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The medium is the message: Manipulating salmonella in spaceflight curtails infectiousness
Date:12/12/2008

d shear and genetic regulation of pathogenic virulencecombine and interact during the infection process? While the current research provides tantalizing hints, a full understanding of the complex interplay of forces and the in vivo mechanisms of Salmonella pathogenesis await further research.

Fortunately, new opportunities for study are opening up, which may illuminate these issues. NASA is one of the primary partners in the construction and operation of the International Space Station (ISS), a semi-permanent research platform allowing for further investigations into microbial responses to low fluid shear environments. Because cells cultured in microgravity exhibit biomedically relevant phenotypes that can not be observed using traditional experimental approaches, Nickerson believes the therapeutic benefits of such research will extend beyond infectious pathogens like S. typhimurium, eventually inspiring new clinical approaches to cancer, aging, bone and muscle wasting diseases, among other earthly afflictions.

"We can use the innovative research platform of the ISS to contribute to these new translational advances for the development of new strategies to globally advance human health."


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Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

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