Navigation Links
The naked mole-rat's secret to staying cancer free
Date:7/31/2013

Mice and rats have long since been a standard animal model for cancer research, mainly due to their short lifespan of four years on average and high incidence of cancer. Naked mole rats however, are a mystery among mammals. This social tiny African subterranean rodent has a maximum lifespan exceeding 30 years and most surprisingly, is cancer-resistant. The fact that so far, not a single incident of cancer has been detected makes the naked mole rat a fitting model for finding novel ways to fight cancer.

Recently, a team of researchers from the University of Rochester in New York and the University of Haifa found the naked mole rat's unique mechanism to staying cancer free- a super sugar called high-molecular-mass Hyaluronan (HMM-HA). They discovered that when secreted from the naked mole rat's cells, HMM-HA prevents cells from overcrowding and forming tumors. "Contact inhibition, a powerful anticancer mechanism, discovered by the Rochester team, arresting cell growth when cells come into contact with each other, is lost in cancer cells", explains Prof. Eviatar Nevo, from the Institute of Evolution at the University of Haifa, "The experiments showed that when HMM-HA was removed from naked mole rat cells, they became susceptible to tumors and lost their contact inhibition".

HMM-HA is a form of Hyaluronan- a long sugar polymer, naturally present as a lubricant in the extracellular matrix of the human body. It is commonly used in the treatment of arthritis or in anti-wrinkle skin care products. According to the current results, the naked mole rat cells secrete extremely high-molecular mass HA, which is over five times larger than human or mouse HA. This high-molecular-mass HA accumulates abundantly in naked mole rat tissues, owing to a more robust synthesis by a protein called HAS2 and a decreased activity of HA-degrading enzymes. When researchers compared the Has2 gene between the naked mole rat and other mammals, they discovered that two unique amino
'/>"/>

Contact: Polina Petruhin
ppetruh1@univ.haifa.ac.il
972-482-88722
University of Haifa
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists find differences in naked mole rats protein disposers
2. Naked mole rat may hold the secret to long life
3. Test developed to detect early-stage diseases with naked eye
4. Breaking up isnt hard to do -- the secret lives of corals on dark and stormy nights
5. Artificial womb unlocks secrets of early embryo development
6. Ancient Egyptian cotton unveils secrets of domesticated crop evolution
7. Cellular secrets of plant fatty acid production understood
8. Secret soil cracks linger, despite surface sealing
9. Track Atlantic bluefin tuna to learn migration, habitat secrets
10. Forensics ferret out fire beetle secret
11. Cancerous tumors deliver pro-metastatic information in secreted vesicles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... 2014  That blood pressure plays a role in human ... the medical term for high blood pressure – was first ... inflatable cuff that,s used in measuring blood pressure was invented ... new about hypertension, its triggers and its effects. In fact, ... and the best ways to treat it. For ...
(Date:12/10/2014)... Dec. 9, 2014  Wake Forest Baptist Medical Center today ... its School of Medicine. Funding for this $50 million ... that will be publicly launched next summer. ... the former 60 series R.J. Reynolds Tobacco Company complex, ... will begin immediately with plans to be ready to ...
(Date:12/5/2014)... , Dec. 4, 2014 Increased emphasis ... investments in new testing and inspection technologies. The ... rise to a range of innovative test solutions. ... of Generation Y, which is generally more inclined ... result, product development strategies of test equipment vendors ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... University researcher has identified the important role that a ... could lead to a greater understanding of stem cells. ... College of Medicine, has outlined his findings in the ... Developmental Cell . The article, "CDK5RAP2 Regulates Centriole Engagement ...
... two-thirds of toxic lead that African-American children in Cleveland ... 20th century, according to a new study in ... Case Western Reserve University say what they,ve shown in ... and reinforces concerns about the health threat for children ...
... has been one of the nation,s premier outlets for stories ... professor has put many of those stories together in a ... Though intended for the classroom, Discover magazine blogger Carl Zimmer, ... collection, The New York Times Reader -- Science and ...
Cached Biology News:Florida State researcher uncovers protein's role in cell division 2Leaded gasoline predominant source of lead exposure in latter 20th century 2Leaded gasoline predominant source of lead exposure in latter 20th century 3IU professor's new textbook uses the best science writing from the New York Times 2IU professor's new textbook uses the best science writing from the New York Times 3
(Date:12/19/2014)... Hershey, PA (PRWEB) December 19, 2014 ... a leading developer and manufacturer of needle-free injection ... an agreement with Immunomic Therapeutics, Inc. (“ITI”) for ... injection device with its LAMP™ vaccine platform. ... for an exclusive Worldwide license to the Biojector®-2000 ...
(Date:12/19/2014)... 2014 BioPlus Specialty Pharmacy ... the promotion of Nick Maroulis, Pharm.D. to the newly ... , In this position, Dr. Maroulis will continue ... the directors of our multi-site pharmacies as the company ... and during that time he has served in many ...
(Date:12/19/2014)... PLEASANTON, Calif. , Dec. 19, 2014  Roche ... acquisition of Bina Technologies, Inc. (Bina), a privately ... California , USA. Bina provides a big ... next generation sequencing (NGS) data. Bina,s proprietary on-market ... translational and academic researchers to perform fast and ...
(Date:12/19/2014)... 2014 Decision Resources Group finds that the ... 12 percent compound annual growth rate through 2023. This ... and the increasing adoption of dental implants. Growing aesthetic ... also spur demand for dental biomaterials because they can ... treatments. Other key findings from Decision Resources ...
Breaking Biology Technology:Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3
... June 30 TargeGen, Inc., a privately held ... inhibitors today announced that the Company has agreed to be ... the ultimate purchase price will depend on the achievement of ... if such milestones are fully realized. The closing of the ...
... June 30 /PRNewswire/ - Sirius Genomics, a developer of ... appointed Senior Director of Business Development. , ... "Sirius Genomics is on track with our ... in partnering with both global pharmaceutical and medical device companies as ...
... 30 SeqWright Inc., a world-wide leader ... today the expansion of its service portfolio by ... innovative RainStorm™ microdroplet-based PCR technology.  SeqWright recognizes the ... efficient and cost-effective processes that allow for automated ...
Cached Biology Technology:Sanofi-aventis to Acquire TargeGen, Inc. 2Sirius Genomics Announces Appointment of Senior Director of Business Development 2SeqWright Expands Genomics Services Offering Through New Partnership With RainDance Technologies 2
...
... The Agilent 6850 Networked GC is an ... the footprint of a standard dual-channel GC, this ... two GCs in the space of one. You ... for routine GC analyses in an instrument that ...
... GC-8A is Shimadzu's basic gas chromatograph model ... use, the GC-8A supports a single detector, ... injection port(s), and analog output. Isothermal or ... The GC-8A is only 17.3 inches (43.9 ...
... laboratory animal infusion kits reduce the time ... study while providing sterile equipment to reduce ... everything you need for one animal, including ... tethers will be cut to the exact ...
Biology Products: