Navigation Links
The next era in discovering drugs in nature's own medicine cabinet
Date:9/4/2013

New technology for discovering antibiotics, anti-cancer drugs and other medicines inside soil microbes and other natural sources is reviving a treasure hunt that already has given humanity more than 50 percent of today's prescription drugs. This new era in "bioprospecting" is the topic of the cover story in Chemical & Engineering News, the weekly newsmagazine of the American Chemical Society.

Lisa M. Jarvis, C&EN senior editor, points out that natural products are the source of about half of the modern drugs approved in the U.S. But the search for new products slowed as drug companies learned to make synthetic compounds at high speeds by the thousands. Now, the increasing availability and affordability of DNA sequencing is reviving activity in the field. It enables scientists to sample the DNA of thousands of microbes at once in search of gene clusters that could yield a new drug. Then computer models can figure out what molecules the genes encode, and organize the information in searchable databases.

The potential for discovering new medicines is high enough to attract the attention and millions of dollars in investments of some of the pharmaceutical industry's major players, including Sanofi and Novartis. The article notes that the latest research has significantly increased the number of microbial compounds being discovered and has opened a window on a vast new library of genes and gene clusters that code for previously undiscovered drugs. The flood of genetic discovery underpins expectations that potential new medicines based on natural products will be in clinical trials in humans within a few years.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers develop tools for discovering new species
2. Discovering cell surface proteins behavior
3. Drug design success propels efforts to fight HIV with a combination of 2 FDA-approved drugs
4. First update in a century in testing drugs for elemental impurities
5. New drugs to find the right target to fight Alzheimers disease
6. Alternative target for breast cancer drugs
7. Toward broad-spectrum antiviral drugs for common cold and other infections
8. Gene variants may predict who will benefit from breast cancer prevention drugs
9. New screening technique paves the way for protein drugs from bacteria
10. Soda and illegal drugs cause similar damage to teeth
11. A new strategy required in the search for Alzheimers drugs?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... world population predicted to reach 9 billion by ... that considers human-altered landscapes such as farmland, according ... habitat that supports it might be an increasingly ... three-quarters of the land surface is directly affected ... human-caused impacts such as climate change. But what ...
(Date:4/18/2014)... R.I. [Brown University] Asteroid and comet impacts can ... on regional or even global scales. But new research ... the signatures of ancient life at the time of ... geologist Pete Schultz has found fragments of leaves and ... several ancient impacts in Argentina. The material could provide ...
(Date:4/17/2014)... infection , Respiratory syncytial virus (RSV) is ... generating life-threating illness in very young and elderly ... RSV enters host cells through the fusion protein ... Small interfering peptides that prevent bundle formation limit ... highly susceptible to degradation. In this issue of ...
Breaking Biology News(10 mins):Stanford researchers rethink 'natural' habitat for wildlife 2Stanford researchers rethink 'natural' habitat for wildlife 3Stanford researchers rethink 'natural' habitat for wildlife 4Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3JCI online ahead of print table of contents for April 17, 2014 2JCI online ahead of print table of contents for April 17, 2014 3JCI online ahead of print table of contents for April 17, 2014 4JCI online ahead of print table of contents for April 17, 2014 5JCI online ahead of print table of contents for April 17, 2014 6
... have discovered that the shape of a protein ... invade the human bloodstream. This,finding, published Dec. 16 ... a vaccine that is significantly more effective at,protecting ... the shape of a large, paddle-like molecule that,Streptococcus ...
... Dartmouth Medical School geneticists have found links in the ... avenues for studying and targeting a process vital to ... The work, reported in the February 17 issue of ... plant, in prompting worm cells to self destruct. These ...
... Two compounds that zero in on cancer cells spreading ... someday give doctors a whole new weapon in the ... College of Cornell University researchers. , The compounds, called ... metastatic breast cancer cells in mice, and are the ...
Cached Biology News:New comparative toxicogenomics database 2New comparative toxicogenomics database 3Critical role in programmed cell death identified 2Critical role in programmed cell death identified 3First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers 2First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers 3
(Date:1/14/2014)... 2014 Carahsoft and CDS Federal Services ... 2014 at 2pm EST (11am PST), “Natural Language Processing: ... on how technology can turn raw, heterogeneous data into ... agencies. The online webinar will last approximately one hour. ...
(Date:1/14/2014)... , Jan. 14, 2014 As pet owners drew up their ... of them wrote: "Take better care of my furry companion." Nowadays ... clothes and top-brand carrying cases to take the little canine or ... also feel compelled to buy some pricey toys at the pet ...
(Date:1/14/2014)... and BETHESDA, Md. , ... joining together with two institutes from the National Institutes ... tools for bringing safer, more effective treatments to patients ... National Center for Advancing Translational Sciences (NCATS) and the ...
(Date:1/14/2014)...  RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology company ... addressing major unmet medical needs using RNA-targeted technologies, ... Allowance from the United States Patent and Trademark ... for the treatment of fibrosis. The patent covers ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... Oct. 10 Twenty of Britain,s most,innovative technology ... at the fifth annual SETsquared Partnership Showcase 2008. ... George Street, London, from 8am on,Thursday, October 16th, ... information technology, engineering and biotechnology., Six companies ...
... 10 Takeda Pharmaceutical Company,Limited ("Takeda") today announced ... wholly owned United States (U.S.) subsidiary,received notification that ... be able to complete its review of the ... User Fee Act (PDUFA) date of October 27,2008., ...
... 9 Pairing traditional quality,tools with innovations ... organizations reduce waste, meet customer expectations and ... Process Improvement Leaders,Produce Profits in Recessions, the ... Practices, LLC,s GLOBAL BENCHMARKING COUNCIL,executives from leading ...
Cached Biology Technology:Creators of Britain's Innovation Economy to Showcase the Technologies of the Future at the Fifth SETsquared Partnership Showcase 2008 2Creators of Britain's Innovation Economy to Showcase the Technologies of the Future at the Fifth SETsquared Partnership Showcase 2008 3FDA Continues Review of Takeda's New Drug Application for Alogliptin (SYR-322), a DPP-4 Agent for Type 2 Diabetes 2Six Sigma and Social Media: Tools for Reducing Costs, Improving Processes 2