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The most aggressive forms of breast cancer elude cellular control mechanisms in order to expand
Date:11/24/2010

r2 stimulates the production of the protein Lip, which deactivates the mechanisms that prevent cell division mediated by TGF-β and the senescence mediated by OIS, thereby leading to accelerated division. "Lip is the baddie in the film. It affects TGF-β and OIS function, both tumour suppression mechanisms", explains Gomis.

Towards more rational drug administration

One of the problems associated with Herceptin is that after long periods of treatment patients begin to develop drug resistance. This study shows that tumour cells that produce an excess of Lip continue to grow in the presence of the drug. This observation indicates that part of the resistance derives from the increase in Lip shown by these individuals.

"In patients that have an alteration in Her2 plus an increase in Lip, treatment with Herceptin may not be as effective. It should be remembered that this drug acts only against the membrane protein Her2", explains Gomis. These discoveries highlight the need to rationalise drug administration, from patient to patient, and to provide new data for the design of novel pharmaceutical agents against cancer that improve its diagnosis and treatment.


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Contact: Nuria Noriega
nuria.noriega@irbbarcelona.org
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

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