Navigation Links
The smell of danger
Date:6/28/2011

The mechanics of instinctive behavior are mysterious. Even something as simple as the question of how a mouse can use its powerful sense of smell to detect and evade predators, including species it has never met before, has been almost totally unknown at the molecular level until now.

David Ferrero and Stephen Liberles, neuroscientists at Harvard Medical School, have discovered a single compound found in high concentrations in the urine of carnivores that triggers an instinctual avoidance response in mice and rats. This is the first time that scientists have identified a chemical tag that would let rodents sense carnivores in general from a safe distance. The authors write that understanding the molecular basis of predator odor recognition by rodents will provide crucial tools to study the neural circuitry associated with innate behavior.

Their findings were published online in the Proceedings of the National Academy of Sciences on June 20, 2011.

The search began in 2006, when Stephen Liberles, now Assistant Professor of Cell Biology at Harvard Medical School, was working as a post-doc in the lab of Linda Buck. Buck was part of the team that won the Nobel Prize for identifying the receptors that allow olfactory neurons to detect odors. While in her lab, Liberles identified a new type of olfactory receptor, the trace amine-associated receptors (TAARs).

Mice have about 1200 kinds of odor receptors, and 14 kinds of TAARs. In comparison, humans who rely more on vision than smell have about 350 odor receptors and five TAARs.

Liberles's initial findings indicated that several of the TAARs detect chemicals found in mouse urine, including a chemical with enriched production by males. He wondered, could TAARs (which appear to have originally evolved from neurotransmitter receptors that mediate behavior and emotion) play a role in the social behavior of rodents? What other kinds of naturally occurring odors might they b
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Clubbers can smell a good nightspot
2. Smell and taste experts at international conference -- April 13-17, 2011
3. Researchers unlock new secret to how smells are detected
4. The brain knows what the nose smells, but how? Stanford researchers trace the answer
5. Study shows pregnant mothers diet impacts infants sense of smell
6. Mice that smell light could help us better understand olfaction
7. New findings on taste and smell
8. Could smell play a role in the origin of new bird species?
9. Smelling the scenery in stereo
10. Monell Center joins with CAS to host Beijing meeting on taste and smell research
11. How the 100th protein structure solved at Diamond impacts our understanding of how insects smell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... Curemark LLC, a privately held drug research ... Phase III double blind, randomized, placebo-controlled clinical trial to ... all children ages 3-8 with Autism. Previously, Curemark announced ... blinded clinical trial for CM-AT in children ages 3-8 ... enzyme chymotrypsin. This new trial will help determine whether ...
(Date:5/6/2015)... TEL AVIV, Israel , May 6, 2015 /PRNewswire/ ... the world,s most established helmet producer, announced today that ... LifeBEAM Smart Helmet, the world,s first bio-sensing cycling helmet ... will be released in two new colors in order ... demand for the product. In addition, LifeBEAM and Lazer ...
(Date:4/27/2015)... Profile Solutions, Inc. (OTC: PSIQ), a leading ... pleased to announce that Dr Gerry Bedore ... of its scientific advisory board. ... leader in technology-enhanced learning models. He was a co-founder ... studies and books focused on online student success and ...
Breaking Biology News(10 mins):Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... of marine biologists has found that existing diversity in ... extreme temperature disturbances such as those predicted from ... on the species of algae living within corals may ... temperatures changes. The results will be published online in ...
... altitude medicine is a "natural research laboratory" for the ... can shed light on conditions and diseases that mimic ... top of mountains. Yves Allemann, MD, FESC, Swiss Cardiovascular ... Hospitalier Universitaire Vaudois, Lausanne, have assembled an international group ...
... Scientists at the University of Kentucky Markey Cancer Center ... enables tumor cells to spread to adjacent or distant parts ... opens the way to new lines of research aimed at ... by Peter Zhou, associate professor of molecular and cellular biochemistry ...
Cached Biology News:New study sheds light on corals' susceptibility to temperature change 2High-altitude research advances low-altitude medicine 2High-altitude research advances low-altitude medicine 3Key mechanism identified in metastatic breast cancer 2
(Date:5/21/2015)... As part of its philanthropic partnership ... Health Foundation funded a $3.25 million project to relocate ... the most up-to-date features and technology. , The new ... 45 staff members will begin moving from the current ... coming days. , The current pharmacy has been ...
(Date:5/21/2015)... Ontario (PRWEB) May 21, 2015 ... into an exclusive North American distribution agreement with ... testing system. , With more than 160 years ... products and services for laboratory and production facilities, ... operational excellence and differentiated services to enable science. ...
(Date:5/20/2015)... , May 20, 2015 Research and Markets ... of the "Top Technologies in HW_Technical Insights" ... of this report evaluated technology trends in the Health ... that are likely to have an impact in the ... analysis of the top 10 health and wellness technologies ...
(Date:5/20/2015)... 20, 2015  Select Medical Corporation ("Select") (NYSE: ... Commission granted early termination of the waiting period ... 1976, as amended, applicable to the acquisition of ... joint venture that Select has created with Welsh, ... previously announced, MJ Acquisition Corporation has signed a ...
Breaking Biology Technology:Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 3Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Top Technologies in the Health and Wellness Industry 2015 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2
... 12 Raptor Pharmaceuticals Corp.,(OTC Bulletin Board: RPTP), today ... clinical development subsidiary, will,present at the 2008 BIO International ... Diego Convention Center in San Diego, CA., Mr. ... 18, 2008 at 1:15p.m. (PT) in room 4 of ...
... MTA: CTIC) today announced that a single institutional investor,has ... Convertible,Senior Notes due 2011, with an initial conversion price ... 14.6 million shares of common stock,with an exercise price ... partial exercise of a previously granted,warrant right for the ...
... Organization Takes Prominent Position and ... WEST SENECA, N.Y., June 11 Palladian Muscular ... to,create a high-profile presence at a leading healthcare event ... Wednesday, June,18 to Friday, June 20, 2008., "We ...
Cached Biology Technology:Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention 2Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention 3Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention 4Cell Therapeutics, Inc. Announces Issuance of 2011 Convertible Senior Notes and Common Stock Warrants to a Single Institutional Investor 2Palladian Muscular Skeletal Health (formerly Prism Health Networks) to Promote Collaborative, Expanded Practice Model at Major Insurance Conference in June 2
... as an internal standard for the quantification ... spectrometry. 5-OxoETE is a polyunsaturated keto acid ... human neutrophils. It stimulates cytosolic calcium levels ... nM. 5-OxoETE selectively stimulates the migration and ...
... dsRNA Marker consists of ten double-stranded RNAs, ... 400, 500 and 1,000 base pairs. The ... for determinating sizes of double-stranded RNAs. A ... dsRNA Marker is adjusted to approximately 25 ...
... off-white solid. A nucleoside antibiotic that ... formation of N-glycosidic protein-carbohydrate linkages. Active ... bacteria, yeasts, fungi, and viruses. Inhibits ... on human T-lymphoblastoid cells. Also inhibits ...
... of enzymes involved in matrix degradation. Of ... ten exist in soluble form whereas MT-MMPs ... MT3-MMP also known as MMP14, MMP15, MMP16 ... them to the cell surface. They have ...
Biology Products: