Navigation Links
The secret sex life of the penicillin-producing fungus could make it more productive
Date:1/14/2013

itous discovery that a Penicillium mold, which had contaminated a bacterial culture, was able to inhibit the growth of nearby bacteria by releasing penicillin into its surroundings. Over 10 years later two scientists, Ernst Chain and Howard Florey, were the first to grow the fungus in large quantities to generate enough penicillin to treat patients. These events heralded the start of the antibiotic era, which has been one of the most important advances in medicine. Fleming, Chain, and Florey later shared the Nobel Prize in physiology/medicine. Since then it has only been possible to develop strains of P. chrysogenum with elevated production of penicillin by conventional mutagenesis.

The researchers found that sexual reproduction could be induced in P. chrysogenum when strains were mated in the dark on oatmeal with a vitamin supplement. They demonstrated that the sexual cycle could be used for strain development purposes by producing offspring with new combinations of important biotechnological properties for penicillin production, such as the removal of chrysogenin, a contaminating substance produced by the fungus. Furthermore, the team discovered that mating-type genes, which control sex in fungi, have additional roles regulating other developmental processes of biotechnological relevance.

Inducing sex in celibate fungi

Fungi are used to produce many important pharmaceutical products including statins and antibiotics, and most species involved have long been considered to be asexual. But the present findings suggest that sexual reproduction could be triggered in other supposedly asexual fungi if the mating-type genes and correct growth conditions can be identified.


'/>"/>
Contact: Lindsay Brooke
lindsay.brooke@nottingham.ac.uk
44-011-595-15751
University of Nottingham
Source:Eurekalert

Page: 1 2

Related biology news :

1. The secrets of a tadpoles tail and the implications for human healing
2. Host cholesterol secretion likely to influence gut microbiota
3. Secrets of gentle touch revealed
4. Biologists unlocking the secrets of plant defenses, 1 piece at a time
5. Fitness for toad sperm: The secret is to mate frequently
6. Pond skating insects reveal water-walking secrets
7. Biophysicists unravel secrets of genetic switch
8. Ancient genome reveals its secrets
9. New model gives hands-on help for learning the secrets of molecules
10. Decoding the secrets of balance
11. Hidden secrets in the worlds most northerly rainforests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Stem Cell scientists have set a "mouse TRAP" to ... by a recent study published in the Journal ... uses a technique called TRAP to extract cellular and ... Invented by scientists at the Rockefeller Institute for Medical ... to the protein-making machinery, or ribosomes, of the cell ...
(Date:7/11/2014)... often develop relationships with other group members to reduce ... chacma baboons the strategy for grooming activities shows a ... published in the scientific journal Biology Letters . ... is not practiced without ulterior motives. To be groomed ... individual, while grooming another individual can provide access to ...
(Date:7/11/2014)... The increased risk of kidney injury related to the ... the mass of HES molecules, according to a report ... the International Anesthesia Research Society (IARS). , The "total ... HES on cultured human renal proximal tubule cells (PTCs), ... colleagues of University Hospital Wrzburg, Austria. Other factorssuch ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... public divided about climate change because they don,t understand ... science and were more proficient in technical reasoning, would ... today online in the journal Nature Climate Change ... no. Indeed, as members of the public become more ...
... (RBC) is a critical component in the treatment ... problems. Indeed, approximately 75 million units of whole ... for processing and eventual transfusion. Despite this massive ... availability due to a combination of collection, manufacturing, ...
... the healthy growth of coral reefs in Hawaii may ... day treat human diseases, a new study led by ... Diego has revealed. An analysis led by Hyukjae ... Scripps, has shown that the seaweed, a tiny photosynthetic ...
Cached Biology News:Yale study concludes public apathy over climate change unrelated to science literacy 2Proteomic analysis of immunocamouflaged surfaces 2Nuisance seaweed found to produce compounds with biomedical potential 2
(Date:7/10/2014)... 2014 Terascala, the industry leader in ... Swahn, a former vice president of product management for ... president of marketing. Terascala’s software when combined with leading ... the highest performance and most reliable solutions for processing ... Terascala’s channel expansion and broaden its product portfolio. His ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 OMICS ... Bioanalytical techniques during 18-20 August, 2014 at Double Tree ... review the recent developments in Analytical & Bioanalytical research ... globe. , Speaking on this occasion, Dr. Srinubabu Gedela, ... Analytica Acta conference is a remarkable one in bringing ...
(Date:7/10/2014)... July 10, 2014  Franciscan St. Anthony ... capnography for respiratory monitoring outside the operating ... leaders in embracing state-of-the-art patient safety technology. ... are breathing and can alert medical caregivers ... the amount of carbon dioxide the patient ...
(Date:7/10/2014)... July 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, ... today announced an agreement with Lineagen, Inc., ... Lineagen,s NextStep Dx PLUS.  Lineagen, focused ... neurological disorders, currently offers FirstStep Dx ... service used by healthcare providers as a ...
Breaking Biology Technology:Terascala Expands Executive Team 2Terascala Expands Executive Team 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... SAIC-Frederick, Inc. and Biomatrica have begun ... which is becoming increasingly important in cancer research and ... therapies. The two organizations will focus on ... samples collected by pathologists in the clinic. Preserving nucleic ...
... be a magnet, and how can we control a magnet,s ... Igor Zutic, a theoretical physicist, has been exploring over many ... that magnets could revolutionize computing, forming the basis of high-capacity ... Today, in a commentary in Science , Zutic and ...
... Calif., May 26, 2011 MAP Pharmaceuticals, ... it has submitted a New Drug Application (NDA) to ... LEVADEX® orally inhaled migraine drug for the potential acute ... Headache Foundation, approximately 30 million people in the United ...
Cached Biology Technology:SAIC-Frederick and Biomatrica Collaborate to Improve Molecular Analysis in Cancer Research 2SAIC-Frederick and Biomatrica Collaborate to Improve Molecular Analysis in Cancer Research 3Chameleon magnets: Ability to switch magnets 'on' or 'off' could revolutionize computing 2Chameleon magnets: Ability to switch magnets 'on' or 'off' could revolutionize computing 3MAP Pharmaceuticals Submits New Drug Application to FDA for LEVADEX® Orally Inhaled Migraine Drug 2MAP Pharmaceuticals Submits New Drug Application to FDA for LEVADEX® Orally Inhaled Migraine Drug 3MAP Pharmaceuticals Submits New Drug Application to FDA for LEVADEX® Orally Inhaled Migraine Drug 4
... With increasing age, the autofluorescent ... of many cell types, including neurons. ... complicate the use of fluorescence microscopy ... of its broad excitation and emission ...
One unit is equal to 10Kb (insert DNA + vector). The final cost will increase or decrease according to the final assembled genome size. The price does not include genome annotation....
... S100 belongs to the family of calcium ... S100A is composed of an alpha and ... beta chains. S100 protein is also expressed ... Langerhans cells in skin and interdigitating reticulum cells ...
Polyclonal Antibody to Golgin-67...
Biology Products: