Navigation Links
The role of stem cells in renewing the cornea
Date:10/2/2008

A group of researchers in Switzerland has published a study appearing in the Oct 1 advance online edition of the Journal Nature that shows how the cornea uses stem cells to repair itself.

Using mouse models they demonstrate that everyday wear and tear on the cornea is repaired from stem cells residing in the corneal epithelium, and that more serious repair jobs require the involvement of other stem cells that migrate from the limbus, a region between the cornea and the conjunctiva, the white part of the eye.

The integrity of the cornea, the transparent outer layer of the eye, is critical for vision. Millions of people around the world suffer from partial or complete blindness when their corneas lose transparency. Treatment options involve corneal transplants and, more recently, stem cell therapy. The surface of the cornea is naturally in a state of constant renewal; its upper layer, or epithelium, is completely turned over once every 7-14 days. Because slow-cycling stem cells have been found in the mouse limbus, researchers have assumed that these stem cells are the ones responsible for corneal renewal.

The research led by Professor Yann Barrandon, who holds a joint appointment at EPFL and the Lausanne University Hospitals (CHUV), challenges this prevailing opinion that the limbus is the only place where corneal stem cells reside. The researchers demonstrated that the epithelium of the cornea also contains stem cells, and that these cells have the capacity to generate two different epithelial tissues: corneal (covering the transparent part of the eye) and conjunctival (covering the white part of the eye). They demonstrated experimentally that these are the cells activated in everyday corneal renewal. The stem cells residing in the limbus have a different role; they are only activated when the cornea is seriously wounded.

To explain this distribution of stem cells and the different roles played by stem cells in diff
'/>"/>

Contact: Yann Barrandon
yann.barrandon@epfl.ch
41-795-986-521
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Page: 1 2

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Newly created cancer stem cells could aid breast cancer research
3. AIDS interferes with stem cells in the brain
4. Clemson scientists shed light on molecules in living cells
5. Social habits of cells may hold key to fighting diseases
6. UF scientists reveal how dietary restriction cleans cells
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Scientists identify embryonic stem cells by appearance alone
9. Cells united against cancer
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Food and Drug Administration (FDA) for other purposes can ... human cells, including those that cause Legionnaires, disease, brucellosis, ... mBio , the online open-access journal of the American ... non-antibiotic drugs that could one day help curb bacterial ... list inhibit the growth of at least three of ...
(Date:7/28/2014)... communities showing signs of damage from the Deepwater Horizon oil ... the Gulf of Mexico. The discovery was made by a ... State University. A paper describing this work and additional impacts ... will be published during the last week of July 2014 ... of the National Academy of Sciences . , "The footprint ...
(Date:7/28/2014)... explorer Roald Amundsen reached the South Pole in 1911, ... long before any human. , Using data from 16 ... Antarctic continent, including the South Pole, a group led ... in Reno, Nevada, created the most accurate and precise ... continent. The new record, described in an article published ...
Breaking Biology News(10 mins):New route to identify drugs that can fight bacterial infections 2Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3
... threat, city and country birds do not react in the ... a new study, urban birds have changed their anti-predator behaviour ... with a predator, its only objective is to escape. However, ... their countryside counterparts, despite being from the same species. Urbanisation ...
... backbone of our modern economy. Nearly every aspect of life ... it is not just the lights that go out. In ... working. Even telephones, radios and televisions become paralyzed. If the ... gas and fuel and the functioning of respirators at intensive ...
... advances in the new and developing field of restoration ... deltas from an array of threats, Indiana University Bloomington ... Nature Geoscience . The commentary, published this week ... is disappearing from river deltas at alarming rates. And ...
Cached Biology News:City birds adapt to their new predators 2Dealing with power outages more efficiently 2Geologist calls for advances in restoration sedimentology 2
(Date:7/28/2014)... using light, developed by researchers at the University of ... considered the realm of science fiction, such as invisibility ... won,t be a reality for quite some time, the ... building blocks a few billionths of a metre across ... flies through them, and works on large chunks all ...
(Date:7/28/2014)... 2014 Sapphire Energy, Inc. , a ... appointment of biotechnology veteran James Levine as ... Levine replaces Cynthia ,CJ, Warner, who is stepping down ... of the company,s board of directors. "The ... deliver commercial scale algae-based fuels has been tremendous, from ...
(Date:7/28/2014)... The Workgroup for Electronic Data Interchange (WEDI), ... health IT to create efficiencies in healthcare information exchange, ... has developed an issue brief titled, “What is ... HPID Workgroup, a part of WEDI’s Strategic National HPID ... and Medicaid Services (CMS) to identify common misuse of ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 ... China Lubricant Industry” is a professional and ... Lubricant market. The report introduces Lubricant basic ... industry chain structure and industry overview. This ... China’s domestic market as well as global ...
Breaking Biology Technology:Building 'invisible' materials with light 2Sapphire Energy Announces New CEO James Levine 2Sapphire Energy Announces New CEO James Levine 3WEDI’s HPID Workgroup Announces Release of Issue Brief: “What is the Difference Between a Health Plan and Payer?” 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 3Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 4
... revenue increase as broad corporate changes are ... ... Nanotech, Inc. (OTC,Bulletin Board: AVNA) today reported financial results for its ... fiscal,period since the Company refocused its business model from managing the,development ...
... 16 Immunosyn,Corporation (OTC Bulletin Board: IMYN), a ... and distribution rights to,the biopharmaceutical SF-1019 from its ... the quarter ending March 31, 2008., For ... incurred $175,632.00,in general and administrative expenses and $13,393.00 ...
... in the ... ... BSX ) today announced U.S. Food and Drug Administration,(FDA) approval of ... defibrillators (CRT-D) and cardiac,resynchronization therapy pacemakers (CRT-P), both of which treat ...
Cached Biology Technology:Advance Nanotech Reports First Quarter 2008 Financial Results 2Advance Nanotech Reports First Quarter 2008 Financial Results 3Advance Nanotech Reports First Quarter 2008 Financial Results 4Advance Nanotech Reports First Quarter 2008 Financial Results 5Advance Nanotech Reports First Quarter 2008 Financial Results 6Advance Nanotech Reports First Quarter 2008 Financial Results 7Advance Nanotech Reports First Quarter 2008 Financial Results 8Advance Nanotech Reports First Quarter 2008 Financial Results 9Advance Nanotech Reports First Quarter 2008 Financial Results 10Immunosyn Corporation Files 10-Q 2Immunosyn Corporation Files 10-Q 3Boston Scientific Announces FDA Approval of New Heart Failure Lead 2Boston Scientific Announces FDA Approval of New Heart Failure Lead 3Boston Scientific Announces FDA Approval of New Heart Failure Lead 4
...
Mouse monoclonal [Ley 37D/G6] to LKB1 ( Abpromise for all tested applications). entrezGeneID: 6794 SwissProtID: Q15831...
Handles samples from from 75l to 150l...
Hybridization chamblers suitable for use with all ChIP-GLAS microarrays....
Biology Products: