Navigation Links
The smell of danger
Date:6/28/2011

e able to detect?

In Liberles's lab at Harvard Medical School, graduate student David Ferrero began a search for other natural compounds that were detected by the TAARs. Working with commercially available predator and prey urine (used by gardeners to keep pests out of their crops and by hunters to mask their own scent or as lures for prey), Ferrero discovered that one of the 14 TAARs, TAAR4, detected the odor of several carnivores.

It seemed they had found a kairomone, a chemical that works like a pheromone, except that it communicates between members of different species instead of members of the same species. Prior to this discovery, the only known rodent-carnivore kairomones were a volatile compound produced by foxes, but not in that of other predators, and two non-volatile compounds produced by cats and rats (which prey on mice). Volatile compounds aerosolize and can be smelled at great distances; non-volatile compounds need to be sniffed more directly, something that would not be helpful in avoiding a predator directly but rather their terrain.

"One of the things that's really new here is that this is a generalized predator kairomone that's volatile," said Ferrero.

For rodents, it's the smell of danger.

Ferrero identified the compound that activates TAAR4 as 2-phenylethylamine, a product of protein metabolism. He then obtained specimens from 38 species of mammals and found elevated levels of 2-phenylethylamineby 18 of 19 species of carnivores, but not by non-carnivores (including rabbits, deer, primates, and a giraffe).

"It's been known so long that predator odors are great rodent deterrents, but we've discovered one molecule that's a key part of this ecological relationship," Ferrero said.

