Navigation Links
The mouse that ROR'ed
Date:1/2/2014

Researchers at the University of California, San Diego School of Medicine report that an oncogene dubbed ROR1, found on chronic lymphocytic leukemia (CLL) B cells but not normal adult tissues, acts as an accelerant when combined with another oncogene, resulting in a faster-developing, more aggressive form of CLL in mice.

The findings, published in the Dec. 30, 2013 Online Early Edition of PNAS, suggest ROR1 could be an important therapeutic target for patients with CLL, the most common form of blood cancer. Prevalence of CLL in the United States is high: 1 in 20 people over the age of 40 could have apparently pre-cancerous CLL-like cells in their blood. These people may develop actual CLL at a rate of about 1 percent per year. More than 15,000 new cases of CLL are diagnosed each year in the United States. Roughly 4,400 patients with CLL die annually.

The work by principal investigator Thomas Kipps, MD, PhD, Evelyn and Edwin Tasch Chair in Cancer Research, and colleagues continues a series of discoveries about ROR1. Previously, for example, they found an association between ROR1 and the epithelial-mesenchymal transition the process that occurs during embryogenesis when cells migrate and then grow into new organs during early development. CLL cells exploit ROR1 to spread disease. Called metastasis, it is responsible for 90 percent of cancer-related deaths.

In the PNAS paper, Kipps and colleagues created transgenic mice that expressed human ROR1, then observed that these mice produced B cells (a kind of white blood cell) that were abnormal and resembled human CLL cells while non-transgenic littermates did not.

Next they crossed the ROR1 mice with another transgenic mouse-type that produces an oncogene called TCL1. Oncogenes are genes that can lead to cancer development if over-expressed or mutated. The progeny of these cross-bred mice possessed both oncogenes ROR1 and TCL1 and consequently displayed an even gr
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology news :

