Navigation Links
The path to new antibiotics
Date:8/27/2009

LA JOLLA, Calif., August 27, 2009 -- Researchers at Burnham Institute for Medical Research (Burnham), University of Texas Southwestern Medical Center and University of Maryland have demonstrated that an enzyme that is essential to many bacteria can be targeted to kill dangerous pathogens. In addition, investigators discovered chemical compounds that can inhibit this enzyme and suppress the growth of pathogenic bacteria. These findings are essential to develop new broad-spectrum antibacterial agents to overcome multidrug resistance. The research was published in the Cell journal Chemistry & Biology on August 27.

Andrei Osterman, Ph.D., an associate professor in Burnham's Bioinformatics and Systems Biology program, and colleagues, targeted the bacterial nicotinate mononucleotide adenylyltransferase (NadD), an essential enzyme for nicotinamide adenine dinculeotide (NAD) biosynthesis. NAD has many crucial functions in nearly all important pathogens and the bacterial NadD differs significantly from the human enzyme.

"It's clear that because of bacterial resistance, we need new, wide-spectrum antibiotics," said Dr. Osterman. "This enzyme is indispensable in many pathogens, so finding ways to inhibit it could give us new options against infection."

According to the National Institutes of Health, drug resistance is making many diseases increasingly difficultand sometimes impossibleto treat. They point to tuberculosis and methicillin-resistant Staphylococcus aureus (MRSA) as two pathogens that pose a serious threat to human health.

Using a structure-based approach, the team searched for low-molecular-weight compounds that would selectively inhibit bacterial NadD, but not the human equivalent, by screening, in silico, more than a million compounds. Experimental testing of the best predicted compounds against Escherichia coli and Bacillus anthracis (anthrax) led them to a handful of versatile inhibitory chem
'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. UIC researchers find promising new targets for antibiotics
2. Alternative methods proposed to detect pesticides and antibiotics in water and natural food
3. Manure management reduces levels of antibiotics and antibiotic resistance genes
4. High degree of resistance to antibiotics in Arctic birds
5. Unique fungal collection could hold key to future antibiotics
6. UIC scientists discover how some bacteria survive antibiotics
7. Class of antibiotics can enhance gene-silencing tool
8. Energy-saving bacteria resist antibiotics
9. Milk may help bacteria survive against low levels of antibiotics
10. New way to make malaria medicine also first step in finding new antibiotics
11. Groundbreaking discovery may lead to stronger antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... University School of Medicine announced today that it ... funded by the Bill & Melinda Gates Foundation. ... Gynecology and Reproductive Sciences; and Vice Chair of ... of Medicine will pursue an innovative global health ... to Assess Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) ...
(Date:11/4/2014)... published research study examining only marketing directed at ... food restaurants has found that the majority of ... to such marketing tactics. , Authored by Arizona ... the study is the first to examine the ... exterior of fast food restaurants and its relationship ...
(Date:11/4/2014)... majority of Madagascar,s 101 species of lemurs are threatened ... the rainforests they call home. A new study by ... have on rainforest tree populations, which raises concerns about ... region,s rich biodiversity. , A large proportion of trees ... Lemurs in turn disperse the seeds of their fruit ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3
... many centuries, sustained major fisheries on both sides of ... largely collapsed. A new paper in the open-access, peer-reviewed ... University of Iceland and Marine Research Institute in Reykjavik ... fisheries, due to fisheries-induced evolution. Cod fishing is ...
... Prevention Research (SPR) will hold its annual meeting, May ... Avenue, NW, Washington, D.C., 20001. The featured story ... reach authors by registering (free) for the meeting to ... schedule media interviews anytime during the meeting. , ...
... to increase in Hawaii,s mountains, deadly non-native bird ... invading most of the last disease-free refuges for ... birds. A just-published U.S. Geological Survey ... "disease invasion" by examining the present altitudinal range ...
Cached Biology News:Did the North Atlantic fisheries collapse due to fisheries-induced evolution? 2Society for Prevention Research Meeting in Washington, D.C., May 27-29, 2009 2Society for Prevention Research Meeting in Washington, D.C., May 27-29, 2009 3Jeepers creepers: Climate change threatens endangered honeycreepers 2Jeepers creepers: Climate change threatens endangered honeycreepers 3
(Date:11/26/2014)... On January, 14, 2015, UMBC’s ... D.C. science community to the UMBC campus for a ... the Protein Society, will take place from 9 a.m. ... Through discussion, presentations and workshops, the free symposium ... their role in the industry and the future of ...
(Date:11/26/2014)... PMG Research, Inc. announced today ... a network of sites that provide clinical research services to ... patient lives through its partnerships with large physician practices and ... site locations in the Southeastern United States and spans over ... board will be held by: Dr. Robert Holmes, ...
(Date:11/26/2014)... NC (PRWEB) November 25, 2014 ... Intensity Focused Ultrasound (HIFU) devices, recently participated in ... Small Renal Mass 360° .” Key opinion leaders ... therapeutic advances related to small renal masses while ... about different ablative technologies in hands-on labs. Attendees ...
(Date:11/26/2014)... (PRWEB) November 25, 2014 Continuing its ... products, earned three prestigious MarCom Awards for outstanding creative ... received a Platinum MarCom Award, the organization’s top honor, ... in St. Louis held in April of this year. ... than 14,000 attendees. Additionally, Nerium was awarded a Gold ...
Breaking Biology Technology:PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2
... OMAHA, Neb., March 14 Creighton University,law, science, ... taste,of what it takes to convert scientific research ... selected through a competitive application and,interview process -- ... for the,first time on Feb. 13. A three-year, ...
... March 14 Wyeth (NYSE: WYE ),announced today ... Annual,Global Healthcare Conference on Wednesday, March 19, 2008 at ... M. Mahady, Senior Vice,President, Wyeth and President, Wyeth Pharmaceuticals., ... at, http://www.wyeth.com and available for replay following the ...
... March 14 Diamyd Medical AB,( http://www.omxgroup.com, ticker: ... given Diamyd Medical permission to start a Phase III,clinical ... with the therapeutic,diabetes vaccine Diamyd(R)., (Logo: http://www.newscom.com/cgi-bin/prnh/20080314/297194 ... study and to be able to offer this,promising drug ...
Cached Biology Technology:NSF Funds New Entrepreneurship Program 2Wyeth to Present at the Lehman Brothers Eleventh Annual Global Healthcare Conference 2Diamyd Gets Authorization to Begin Phase III Study in the US 2