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The secrets of a tadpole's tail and the implications for human healing
Date:1/13/2013

ised to find these high levels of ROS during tail regeneration. Traditionally, ROS have been thought to have a negative impact on cells. But in this case they seemed to be having a positive impact on tail re-growth."

To assess how vital the presence of ROS are in the regeneration process, Professor Amaya's team limited ROS production using two methods. The first was by using chemicals, including an antioxidant, and the second was by removing a gene responsible for ROS production. In both cases the regeneration process was inhibited and the tadpole tail did not grow back.

Professor Amaya says: "When we decreased ROS levels, tissue growth and regeneration failed to occur. Our research suggests that ROS are essential to initiate and sustain the regeneration response. We also found that ROS production is essential to activate Wnt signalling, which has been implicated in essentially every studied regeneration system, including those found in humans. It was also striking that our study showed that antioxidants had such a negative impact on tissue regrowth, as we are often told that antioxidants should be beneficial to health."

The publication of Professor Amaya's study comes just days after a paper from the Nobel Prize winner and co-discoverer of the structure of DNA, James Watson, who has suggested antioxidants could be harmful to people in the later stages of cancer.

Professor Amaya comments: "It's very interesting that two papers suggesting that antioxidants may not always be beneficial have been published recently. Our findings and those of others are leading to a reversal in our thinking about the relative beneficial versus harmful effects that oxidants and antioxidants may have on human health, and indeed that oxidants, such as ROS, may play some important beneficial roles in healing and regeneration."

The next step for the team at the Healing Foundation Centre will be to study ROS and their role in the healing and regenerat
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Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

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