Navigation Links
The loss of a protein makes 'jump' the tumor to the lymph node
Date:3/6/2012

Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the mechanisms responsible for this process is one of the top goals of cancer research. The metastatic process involves a series of steps chained where the primary tumour invades surrounding tissues and ends spreading throughout the body. Ones of the first tissues undergoing metastasis are the lymph nodes surrounding the tumour.

A study, led by the researcher at the Bellvitge Biomedical Research Institute (IDIBELL), Manel Esteller, published in the Journal of Pathology, had identified a mechanism that explains how cancer cells escape from its original site to the lymph nodes. Investigations have uncovered that metastatic tumour cells that grow in the lymph nodes of patients with melanoma and head and neck tumours lose the activity of a protein called cadherin-11.

The normal function of this protein is to act as the anchor of a ship to fix the cells in a specific position and prevent movement. Inactivation of cadherin-11 gene causes the loss of this fixation and tumour cells "jump" to neighboring organs and structures, such as lymph nodes.

The study is an example of translational and multidisciplinary research, involving basic research laboratories, the medical oncology service at the Catalan Institute of Oncology (ICO) and the Pathology Service of the Bellvitge University Hospital.

The study coordinated by the director of the Cancer Epigenetics and Biology Program at IDIBELL, ICREA researcher and professor at the University of Barcelona, Manel Esteller, also proposes that the process can be reversed because, in models in vitro and in vivo, the recovery of protein activity cadherin-11 caused a slowing of tumour growth and decreased ability to generate metastases.

This possibility needs to be studied in international clinical trials, but it is a promising starting point in studying the biology of metastasis and how to act therapeu
'/>"/>

Contact: Arantxa Mena
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Photonic crystal biosensors detect protein-DNA interactions
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. Dont forget the vitamin A when working with its carrier protein
4. Saliva proteins could help detection of oral cancer
5. The structure of the Mre11 protein bound to DNA
6. New lab manual focuses on essential methods for purifying and characterizing proteins
7. Proteins in sperm unlock understanding of male infertility says new study
8. Response to immune protein determines pathology of multiple sclerosis
9. Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
10. Human protein atlas will help pinpoint disease
11. How neuronal activity leads to Alzheimers protein cleavage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Scientists at The New York Stem Cell ... to creating a viable cell replacement therapy for ... , For the first time, NYSCF scientists generated ... samples of patients with primary progressive multiple sclerosis ... induce these stem cells into becoming oligodendrocytes, the ...
(Date:7/24/2014)... Acoustic disturbance has different effects on different species ... the Universities of Bristol and Exeter which tested ... sooner to a flying seagull predator model when ... observed in European minnows. , Lead author ... Sciences said: "Noise levels in many aquatic environments ...
(Date:7/24/2014)... 3.5 billion years of evolutionary trial and error, is ... may be reaching a tipping point. , In a ... published in Science , an international team of ... is contributing to what appears to be the early ... , Since 1500, more than 320 terrestrial vertebrates have ...
Breaking Biology News(10 mins):NYSCF scientists 1 step closer to cell therapy for multiple sclerosis patients 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 3
... good news from University of Illinois broccoli researchers this ... broccoli lacks the ability to form sulforaphane, the cancer-fighting ... how the food industry can act to restore the ... that companies can use to make frozen broccoli as ...
... losing about 1.6 million tonnes of carbon per year from ... and carbon accounts, according to new research.,Top soil is rich ... by events such as the ,Red Dawn, in Sydney in ... atmosphere it changes the amount and location of soil carbon. ...
... with carpal tunnel syndrome one of the most common ... research collaboration led by an Arizona State University biomedical engineering ... and Mark Ross were recently awarded a grant of $93,000 ... to quantify the effects of carpal tunnel release surgery on ...
Cached Biology News:Illinois scientists put cancer-fighting power back into frozen broccoli 2Soil carbon 'blowing in the wind' 2ASU-Mayo research project targets carpal tunnel syndrome diagnosis 2
(Date:7/24/2014)... at the University of Delaware, is known worldwide ... engineering, environmental sustainability and electronics. , His early ... a well-defined, crystalline structure. At the atomic scale, ... zeolites can separate molecules with size differences of ... a nanometer), making them useful to the chemical ...
(Date:7/24/2014)... Livermore, California (PRWEB) July 24, 2014 ... due to advances in modeling lithium-ion battery storage ... could benefit from a theoretical model created at ... Rice University that predicts how carbon components ... for energy storage emphasizes the urgent need for ...
(Date:7/24/2014)... 24, 2014 2014 Deep Research ... is a professional and in-depth research report on ... Sulphate basic information, including its definition, classification, ... This research covers the international market analysis, including ... analysis covering macroeconomic environment & economic situation analysis, ...
(Date:7/24/2014)... July 24, 2014 The first part ... Escalation in First in Human Studies” will cover comprehensive ... go/no-go decisions. , With increasing R&D costs and declining ... need to maximize the knowledge collected in early Phase ... improve success in late stage development. , Next, the ...
Breaking Biology Technology:University of Delaware researcher describes new approach for creating organic zeolites 2Getting More Life out of Lithium-ion Batteries 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4Best Practices for Optimizing Dose Escalation in First in Human Studies, New Webinar August 6th Hosted by Xtalks 2
... Derek Cody and Laura G. Leff, Department of Biological Sciences, ... Introduction , ... because of difficulties in culturing native bacteria ... that may be encountered. The morphological and physiological , ...
... James R. Wong, Ph.D. and Wei-Yu Lin, Bio-Rad Laboratories, , ... Summary , A double pulse format for ... transient expression than a single exponential decay , pulse. ... double pulse revealed that transformation was due almost exclusively to , ...
... Li Tian, PhD, Bio-Rad Laboratories, 2000 Alfred,Nobel Drive, Hercules, CA 94547 USA, ... The Benchmark Plus microplate reader is a new monochromator- ... offers superior convenience, accuracy, and flexibility. , ... feature has been designed in Microplate Manager ...
Cached Biology Technology:Analysis of Bacterial Assemblage Genetic Diversity in Environmental Samples Using the DCode System 2Analysis of Bacterial Assemblage Genetic Diversity in Environmental Samples Using the DCode System 3Analysis of Bacterial Assemblage Genetic Diversity in Environmental Samples Using the DCode System 4Analysis of Bacterial Assemblage Genetic Diversity in Environmental Samples Using the DCode System 5Transient Gene Expression Following Single and Double Exponential Decay Electroporation Pulses 2Transient Gene Expression Following Single and Double Exponential Decay Electroporation Pulses 3Transient Gene Expression Following Single and Double Exponential Decay Electroporation Pulses 4Transient Gene Expression Following Single and Double Exponential Decay Electroporation Pulses 5Benchmark Plus Microplate Reader Scan Well Feature 2Benchmark Plus Microplate Reader Scan Well Feature 3
Rabbit polyclonal to XPC ( Abpromise for all tested applications). Antigen: Synthetic peptide from N-terminus of Human XPC conjugated to a carrier protein Entrez Gene ID: 7508 Swiss ...
Chicken polyclonal to HADHSC - Azide free ( Abpromise for all tested applications). Antigen: Amino acids 57-314 of HADHSC Entrez GeneID: 3033 Swiss Protein ID: Q16836...
Rabbit polyclonal to FANCG ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSRQTTSVGSSC, corresponding to amino acids 1 - 12 of Human FANCG. Entrez GeneID: 2189 Swis...
...
Biology Products: