ... Liver Congress 2013 demonstrate substantial improvements in the detection ... diagnostic urine tests. HCC is common throughout the ... of chronic viral hepatitis or cirrhosis of any cause. ...
Cached Biology News:Developmental neurobiology: How the brain folds to fit 2University of Houston engineering professor awarded grant to study melanoma treatment 2University of Houston engineering professor awarded grant to study melanoma treatment 3Novel screening tests for liver cancer 2Novel screening tests for liver cancer 3
(Date:12/24/2014)... Dec. 23, 2014 Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today that investors including Oracle ... Fund LLC and several Vermillion directors have agreed ... of Vermillion,s common stock and warrants to purchase ... private placement.  Under the terms ...
(Date:12/22/2014)... & Brussels (PRWEB) December 22, 2014 ... (CfPIE), the global leader of technical training across the ... for Clinical Data Management (SCDM) to provide the ... certification programs —providing access to the more than ... extends SCDM members with 10% off when registering for ...
(Date:12/22/2014)... Calif. , Dec. 22, 2014  ( www.competitivehealth.com ... CoPatient, an online medical bill review and advocacy service, ... in the FREE WellCard Savings discount health services marketplace. ... bill that was more than they expected to pay. ... reduce health care costs, WellCard Savings is pleased to ...
(Date:12/19/2014)... Charm Sciences is pleased to announce that its ... M1 in raw commingled milk is the first lateral ... peer reviewed report of the validation by Technology and ... Fisheries Research (ILVO-T&V) has been published by the Taylor ... toxic aflatoxin and a known carcinogen, can be passed ...
Breaking Biology Technology:Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2
... breakthrough on Alzheimer's disease, UW-Madison researcher Jeff Johnson has ... drug. , ,Johnson and fellow researcher Thor Stein led ... asking a simple question: Why don't mouse neurons die ... kill human neurons in early onset Alzheimer's patients? From ...
... business attire these days, it seems hard to imagine that ... , ,(In the spirit of full disclosure, I have to ... other way while a software engineering manager at Digital ... of a construction crew working at our building.) , ,If ...
... and gone, the University of Wisconsin-Madison still has ... Fluffy Bunnies , a team of three computer programming students ... 3 to 7 to compete in the world finals of ... . The team entered the finals by taking first place ...
Cached Biology Technology:Madison-based Mithridion seeks to capitalize on Alzheimer's breakthrough 2Madison-based Mithridion seeks to capitalize on Alzheimer's breakthrough 3Madison-based Mithridion seeks to capitalize on Alzheimer's breakthrough 4Dressing information technology in business clothes 2Dressing information technology in business clothes 3'Fluffy Bunnies' ready for Shanghai programming competition 2'Fluffy Bunnies' ready for Shanghai programming competition 3
Goat polyclonal to Centaurin alpha 2**...
Mouse Anti-Human Killer Cell Immunoglobulin-like Receptor, Two Domains, Long Cytoplasmic Tail, 2 (KIR2DL2 (KIR2DL3 Monoclonal Antibody Family: Immunoglobulin Sub-Family: not assigned-Immunogl...
MagSi monodispers, magnetic silica particles with modified surface for SO3 coupling chemistry....
Recognizes a full-length CLC-2 voltage-gated Cl- protein and not with other known proteins tested so far....
Biology Products: