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The long, err, short of it
Date:3/25/2012

edside, Ruff points out that measuring telomere length may be useful in a clinical setting, providing a sort of predictor for cardiovascular events.

"Telomere shortening may represent some sort of 'biological clock' which integrates the cumulative effect of environmental and genetic stresses on the body, both of which can contribute to cardiovascular events." said Ruff.

The researchers will continue to validate their findings to see if the relationship between telomere length and cardiovascular outcomes holds true in broader populations of patients. They also plan on experimenting on whether the rate of telomere shortening over time also predicts adverse cardiovascular events.

"In the future, we hope to identify clinical, biochemical and genetic characteristics that predict telomere shortening," said Ruff. "We hope to have the ability to determine if therapies and medications that impact these processes may delay telomere attrition and lessen the risk of cardiovascular events in these patients."


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Contact: Marjorie Montemayor-Quell
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
Source:Eurekalert

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