1. H. pylori vaccine shows promise in mouse studies
2. New book on mouse models of cancer from Cold Spring Harbor Laboratory Press
3. Mouse studies reveal promising vitamin D-based treatment for MS
4. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
5. New agent inhibits HCV replication in mouse models -- No resistance seen
6. Cat and mouse: A single gene matters
7. New mouse viruses could aid hepatitis research
8. Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model
9. UT Southwestern scientists make mouse model of human cancer, demonstrate cure
10. Researchers generate a mutant mouse model useful in the treatment of neuromuscular diseases
11. Transplanted neural stem cells slows als onset and progression in mouse models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... moon of Uranus, is one of the most visually ... its relatively small size, Miranda appears to have experienced ... formation of at least three remarkable and unique surface ... coronae are visible in Miranda,s southern hemisphere, and each ... the largest, has ridges and troughs with up to ...
(Date:9/18/2014)... the International Space Station ever starts a "frequent flyers" ... status. Recently the orbiting laboratory has hosted increasing numbers ... returned from the space station in April, and another ... third experiment is planned to launch in December. , ... around the world-- and in space. Model organisms can ...
(Date:9/18/2014)... strands of nucleic acid that contain instructions for the ... our DNA is copied into RNA molecules, which then ... our cells. , Several years ago, scientists discovered ... known RNAs, this molecule is circular, and was labeled ... been known about how they are produced. Moreover, little ...
Breaking Biology News(10 mins):Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4Scientists find how mysterious 'circular RNA' is formed, claim muscular dystrophy link 2
... of flame retardants ever tested in homes found that most ... exceeded a federal health guideline. The journal Environmental Science ... 28, 12:01am Eastern. , The study led by scientists at ... household dust, the main route of exposure for people and ...
... new method of growing cardiac tissue is teaching old stem ... into cells that function like much younger ones, may one ... diseased hearts from a patient,s own stem cellsno matter what ... Stem cell therapies involving donated bone marrow stem cells run ...
... USA GSA Bulletin articles posted online ... as the San Andreas fault, California; Tibet; Mongolia; Maine; ... Argentina; the Sinai Peninsula, Egypt; British Columbia; the southern ... include the "big crisis" in the history of life ...
Cached Biology News:New study: Many flame retardants in house dust -- unsafe levels 2New study: Many flame retardants in house dust -- unsafe levels 3'Fountain of youth' technique rejuvenates aging stem cells 2GSA Bulletin: From Titan to Tibet 2GSA Bulletin: From Titan to Tibet 3GSA Bulletin: From Titan to Tibet 4GSA Bulletin: From Titan to Tibet 5GSA Bulletin: From Titan to Tibet 6GSA Bulletin: From Titan to Tibet 7GSA Bulletin: From Titan to Tibet 8GSA Bulletin: From Titan to Tibet 9GSA Bulletin: From Titan to Tibet 10GSA Bulletin: From Titan to Tibet 11GSA Bulletin: From Titan to Tibet 12GSA Bulletin: From Titan to Tibet 13GSA Bulletin: From Titan to Tibet 14GSA Bulletin: From Titan to Tibet 15GSA Bulletin: From Titan to Tibet 16GSA Bulletin: From Titan to Tibet 17GSA Bulletin: From Titan to Tibet 18GSA Bulletin: From Titan to Tibet 19GSA Bulletin: From Titan to Tibet 20GSA Bulletin: From Titan to Tibet 21
(Date:9/19/2014)... NYU Langone Medical Center have found a way to ... turning adult cells into so-called pluripotent stem cells by ... new technique in mice, the researchers increased the number ... more than 20-fold compared with the standard method. They ... should generally accelerate research aimed at using stem cells ...
(Date:9/19/2014)... 2014  An entire month is dedicated to one ... Charcot-Marie-Tooth disease (CMT) – a debilitating neuromuscular disease affecting ... atrophy, weakness, and foot and hand deformities. CMT affects ... CMT is a progressive disease, and over time patients ... devices such as leg braces, wheelchairs and scooters to ...
(Date:9/19/2014)... 19, 2014 Pfenex Inc. (NYSE MKT: PFNX), ... high-value and difficult to manufacture proteins including biosimilar therapeutics, ... 21 st Annual NewsMakers in the Biotech Industry ... Bertrand Liang , chief executive officer of Pfenex, will ... business strategy on Friday, September 26, 2014 at 10:00 ...
(Date:9/19/2014)... 19, 2014 Cereal grain scientists, ... will gather October 5–8, 2014, for the AACC ... Convention Center in Providence, Rhode Island. The comprehensive ... of food scientists, chemists, microbiologists, nutritionists, and those ... production management. To date, 1,000 attendees have registered ...
Breaking Biology Technology:NYU Langone scientists report reliable and highly efficient method for making stem cells 2NYU Langone scientists report reliable and highly efficient method for making stem cells 3September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2Pfenex to Present at Upcoming Industry Conference on September 26 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3
... Wis. - For six years, Steve Matheys served as the ... that period - 1998 to 2004 - convinced him that serving ... and better things in the executive suite. , ,Provided the company ... ,Matheys, who now serves as executive vice president of sales, marketing, ...
... mergers and acquisitions, yet many organizations overlook the technology infrastructure ... is you better know the technology and network infrastructure and ... of the organization. , ,The current dilemma of what makes ... (CBOT) getting picked up by the Chicago Mercantile Exchange ...
... higher education initiatives would increase the number of college ... has urged lawmakers to advance his spending plans for ... direct spending of $225 million to create more seats ... more faculty members. The Legislature is considering ...
Cached Biology Technology:Visions: Matheys says CIO role is good training for executive suite 2Visions: Matheys says CIO role is good training for executive suite 3Visions: Matheys says CIO role is good training for executive suite 4Technology and mergers: Getting the strategic applications 2Technology and mergers: Getting the strategic applications 3Technology and mergers: Getting the strategic applications 4
... Activins are polypeptide hormones which belong ... superfamily. The TGF- superfamily is a ... which control many aspects of development, ... Other members incude TGF-s, bone morphogenetic ...
... be able to handle larger sample volumes, automate ... as interface with telemetry systems. The AccuSampler ... dogs, pigs, and primates. The system may ... the computer can be located outside the animal ...
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
... culture or fermentation is the ability to ... make rapid adjustments in response to changes ... provide immediate analysis of key nutrients, metabolites, ... media. BioProfile analyzers are fully automated, multi-test ...
Biology Products: