Navigation Links
The secrets of a tadpole's tail and the implications for human healing
Date:1/13/2013

ised to find these high levels of ROS during tail regeneration. Traditionally, ROS have been thought to have a negative impact on cells. But in this case they seemed to be having a positive impact on tail re-growth."

To assess how vital the presence of ROS are in the regeneration process, Professor Amaya's team limited ROS production using two methods. The first was by using chemicals, including an antioxidant, and the second was by removing a gene responsible for ROS production. In both cases the regeneration process was inhibited and the tadpole tail did not grow back.

Professor Amaya says: "When we decreased ROS levels, tissue growth and regeneration failed to occur. Our research suggests that ROS are essential to initiate and sustain the regeneration response. We also found that ROS production is essential to activate Wnt signalling, which has been implicated in essentially every studied regeneration system, including those found in humans. It was also striking that our study showed that antioxidants had such a negative impact on tissue regrowth, as we are often told that antioxidants should be beneficial to health."

The publication of Professor Amaya's study comes just days after a paper from the Nobel Prize winner and co-discoverer of the structure of DNA, James Watson, who has suggested antioxidants could be harmful to people in the later stages of cancer.

Professor Amaya comments: "It's very interesting that two papers suggesting that antioxidants may not always be beneficial have been published recently. Our findings and those of others are leading to a reversal in our thinking about the relative beneficial versus harmful effects that oxidants and antioxidants may have on human health, and indeed that oxidants, such as ROS, may play some important beneficial roles in healing and regeneration."

The next step for the team at the Healing Foundation Centre will be to study ROS and their role in the healing and regenerat
'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Secrets of gentle touch revealed
2. Biologists unlocking the secrets of plant defenses, 1 piece at a time
3. Pond skating insects reveal water-walking secrets
4. Biophysicists unravel secrets of genetic switch
5. Ancient genome reveals its secrets
6. New model gives hands-on help for learning the secrets of molecules
7. Decoding the secrets of balance
8. Hidden secrets in the worlds most northerly rainforests
9. Large, medically important class of proteins starts to yield its secrets
10. Rensselaer scientists unlock some key secrets of photosynthesis
11. Track Atlantic bluefin tuna to learn migration, habitat secrets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... has its own microbial terroir, meaning the microbial populations ... in the product, creating the final flavor according to ... Applied and Environmental Microbiology . This is the first ... sake brewery. , Many sake makers inoculate with ... Mills of the University of California, Davis, but he ...
(Date:7/24/2014)... similar counterparts in humans, affect the connections between nerve ... the hippocampus, an area of the brain that plays ... of memories. The results of the study have been ... function depends on the active communication between nerve cells, ... together into a dense network where they constantly relay ...
(Date:7/24/2014)... 24, 2014) For years, researchers and patients have ... any cell type in the bodycould provide insight into ... Yet progress has been hampered by the inability to ... their human counterparts, in part because human ESCs are ... , Now Thorold Theunissen, Benjamin Powell, and Haoyi Wang, ...
Breaking Biology News(10 mins):The microbes make the sake brewery 2A protein couple controls flow of information into the brain's memory center 2A protein couple controls flow of information into the brain's memory center 3A protein couple controls flow of information into the brain's memory center 4Whitehead Institute researchers create 'naïve' pluripotent human embryonic stem cells 2
... dark scene, attention brings to mind specific details of our ... at the Salk Institute for Biological Studies shows that the ... for its role in the control of eye and head ... findings, published in the Dec. 20, 2009, issue of the ...
... in an antibiotic-resistant bacterium is cause for concern, according ... Faculty of 1000 member Dr Johann Pitout, of ... Calgary, urges the medical community to monitor the spread ... to use more powerful antibiotics as a first response. ...
... UCLA scientists have identified a molecular switch that prevents ... 24 edition of the journal Neuron , the discovery ... ultimately leads to death in as little as 10 years. ... Americans, Huntington,s progressively deprives patients of their ability to walk, ...
Cached Biology News:Seeing without looking 2UCLA scientists find molecular switch to prevent Huntington's disease in mice 2
(Date:7/25/2014)... July 25, 2014 Lawrence Livermore scientists ... Thomson Reuters list of " The World's Most Influential ... of the 3,000 researchers who were identified by analyzing ... those who published the highest-impact work (2002-2012 and 2012-2013). ... on combustion modeling . , "This recognition is ...
(Date:7/25/2014)... TEL AVIV, Israel , July 25, 2014 /PRNewswire/ ... a clinical-stage biopharmaceutical company focused on the development and ... of liver diseases and cholesterol gallstones, today announced financial ... First Half 2014 Financial Summary: , Reported ... 30, 2014, compared with $137,000 at December 31, 2013.  ...
(Date:7/25/2014)... , July 25, 2014 /PRNewswire-iReach/ -- Xybion Corporation, ... for global corporations operating in highly regulated industries, ... first annual Global User Group Conference, Xybion International ... Philadelphia, Pennsylvania at the Sheraton ... http://photos.prnewswire.com/prnh/20140724/130263 This year,s conference ...
(Date:7/25/2014)... July 25, 2014 At the request ... granted a 60-day extension for the public comment period ... Rule for Model Aircraft established by Congress as part ... The 60-day extension establishes the new deadline for comments ... Department of Transportation/FAA notice published in the Federal Register ...
Breaking Biology Technology:Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 3Galmed Pharmaceuticals Reports First Half 2014 Financial Results 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 5Galmed Pharmaceuticals Reports First Half 2014 Financial Results 6Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3FAA Grants Comment Extension at the Request of AMA 2
... Key words: ... Imaging Beads, , ... pro-inflammatory cytokines with potent leukocyte activation and/or chemotactic activity in ... C, and CXC3) based on the number and sequential relationship of ...
... J. Chartier and H.C. Birnboim , DNA Genotek Inc., ... DNA collected with Oragene works well with TaqMan SNP Genotyping Assays. , ... detected., , ... Single-nucleotide polymorphisms (SNPs) are highly abundant, and are estimated , ...
... , , ... Research Organics, Inc.is an ISO 9001:2000 primary manufacturer and leading ... for molecular biology, , diagnostics, cell culture, ... , Founded in 1953, Research Organics pioneered manufacture ...
Cached Biology Technology:The development of a CXCR2 chemokine receptorbinding assay using the LEADseeker Multimodality Imaging System 2The development of a CXCR2 chemokine receptorbinding assay using the LEADseeker Multimodality Imaging System 3The development of a CXCR2 chemokine receptorbinding assay using the LEADseeker Multimodality Imaging System 4Oragene is compatible with TaqMan SNP genotyping 2Oragene is compatible with TaqMan SNP genotyping 3Research Organics 2Research Organics 3