Navigation Links
The pain puzzle: Uncovering how morphine increases pain in some people
Date:1/6/2013

the culprit behind morphine-induced pain hypersensitivity. When morphine acts on certain receptors in microglia, it triggers the cascade of events that ultimately increase, rather than decrease, activity of the pain-transmitting nerve cells."

The researchers also identified the molecule responsible for this side effect of morphine. "It's a protein called KCC2, which regulates the transport of chloride ions and the proper control of sensory signals to the brain," explains Dr. De Koninck. "Morphine inhibits the activity of this protein, causing abnormal pain perception. By restoring normal KCC2 activity we could potentially prevent pain hypersensitivity." Dr. De Koninck and researchers at Universit Laval are testing new molecules capable of preserving KCC2 functions and thus preventing hyperalgesia.

The KCC2 pathway appears to apply to short-term as well as to long-term morphine administration, says Dr. De Koninck. "Thus, we have the foundation for new strategies to improve the treatment of post-operative as well as chronic pain."

Dr. Salter adds, "Our discovery could have a major impact on individuals with various types of intractable pain, such as that associated with cancer or nerve damage, who have stopped morphine or other opiate medications because of pain hypersensitivity."

Cost of pain

Pain has been labelled the silent health crisis, afflicting tens of millions of people worldwide. Pain has a profound negative effect on the quality of human life. Pain affects nearly all aspects of human existence, with untreated or under-treated pain being the most common cause of disability. The Canadian Pain Society estimates that chronic pain affects at least one in five Canadians and costs Canada $55-60 billion per year, including health care expenses and lost productivity.

"People with incapacitating pain may be left with no alternatives when our most powerful medications intensify their suffering," says Dr.
'/>"/>

Contact: Jean-Franois Hupp
jean-francois.huppe@dc.ulaval.ca
418-656-7785
Universit Laval
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New method for uncovering side effects before a drug hits the market
2. Uncovering the genomes regulatory code
3. Bedroom TV viewing increases risk of obesity in children
4. Second-hand smoke increases risk of invasive meningococcal disease in children
5. OHSU study shows that a molecule critical to nerve cells increases drammatically during hypertension
6. Cell Transplantation reports islet cell advancement increases impact on transplantation
7. Climate change increases stress, need for restoration on grazed public lands
8. Chronic kidney disease increases risk of death at all ages
9. HIV treatment use increases in the US
10. Westlake Chemical Increases Quarterly Dividend By Over 150%
11. How chronic obstructive pulmonary disease increases risk of lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... In 2015, American consumers will finally be able to ... Although touted as zero-emissions vehicles, most of the cars ... fossil fuel that contributes to global warming. , Now ... device that uses an ordinary AAA battery to produce ... electric current through two electrodes that split liquid water ...
(Date:8/21/2014)... A new study of American singles found that ... the highest orgasm rates. On average, men experience ... sexual orientation making little difference. For women, however, ... experience orgasm 62.9 percent of the time during ... pattern varies with women,s sexual orientation, with lesbian ...
(Date:8/21/2014)... skin fungus linked to dandruff, eczema and other itchy, ... even further global reachesincluding Hawaiian coral reefs and the ... , A review in the scientific journal PLOS ... the fungi of the genus Malassezia in ... datasets from around the world. , University of Hawai,i ...
Breaking Biology News(10 mins):Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2
... entities conducting research in synthetic biology worldwide grew significantly ... of an interactive map produced by the Synthetic Biology ... The map is available online at http://www.synbioproject.org/map . ... the design and construction of new biological parts and ...
... Centers for Disease Control, about one in six Americans gets ... of raw oysters in the U.S. are estimated to cost ... of health risk from eating raw oysters, Texas A&M University ... scientist Dr. Suresh Pillai and a team of researchers from ...
... 2013 Signal Hill, CA Bowman Design Group, an ... exhibits, and event marketing, is the first and only ... certification from FAMAB, the German exhibition and events industry ... established that the company met or exceeded goals set ...
Cached Biology News:Synthetic biology research community grows significantly 2Electron-beam pasteurization of raw oysters may reduce viral food poisoning 2Electron-beam pasteurization of raw oysters may reduce viral food poisoning 3Bowman Design Group is first US company awarded German FAMAB 'Sustainable Company' certification 2
(Date:8/22/2014)... Angeles (PRWEB) August 22, 2014 ... age-defying products, is in the spotlight again. Nerium ... cream and its NeriumFirmTM Body Contouring Cream to ... by Backstage Creations during the 66th Primetime Emmy® ... patented NAE-8® extract, third-party clinical trials show that ...
(Date:8/21/2014)... Institute for Molecular Medicine Finland (FIMM), University of ... novel "man and machine" decision support system for ... described in PLOS One scientific journal ... computer vision algorithms similar to those used in ... the diagnostically most relevant areas. Tablet computers can ...
(Date:8/21/2014)... , Aug. 21, 2014 Telomere ... of their Nutraceutical "TELO-20 for Dogs" with ... Telomere-lengthening supplement in the world for dogs. Telomeres ... every chromosome in the body. A wealth of ... experts in Telomere Science and Aging, including Nobel ...
(Date:8/21/2014)... KONG , Aug. 21, 2014  China Cord Blood ... announced its plan to release financial results for the ... 28, 2014, after market close in the US.  ... at 8:00 a.m. ET on Friday, August 29, 2014 ... overview of the Company,s recent developments, followed by a ...
Breaking Biology Technology:Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2
... GeoPharma, Inc. (Nasdaq:,GORX) (the "Company") announced today in an ... audience as possible it has placed both of the ... at, http://www.GeoPharmainc.com under the "Analyst Coverage" tab in ... publicly several times in,the next few months., In ...
... Rigel,Pharmaceuticals, Inc. (Nasdaq: RIGL ) today announced that ... is scheduled to present,a company overview at the BIO ... February 11 at 11:45 a.m. EST., To access ... on to http://www.rigel.com . Please connect to Rigel,s ...
... Feb. 6 Cell Therapeutics, Inc. (CTI),(Nasdaq: CTIC ; MTAX) management will ... at 1:15 PM in the West Foyer,of the Waldorf-Astoria Hotel., The presentation ... The webcast can be accessed at, http://www.cticseattle.com ., , ... BIO CEO & Investor Conference ...
Cached Biology Technology:Recent Research Reports and Near-Term Corporate Events 2Recent Research Reports and Near-Term Corporate Events 3
... Time- and temperature-controlled microwave oven ... and Antigen Retrieval of formalin-fixed, ... ease of use, high throughput ... high performance. When used in ...
... reagents and supplies, for 10 chips, ... to perform protein analysis with 10 ... system. Supplied are 3 x 520 ... stain, 60 microliters Pro260 ladder (10-260 ...
...
... submicron range are part of your production ... of particle size is important to you. ... detect the component populations in your sample ... Analyzer uses Photon Correlation Spectroscopy (PCS) , ...
Biology Products: