Navigation Links
The pain puzzle: Uncovering how morphine increases pain in some people
Date:1/6/2013

the culprit behind morphine-induced pain hypersensitivity. When morphine acts on certain receptors in microglia, it triggers the cascade of events that ultimately increase, rather than decrease, activity of the pain-transmitting nerve cells."

The researchers also identified the molecule responsible for this side effect of morphine. "It's a protein called KCC2, which regulates the transport of chloride ions and the proper control of sensory signals to the brain," explains Dr. De Koninck. "Morphine inhibits the activity of this protein, causing abnormal pain perception. By restoring normal KCC2 activity we could potentially prevent pain hypersensitivity." Dr. De Koninck and researchers at Universit Laval are testing new molecules capable of preserving KCC2 functions and thus preventing hyperalgesia.

The KCC2 pathway appears to apply to short-term as well as to long-term morphine administration, says Dr. De Koninck. "Thus, we have the foundation for new strategies to improve the treatment of post-operative as well as chronic pain."

Dr. Salter adds, "Our discovery could have a major impact on individuals with various types of intractable pain, such as that associated with cancer or nerve damage, who have stopped morphine or other opiate medications because of pain hypersensitivity."

Cost of pain

Pain has been labelled the silent health crisis, afflicting tens of millions of people worldwide. Pain has a profound negative effect on the quality of human life. Pain affects nearly all aspects of human existence, with untreated or under-treated pain being the most common cause of disability. The Canadian Pain Society estimates that chronic pain affects at least one in five Canadians and costs Canada $55-60 billion per year, including health care expenses and lost productivity.

"People with incapacitating pain may be left with no alternatives when our most powerful medications intensify their suffering," says Dr.
'/>"/>

Contact: Jean-Franois Hupp
jean-francois.huppe@dc.ulaval.ca
418-656-7785
Universit Laval
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New method for uncovering side effects before a drug hits the market
2. Uncovering the genomes regulatory code
3. Bedroom TV viewing increases risk of obesity in children
4. Second-hand smoke increases risk of invasive meningococcal disease in children
5. OHSU study shows that a molecule critical to nerve cells increases drammatically during hypertension
6. Cell Transplantation reports islet cell advancement increases impact on transplantation
7. Climate change increases stress, need for restoration on grazed public lands
8. Chronic kidney disease increases risk of death at all ages
9. HIV treatment use increases in the US
10. Westlake Chemical Increases Quarterly Dividend By Over 150%
11. How chronic obstructive pulmonary disease increases risk of lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Wis. , Jan. 15, 2015  BellBrook Labs, ... drug discovery, announced the launch of a TR-FRET ... the company,s Transcreener UDP Assay, a high throughput ... The new assay will allow for sensitive detection ...
(Date:1/22/2015)... and POINT ROBERTS, Washington , January 20, ... leading sectors including technology and tech stocks, releases video from ... master pickpocket and security consultant Apollo Robbins . ... talks about the Wocket™ biometric smart wallet, a product of ...
(Date:1/22/2015)... 22, 2015 Research and Markets ( ... "Global Wearable Technologies Market and Applications, Opportunities, ... and Forecast 2014-2020" report to their offering. ... devices that can be worn on the user,s ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... from Michigan State University,s departments of Electrical Engineering and ... sensor network to assess a person,s physical activity and ... Subir Biswas, participants will wear three small, wireless sensors ... that during any physical activity will measure not ...
... Sept. 15 Medivance today announced the ... non-invasive Arctic Sun® 5000 .  The new patient ... offers the fastest initiation of treatment, simplest programming capabilities ... "We beta tested the new device ...
... (Embargoed until September 14, 2010: 5:00 p.m. U.S. Eastern ... Society and other groups reveals an ominous finding: most ... logging, and wildlife tradeare now clustered in just six ... 42 ,source sites, scattered across Asia that are now ...
Cached Biology News:Wearable sensor technology to measure physical activity 2FDA Clears Medivance's Arctic Sun 5000 for Fastest, Easiest Therapeutic Temperature Management 2Last strongholds for tigers identified in new study 2Last strongholds for tigers identified in new study 3
(Date:1/22/2015)... January 22, 2015 Diagenode, Inc., ... as the Bioruptor® and complete solutions for epigenetics ... chromatin immunoprecipitation, alleviating the need for manual processing. ... needed for ChIP of histones or transcription factors ...
(Date:1/22/2015)...  Derma Sciences, Inc. (Nasdaq: DSCI ), ... care, announces that AMNIOEXCEL® and AMNIOMATRIX®, amniotic allografts ... the Premier, Inc. Regenerative Skin Grafting contract portfolio. ... and AMNIOMATRIX® product lines, which continue to be ...
(Date:12/24/2014)... BioLife Solutions , Inc. (NASDAQ: BLFS ), a ... hypothermic storage and cryopreservation freeze media and ... ("BioLife" or the "Company"), today announced that it will hold ... (the "Annual Meeting"). Because the expected date for ...
(Date:12/24/2014)... On Friday, December 19, 2014, President Obama signed ... Appropriations Act of 2015, which for the first time, ... the Congressionally Directed Medical Research Programs (CDMRP) administered by ... working in conjunction with its allies on Capitol Hill, ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
... but biology is a game of nanometers, where spatial differences ... a cell - whether it lives or dies, remains normal ... (DOE),s Lawrence Berkeley National Laboratory (Berkeley Lab) have developed a ... patterns on living cells. Chemist Jay Groves led a ...
... Northwest Biotherapeutics (OTC.BB: NWBO) (Northwest Bio) today announced, as ... the availability online of an interview of Northwest Bio ... (Logo:   http://photos.prnewswire.com/prnh/20110329/SF73084LOGO ) The ... behind DCVax® and the progress now being made in ...
... Netsmart Technologies, Inc., a leading provider of clinical ... today announced an agreement with the Los Angeles ... provision of a comprehensive behavioral health clinical, administrative, ... as the Integrated Behavioral Health Information System (IBHIS). ...
Cached Biology Technology:Berkeley Lab scientists develop new tool for the study of spatial patterns in living cells 2Berkeley Lab scientists develop new tool for the study of spatial patterns in living cells 3Northwest Bio Announces Interview of CEO Linda Powers in Today's CEO/CFO Publication 2Northwest Bio Announces Interview of CEO Linda Powers in Today's CEO/CFO Publication 3County of Los Angeles Selects Netsmart to Provide Comprehensive Behavioral Health Information System 2County of Los Angeles Selects Netsmart to Provide Comprehensive Behavioral Health Information System 3
Antibodies were affinity purified using epitopes specific to UBAP2L/NICE4 immobilized on solid support....
...
IHC detection kit for BrdU in cells and tissues...
The Hybrid Hunter Yeast Two-Hybrid System uses the activation of reporter genes to indicate positive protein-protein interactions. Two reporters are used an auxotrophic marker and lacZ....
Biology Products: