Navigation Links
The loss of a protein makes 'jump' the tumor to the lymph node
Date:3/6/2012

Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the mechanisms responsible for this process is one of the top goals of cancer research. The metastatic process involves a series of steps chained where the primary tumour invades surrounding tissues and ends spreading throughout the body. Ones of the first tissues undergoing metastasis are the lymph nodes surrounding the tumour.

A study, led by the researcher at the Bellvitge Biomedical Research Institute (IDIBELL), Manel Esteller, published in the Journal of Pathology, had identified a mechanism that explains how cancer cells escape from its original site to the lymph nodes. Investigations have uncovered that metastatic tumour cells that grow in the lymph nodes of patients with melanoma and head and neck tumours lose the activity of a protein called cadherin-11.

The normal function of this protein is to act as the anchor of a ship to fix the cells in a specific position and prevent movement. Inactivation of cadherin-11 gene causes the loss of this fixation and tumour cells "jump" to neighboring organs and structures, such as lymph nodes.

The study is an example of translational and multidisciplinary research, involving basic research laboratories, the medical oncology service at the Catalan Institute of Oncology (ICO) and the Pathology Service of the Bellvitge University Hospital.

The study coordinated by the director of the Cancer Epigenetics and Biology Program at IDIBELL, ICREA researcher and professor at the University of Barcelona, Manel Esteller, also proposes that the process can be reversed because, in models in vitro and in vivo, the recovery of protein activity cadherin-11 caused a slowing of tumour growth and decreased ability to generate metastases.

This possibility needs to be studied in international clinical trials, but it is a promising starting point in studying the biology of metastasis and how to act therapeutically in this area.


'/>"/>

Contact: Arantxa Mena
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. Photonic crystal biosensors detect protein-DNA interactions
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. Dont forget the vitamin A when working with its carrier protein
4. Saliva proteins could help detection of oral cancer
5. The structure of the Mre11 protein bound to DNA
6. New lab manual focuses on essential methods for purifying and characterizing proteins
7. Proteins in sperm unlock understanding of male infertility says new study
8. Response to immune protein determines pathology of multiple sclerosis
9. Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
10. Human protein atlas will help pinpoint disease
11. How neuronal activity leads to Alzheimers protein cleavage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
(Date:3/27/2017)... March 27, 2017  Catholic Health Services (CHS) ... Systems Society (HIMSS) Analytics for achieving Stage 6 ... sm . In addition, CHS previously earned a ... using an electronic medical record (EMR). ... level of EMR usage in an outpatient setting.  ...
(Date:3/22/2017)... VILNIUS, Lithuania , March 21, 2017 /PRNewswire/ ... identification and object recognition technologies, today announced the ... development kit (SDK), which provides improved facial recognition ... safety cameras on a single computer. The new ... algorithms to improve accuracy, and it utilizes a ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... 23, 2017 , ... A recent survey conducted by the Weed Science Society ... weed in 12 categories of broadleaf crops, fruits and vegetables, while common lambsquarters ranks ... and Canada participated in the 2016 survey, the second conducted by WSSA. A ...
(Date:5/23/2017)... ... May 23, 2017 , ... Vortex Biosciences , provider of circulating tumor ... circulating tumor cells using Vortex microfluidic technology ” in Nature Precision Oncology on May ... Dino Di Carlo and Dr. Matthew Rettig at the University of California, Los Angeles. ...
(Date:5/23/2017)... ... May 23, 2017 , ... Customers often prefer ... again and again. METTLER TOLEDO has released two new videos that show how ... integration of the ACT350 into Siemens and Allen Bradley PLCs is easy and ...
(Date:5/21/2017)... , ... May 20, 2017 , ... ... helps avoid the lengthy trial and error process by finding the right antidepressant ... can also strengthen the doctor-patient relationship through a personalized approach to treatment. ...
Breaking Biology Technology: