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The pathway to potato poisons
Date:7/31/2013

In 1924, Science magazine reported on a fatal case of potato poisoning: James B. Matheney of Vandalia, Illinois, had gathered about one and a half bushels of tubers, which had turned green due to sunlight exposure. Two days after eating the potatoes, most of his family -- wife, two daughters and four sons -- showed symptoms of poisoning; the only exceptions were James himself, who didn't eat the potatoes, and a breast-fed baby boy. His wife, aged 45, died a week later, followed by their 16-year-old daughter. The other five members of the family recovered.

Although such fatalities are rare among human beings, farm animals often get sick or die after eating green potatoes. Symptoms include damage to the digestive system as well as loss of sensation, hallucinations and other neurological disturbances. Death can be caused by a disruption of the heart beat. The culprits are the toxic substances solanine and chaconine; their concentration rises sharply with exposure to light or during sprouting, and they protect the tubers from insects and disease.

Solanine and chaconine belong to the large family of glycoalkaloids, which includes thousands of toxins found in small amounts in other edible plants, including tomatoes and eggplant. These substances have been known for over 200 years, but only recently has Prof. Asaph Aharoni of the Plant Sciences Department begun to unravel how they are produced in plants. He and his team have mapped out the biochemical pathway responsible for manufacturing glycoalkaloids from cholesterol. Their findings will facilitate the breeding of toxin-free crops and the development of new crop varieties from wild strains that contain such large amounts of glycoalkaloids, they are currently considered inedible. On the other hand, causing plants to produce glycoalkaloids if they don't do so naturally or increasing their glycoalkaloid content can help protect them against disease.

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Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

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