In a series of behavior tests, rats and mice showed a clear, innate avoidance to the smell of 2-phenylethylamine. The behavioral studies were repeated using a carnivore samples that had been depleted of 2-pheny
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Clubbers can smell a good nightspot
2. Smell and taste experts at international conference -- April 13-17, 2011
3. Researchers unlock new secret to how smells are detected
4. The brain knows what the nose smells, but how? Stanford researchers trace the answer
5. Study shows pregnant mothers diet impacts infants sense of smell
6. Mice that smell light could help us better understand olfaction
7. New findings on taste and smell
8. Could smell play a role in the origin of new bird species?
9. Smelling the scenery in stereo
10. Monell Center joins with CAS to host Beijing meeting on taste and smell research
11. How the 100th protein structure solved at Diamond impacts our understanding of how insects smell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... Nov. 17, 2014   News ... collaborate to develop The Partners Data Lake, an ... Partners Data Lake will allow researcher and clinicians ... treatment and the lives of patients , ... clinical activities across the Partners system, breaking down ...
(Date:11/11/2014)... 2014  Forensicon, Inc., a Chicago ... announce the promotion of Yaniv Schiff from ... In Schiff,s new role as Director, he will lead ... forensics examiners and provide leadership within the company,s digital ... http://photos.prnewswire.com/prnh/20141110/157719 Schiff joined Forensicon in ...
(Date:11/6/2014)... Fla. -- A groundbreaking paper from a team of ... understanding of how plants could adapt to and survive ... research, published in the latest issue of the journal ... chromatin (the complex of DNA and proteins) is organized ... so that some genes are turned on and others ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Maize analysis yields whole new world of genetic science 2
... homeowners out in their yards, busily attempting to control ... weed-free lawns. Dandelions, broadleaf perennial plants that have a ... most patient gardener reach for chemical weed killers to ... answer to an environmentally responsible way to control dandelions ...
... Researchers in Australia are developing diversionary tactics to fool ... responsible for major gut infections, such as cholera, produce ... complex sugar receptors displayed on the surface of cells ... for General Microbiology,s meeting at Heriot-Watt University, Edinburgh, today ...
... A study that tracked genetic mutations through the human equivalent ... that oxidative DNA damage is a primary cause of the ... a leading cause of aging, cancer and other diseases. ... Academy of Sciences , also indicated that natural selection is ...
Cached Biology News:Organic weed control for dandelions 2Designing probiotics that ambush gut pathogens 2Study of huge numbers of genetic mutations point to oxidative stress as underlying cause 2Study of huge numbers of genetic mutations point to oxidative stress as underlying cause 3
(Date:11/27/2014)... 27, 2014 First articles ... Elsevier , a world-leading provider of ... pleased to announce the launch of a new journal: ... The launch of Extreme Mechanics Letters ... the forefront of applied sciences such as micro and ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 2014 ... is a professional and in-depth research report on ... information, like its definition, classification, application, and industry ... report covers the international market analysis, including China’s ... the US, Europe, Asia, China, Japan etc. regions) ...
(Date:11/26/2014)... , Nov. 26, 2014 The ... from a survey of European physicians at the ... Innovation and Biological Therapies" at the Spanish Ministry ... hosted by EuropaBio and the Spanish Bioindustry Association ... Health, physicians from Spanish oncology and rheumatology societies, ...
(Date:11/26/2014)... 2014 SonaCare Medical, a leading ... devices, recently participated in the American Urology Association’s ... .” Key opinion leaders in urology presented on ... small renal masses while attendees had the opportunity ... in hands-on labs. Attendees at the Los Angeles, ...
Breaking Biology Technology:Elsevier Announces the Launch of a New Journal: Extreme Mechanics Letters 2Elsevier Announces the Launch of a New Journal: Extreme Mechanics Letters 3Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 2Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 3ASBM Presents European Physicians Survey at Spanish Ministry of Health 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3
... Nov. 3 /PRNewswire-FirstCall/ - AEterna Zentaris Inc.,(NASDAQ: ... focused on,endocrine therapy and oncology, today reported that ... for its Phase 2 trial in endometrial,cancer with ... doxorubicin. The decision to enter the second stage ...
... Nov. 3 Portola,Pharmaceuticals, a biopharmaceutical company ... cardiovascular and inflammatory,diseases, and cancer, today announced ... large Phase II clinical trial of betrixaban, ... for stroke prevention in patients with,atrial fibrillation ...
... placebo controlled Phase 2, clinical trial indicate statistically significant reduction in ... ... CDAD, PRINCETON, N.J. and JAMAICA PLAIN, Mass., Nov. 3 /PRNewswire-FirstCall/,-- ... of the University of Massachusetts Medical School (UMMS) today,announced that a ...
Cached Biology Technology:AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Endometrial Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108 2AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Endometrial Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108 3AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Endometrial Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108 4AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Endometrial Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108 5Portola Pharmaceuticals Initiates Phase II Trial of Betrixaban, its Novel Oral Factor Xa Inhibitor for Stroke Prevention in Atrial Fibrillation 2Portola Pharmaceuticals Initiates Phase II Trial of Betrixaban, its Novel Oral Factor Xa Inhibitor for Stroke Prevention in Atrial Fibrillation 3Portola Pharmaceuticals Initiates Phase II Trial of Betrixaban, its Novel Oral Factor Xa Inhibitor for Stroke Prevention in Atrial Fibrillation 4Medarex and Massachusetts Biologic Laboratories Announce Primary Objective Achieved in Phase 2 Trial of Monoclonal Antibody Combination for the Treatment of Clostridium difficile Associated Diarrhea (CDAD) 2Medarex and Massachusetts Biologic Laboratories Announce Primary Objective Achieved in Phase 2 Trial of Monoclonal Antibody Combination for the Treatment of Clostridium difficile Associated Diarrhea (CDAD) 3Medarex and Massachusetts Biologic Laboratories Announce Primary Objective Achieved in Phase 2 Trial of Monoclonal Antibody Combination for the Treatment of Clostridium difficile Associated Diarrhea (CDAD) 4Medarex and Massachusetts Biologic Laboratories Announce Primary Objective Achieved in Phase 2 Trial of Monoclonal Antibody Combination for the Treatment of Clostridium difficile Associated Diarrhea (CDAD) 5Medarex and Massachusetts Biologic Laboratories Announce Primary Objective Achieved in Phase 2 Trial of Monoclonal Antibody Combination for the Treatment of Clostridium difficile Associated Diarrhea (CDAD) 6
... Agencourt offers SNP loci identification ... includes automated assay design, intensive assay ... sequencing of Corriell or customer-supplied samples ... Discovery service provides for rapid and ...
... delivers enhanced statistics and statistical interpretation ... improvement managers. As an accepted organizational ... simplifies statistics for novice users and ... experts. It offers a powerful JMP ...
... Microarray plates are ideal for use as source ... handling applications (down to 5µl). These plates are ... design. Features 384 round ... 70µl well volume (cylindrical well), 55µl well ...
... formulated for mounting tissue specimens, cell smears, ... immunohistochemical methods for viewing by light microscopy. ... such as AEC, that are alcohol-soluble or ... when slides are cover-slipped forming a coating ...
Biology Products: