Navigation Links
The medium is the message: Manipulating salmonella in spaceflight curtails infectiousness
Date:12/12/2008

at appears to trigger an intensification of virulence in Salmonella grown in LB medium. As Nickerson points out, "No one had thought to look at a mechanical force like fluid shear on the disease-causing properties of a microorganism."

If a rolling stone gathers no moss, a bacterium like S. typhimurium appears to gather virulence when its movement is slowed down and fluid shear across its surface is minimized. Nickerson speculates that Salmonella encounters just such conditions not only during spaceflight but also in vivo in an infected individual when the bacterium makes contact with an intestinal host cell and becomes ensnared in the fingerlike projections known as microvilli.

Thus, space travel may trick the microbes into behaving as though they were in an environment hospitable to cell infection, thereby switching on an increased virulence response, given appropriate environmental preconditions. "They're responding to an environmental signal that they're used to seeing right here on earth, during the natural course of the infectious disease process," Nickerson states, emphasizing that this response is masked in traditional microbial studies performed using lab cell cultures, which fail to replicate the low fluid shear conditions found in vivo, particularly in the gastrointestinal tractSalmonella's favored site of infection.

One result of spaceflight not replicated in the earthly bioreactor simulations was the formation of what appear to be biofilmsconglomerations of bacterial cells associated with infectious virulence. Nickerson emphasizes the potential importance, should such findings be confirmed. Up to 70 percent of bacterial infections in humans may be associated with the formation of such biofilms, which seem to arm bacterial pathogens with formidable resistance to the host's immune system as well as to antibiotics.

How do the disparate variablesextracellular phosphate concentration, mechanical forces like flui
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Multiple Sclerosis: new MRI contrast medium enables early diagnosis in animal model
2. PharMEDium Announces National Rollout of Electronic 222 Ordering Initiative
3. Mice roar message: genetic change happens fast
4. ETH Zurich study on salmonella self-destruction
5. Sesame seed extract and konjac gum may help ward off Salmonella and E. coli
6. From foe to friend: Researchers use salmonella as a way to administer vaccines in the body
7. Fruit flies show how salmonella escapes immune defenses
8. Understanding, combating foodborne pathogens E. coli 0157 and salmonella
9. Spaceflight shown to alter ability of bacteria to cause disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The medium is the message: Manipulating salmonella in spaceflight curtails infectiousness
(Date:4/13/2015)... According to a recently ... & Opportunities, 2020", the global biometrics market is ... till 2020. The biometrics market is garnering attention ... review of biometric management systems. The constant development ... greater efficiency, are resulting in increasing installation of ...
(Date:4/6/2015)... OXFORD, Conn. , Apr. 6, 2015 /PRNewswire/ ... the "Company"), a biometric authentication company focused on ... it has filed provisional patent 62/143028 for ... CLOSE-PROXIMITY COMMUNICATIONS AND ENERGY TRANSFER  NXT-ID introduces ... wireless payments. This patent surrounds the use of ...
(Date:4/1/2015)... , Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, ... Wocket smart wallets is underway to early access pre-order ... group includes usage at retail outlets including Walmart, Target, ... Users report Wocket was accepted at all outlets and ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... Calif. , April 15, 2013  Medbox, Inc. (OTC ... industry specific consulting services and patented systems to various ... the standard bearer of corporate governance and transparency in the ... to its shareholders concerning the status of past, present, ...
... April 14, 2013) Through a collaborative genome-wide ... variations that are associated with heart rate. Since ... findings could provide a better understanding of genetic regulation ... identifying targets for new drugs to treat cardiovascular disease. ...
... NEW ORLEANS (April 14, 2013)Drug-eluting stents can keep ... leg, suggests research being presented at the Society ... New Orleans. "Peripheral arterial disease (or PAD) ... population and the obesity and diabetes epidemics," said ...
Cached Biology News:Medbox Positions Itself as the Leader on Wall Street in the Legalized Marijuana Industry 2Medbox Positions Itself as the Leader on Wall Street in the Legalized Marijuana Industry 3Medbox Positions Itself as the Leader on Wall Street in the Legalized Marijuana Industry 4Medbox Positions Itself as the Leader on Wall Street in the Legalized Marijuana Industry 5Mount Sinai study identifies new gene variations associated with heart rate 2Drug-coated stents prevent leg amputation 2
(Date:5/6/2015)... May 6, 2015 Dr Jaspreet Singh ... University, will deliver a speech at the 2015 Asian Starch ... Shanghai New Expo Center.  , ... to attendees the topic: ,Potato Starch: A Potential Source ... Foods., Co-editor of a 528 page text ...
(Date:5/5/2015)... 5, 2015 /PRNewswire/ - Aptose Biosciences Inc. (NASDAQ: APTO, TSX: ... for the three months ended March 31, 2015 and ... are in Canadian dollars. Effective July ... from May 31 to December 31. As a result ... is for the three months ended March 31, 2015, ...
(Date:5/5/2015)... 05, 2015 Hayden-McNeil is ... develop custom course materials for smaller courses. This program ... low as 200 students. , “I’m very excited ... of higher education instructors,” said Jeff McCarthy, Hayden-McNeil president. ... can do our part to make education both more ...
(Date:5/5/2015)... IN (PRWEB) May 05, 2015 The ... the state of Indiana, led by Indiana Gov. Mike ... Day. The AMA Foundation will host a Family Fest ... celebration. All proceeds will benefit the Wounded Warrior Project. ... the Academy of Model Aeronautics—the country’s foremost organization for ...
Breaking Biology Technology:Potato Starch: A Potential Source for the Creation of Next Generation Bulk-ingredients and Smart Foods 2Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 2Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 3Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 4Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 5Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 6Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 7Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 8Hayden-McNeil Expands Publishing Program to Service Lower Enrollment Courses 2State of Indiana proclaims August 15 as Model Aviation Day 2
... Support R&D Efforts and Clinical Trials Advancing,the ... Oct. 3 Micromet, Inc. (Nasdaq:,MITI) ("Micromet" ... proprietary antibodies for the treatment of cancer, ... has closed its previously,announced $40 million private ...
... Ap3ana, CTI,s ,personalized medicine, venture, SEATTLE, Oct. ... ) announced today that Christina A. Waters, Ph.D., ... Pharma and formerly Director of,Scientific Development at Genomics ... President of CTI Europe. Based in Bresso, Italy,CTI ...
... Dr. Phaedon Avouris of IBM and Professor Tony Heinz ... Springer Prize for Applied Physics on 27 September 2008 ... luminaries of the field. The Julius Springer Prize for ... and innovative contribution to the field of applied physics. ...
Cached Biology Technology:Micromet Closes $40 Million Private Equity Placement 2Micromet Closes $40 Million Private Equity Placement 3Micromet Closes $40 Million Private Equity Placement 4Former Scientific Director at Genomics Institute of Novartis Research Foundation Named President of Cell Therapeutics Europe 2Former Scientific Director at Genomics Institute of Novartis Research Foundation Named President of Cell Therapeutics Europe 3Former Scientific Director at Genomics Institute of Novartis Research Foundation Named President of Cell Therapeutics Europe 4Nanoscale carbon materials research wins the 2008 Julius Springer Prize for Applied Physics 2
... (PR) Competitor Assay Kits are ideal ... receptor binding compounds using fluorescence polarization ... fusion of glutathione transferase to the ... receptor [PR-LBD(GST)] and a proprietary, fluorescently-tagged ...
... Protein A and Protein G bind ... immunoglobulins. Protein A and Protein G conjugates ... purify immunoglobulins (antibodies) and immunoglobulin subtypes from ... and other biological fluids. These reagents are ...
... instrument engineered to match the speed of ... of research centers worldwide. It uses 1.5 ... ideally suited for high-speed temperature cycling due ... surface-area-to-volume ratio. ,By combining glass capillary tubes ...
Yellow oily liquid. Contains 85% Drakeol 5NF, 15% Arlacel A (mannide monooleate emulsifier). Heat sterilized. Contains zero colony forming units/ml. ...
Biology Products: