Navigation Links
The pain puzzle: Uncovering how morphine increases pain in some people
Date:1/6/2013

Quebec City & Toronto, January 6, 2013For individuals with agonizing pain, it is a cruel blow when the gold-standard medication actually causes more pain. Adults and children whose pain gets worse when treated with morphine may be closer to a solution, based on research published in the January 6 on-line edition of Nature Neuroscience.

"Our research identifies a molecular pathway by which morphine can increase pain, and suggests potential new ways to make morphine effective for more patients," says senior author Dr. Yves De Koninck, Professor at Universit Laval in Quebec City. The team included researchers from The Hospital for Sick Children (SickKids) in Toronto, the Institut universitaire en sant mentale de Qubec, the US and Italy.

New pathway in pain management

The research not only identifies a target pathway to suppress morphine-induced pain but teases apart the pain hypersensitivity caused by morphine from tolerance to morphine, two phenomena previously considered to be caused by the same mechanisms.

"When morphine doesn't reduce pain adequately the tendency is to increase the dosage. If a higher dosage produces pain relief, this is the classic picture of morphine tolerance, which is very well known. But sometimes increasing the morphine can, paradoxically, makes the pain worse," explains co-author Dr. Michael Salter. Dr. Salter is Senior Scientist and Head of Neurosciences & Mental Health at SickKids, Professor of Physiology at University of Toronto, and Canada Research Chair in Neuroplasticity and Pain.

"Pain experts have thought tolerance and hypersensitivity (or hyperalgesia) are simply different reflections of the same response," says Dr. De Koninck, "but we discovered that cellular and signalling processes for morphine tolerance are very different from those of morphine-induced pain."

Dr. Salter adds, "We identified specialized cells known as microglia in the spinal cord as
'/>"/>

Contact: Jean-Franois Hupp
jean-francois.huppe@dc.ulaval.ca
418-656-7785
Universit Laval
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New method for uncovering side effects before a drug hits the market
2. Uncovering the genomes regulatory code
3. Bedroom TV viewing increases risk of obesity in children
4. Second-hand smoke increases risk of invasive meningococcal disease in children
5. OHSU study shows that a molecule critical to nerve cells increases drammatically during hypertension
6. Cell Transplantation reports islet cell advancement increases impact on transplantation
7. Climate change increases stress, need for restoration on grazed public lands
8. Chronic kidney disease increases risk of death at all ages
9. HIV treatment use increases in the US
10. Westlake Chemical Increases Quarterly Dividend By Over 150%
11. How chronic obstructive pulmonary disease increases risk of lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 17, 2015 Increasing ... technological advancement to drive biometric systems market in ...   According to a recently released ... &  Opportunities, 2020 ", biometric systems market in ... growth at CAGR of over 22% through 2020. ...
(Date:4/10/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) ... Profiles - NEC" report to their offering. ... continue to supply a range of IT security management ... focus on the development of a Big Data and ... the Asia-Pacific region is a ...
(Date:4/2/2015)... -- At its 2015 ACMG Annual Clinical Genetics Meeting ... American College of Medical Genetics and Genomics (ACMG) announced ... Members of the ACMG Board of Directors serve as ... its policies and programs. ACMG is the national organization ... eventful time in medical genetics and genomics.  We are ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NEC Security Competitive Profile 2015 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... Ind. - A new, high-resolution, interactive map of U.S. ... the emissions aren,t all where we thought. "For ... northeastern United States, and it,s looking like the southeastern ... estimated previously," says Kevin Gurney, an assistant professor of ...
... Yale Universitys Scott A. Strobel, Professor of Molecular ... Schering-Plough Research Institute Award. The award is ... Biology to recognize outstanding scientific contributions made by ... will give the award lecture, titled Three Views ...
... chemical communicator, carrying impulses from neurons to skeletal ... system. Now researchers at the University of Illinois ... component of the relay system that allows acetylcholine ... appear in the current issue of Nature Structure ...
Cached Biology News:'Revolutionary' CO2 maps zoom in on greenhouse gas sources 2'Revolutionary' CO2 maps zoom in on greenhouse gas sources 3'Revolutionary' CO2 maps zoom in on greenhouse gas sources 4'Revolutionary' CO2 maps zoom in on greenhouse gas sources 5Yale University's Strobel recognized for work on RNA 2Researchers 'see' structure of open nicotinic acetylcholine ion channels 2Researchers 'see' structure of open nicotinic acetylcholine ion channels 3
(Date:5/4/2015)... BOSTON , May 4, 2015 ... development of novel therapies for neurological and neuropsychiatric ... has initiated dosing of Alzheimer,s patients in a ... candidate, GC021109, a compound developed as a potential ... disease is innovative in that it both promotes ...
(Date:5/4/2015)... 4, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ... independent team of researchers from South ... (TB4) plays an important role in accelerating the ... an experimental mouse model, by promoting blood vessel ... dermal tissue.  The research found that the underlying ...
(Date:5/4/2015)... - New Massive Open Online Course (MOOC) ... United States Medical Licensing Examination Elsevier ... information products and services, announced today that it has ... to help medical students prepare for the United States ... most daunting of the three exams medical students must ...
(Date:5/1/2015)... 2015  Northwest Biotherapeutics (NASDAQ: NWBO ) ("NW ... therapies for solid tumor cancers, announced today that the ... of a $40 million investment from Woodford investment funds ... $25 million in NW Bio on November 19, 2014.  ... with the Company for a further $40 million investment ...
Breaking Biology Technology:GliaCure Initiates Phase 1b Dosing in Alzheimer's Patients 2Researchers Report that Thymosin B4 has a Major Role in Dermal Burn Wound Healing 2Researchers Report that Thymosin B4 has a Major Role in Dermal Burn Wound Healing 3Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3
... , Sylviane Komesli, Martine Page, and ... Laboratoires Fournier S.A., France , ... and type II receptors form ligand dependent heteromeric signaling complexes, in which ... primary receptor. In the present study, we investigated the feasibility of using ...
... , ... radiometric screening assays. The Wallac MicroBeta effectively measures both plate types. , ... one above the sample and one below. , ... are conducted with the upper PM tube only. A comparison is made ...
... Heidi Grecsek , ... 710 Bridgeport Avenue , ... , The Clean Air Act amendments of 1990 ... content. Oxygenated fuel is desirable because it burns more completely, thereby reducing tailpipe emissions. ...
Cached Biology Technology:Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor 2Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor 3Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor 4Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor 5Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor 6Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor 7Counting FlashPlates on the Wallac MicroBeta 2Counting FlashPlates on the Wallac MicroBeta 3Analysis of Fuel Oxygenates by U.S. EPA Method 8260B Using Headspace Trap with GC/MS 2Analysis of Fuel Oxygenates by U.S. EPA Method 8260B Using Headspace Trap with GC/MS 3Analysis of Fuel Oxygenates by U.S. EPA Method 8260B Using Headspace Trap with GC/MS 4
...
...
Experion HighSens chips are the microfluidic chips used to perform high-sensitivity RNA analysis (picogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to ru...
... Activator of Caspase/DIABLO Liquid. In 100 ... FREEZE/THAW CYCLES. Amino acid residues 56 - 239 ... ® sequence was expressed in and purified ... along with cytochrome c during apoptosis ...
Biology Products: