Navigation Links
The leading edge of stress: New genomic, optogenetic and epigenetic findings
Date:11/15/2011

Washington Research released today uses the latest genetic tools to explore how stress alters brain function, leading to anxiety, depression, and other stress-related mood disorders. The research was presented at Neuroscience 2011, the Society for Neuroscience's annual meeting and the world's largest source of emerging news about brain science and health.

Stress has many meanings; in neuroscience stress is generally defined as any kind of change that causes physical or psychological strain. Today's findings provide more clues as to how different kinds of stress alter genes and brain function clues that may explain behavior and mood changes in stress-related disorders.

Specifically, the research released today shows that:

  • Brain cells that produce serotonin may be critical for stress to affect mood and behavior. Researchers found that "silencing" serotonin cells blocked increased fear behaviors in stressed mice (Michael Baratta, PhD, abstract 719.07, see attached summary).

  • An extra copy of a single gene, general transcription factor II-I (GTF2I), is linked to separation anxiety in both mice and humans (Lucy Osborne, PhD, abstract 901.28, see attached summary).

  • The effects of prenatal stress can be passed across generations in male mice. The study suggests that epigenetics are to blame for disruptions in male brain development in mice that experienced prenatal stress and their offspring (Christopher Morgan, abstract 190.02, see attached summary).

Another recent finding discussed shows that:

  • Female mice with a modification in the serotonin transporter gene are particularly vulnerable to prenatal stress. This finding suggests that vulnerability to emotional disorders is determined by a complex interaction of genes and environment, including prenatal stress (Sissi Jakob, MSc, see attached speaker's summary).

"Specific types of stress are a serious risk factor for m
'/>"/>

Contact: Kat Snodgrass
ksnodgrass@sfn.org
Society for Neuroscience
Source:Eurekalert

Page: 1 2

Related biology news :

1. Evolution offers clues to leading cause of death during childbirth
2. Misleading morphology: 3 European parasitoid wasp species are seasonal forms of just 1
3. SomaLogic announces agreement with leading global pharma company to accelerate R&D
4. National labs leading charge on building better batteries
5. Joslin researchers identify pathways leading to activation of good fat
6. Firewood movement leading cause of oak infestation in San Diego County
7. John Theurer Cancer Center researchers shared 14 leading edge studies at recent ASCO meeting
8. Editor-in-chief of leading robotics journal responds to Obamas robotics initiative
9. UC Riverside licenses leading South African company to market GEM avocados
10. UCSB urban ecosystem research featured in leading ecology journal
11. All wrapped up: K-State researchers graphene cloak protects bacteria, leading to better images
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... to ignore, but they are the ultimate source of ... are increasingly dependent on algae, too, to suck up ... to the bottom of the ocean. Now, by using ... have evidence showing that viruses infecting those algae are ... when all else stays essentially the same, and this ...
(Date:8/21/2014)... Nine researchers from Beth Israel Deaconess Medical Center (BIDMC ... World,s Most Influential Scientific Minds 2014," a comprehensive ... a web resource for science metrics and research performance ... the most influential "are performing and publishing work that ... their science," according to a Thomson Reuters statement. Researchers ...
(Date:8/21/2014)... to Wednesday, Oct. 18-22, 2014 , WHERE: ... Drive, San Diego, CA 92101 , WHAT: ... presentations of the latest research in human genetics. ... featuring high-scoring abstracts on rare genetic variants in ... and treatment for sun sensitivity (Saturday, Oct. 18, ...
Breaking Biology News(10 mins):Viruses take down massive algal blooms, with big implications for climate 2BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3American Society of Human Genetics 2014 Annual Meeting 2
... antibiotic appears to be a safe treatment for stroke and ... is currently the only FDA-approved drug therapy, researchers report. ... and Oregon found the drug well tolerated even at three-and-one-half ... arthritis, according to a research team led by the Medical ...
... flowers to produce pretty petals or sweet scents now ... new types of flowers. DNA analysis of wild evergreen ... of the plant could be derived from hybrids cross-breeds ... the rich biodiversity of the natural world, as it shows ...
... carbon nanotubes (hollow tubes of carbon atoms), MIT chemical ... 100 times more than a regular photovoltaic cell. Such ... energy, potentially allowing much smaller and more powerful solar ... a photovoltaic cell, you could have little spots that ...
Cached Biology News:Antibiotic appears safe for stroke patients and good companion for tPA 2Antibiotic appears safe for stroke patients and good companion for tPA 3Nature's gift for gardening may hold key to biodiversity 2MIT researchers develop a way to funnel solar energy 2MIT researchers develop a way to funnel solar energy 3
(Date:8/21/2014)...  BioSpecifics Technologies Corp. (NASDAQ: BSTC ... collagenase-based products marketed as XIAFLEX ® (collagenase ... XIAPEX ® in the EU, today announced ... Phase 2a study of CCH for the potential ... results showed that all three doses of CCH ...
(Date:8/21/2014)... Institute for Molecular Medicine Finland (FIMM), University of ... novel "man and machine" decision support system for ... described in PLOS One scientific journal ... computer vision algorithms similar to those used in ... the diagnostically most relevant areas. Tablet computers can ...
(Date:8/21/2014)... 21, 2014 2014 Deep ... is a professional and in-depth research report ... provides basic Seaweed Fertilizer information, including Seaweed ... structure as well as industry overview. This ... domestic market as well as global industry ...
(Date:8/21/2014)... Emmetsburg, IA (PRWEB) August 21, 2014 ... Project LIBERTY Opening , The Court of His Majesty ... King will attend the Grand Opening of POET-DSM Advanced ... on Wednesday, Sept. 3. , The King will take ... formal opening activity, scheduled for 11 a.m.-12:20 p.m. and ...
Breaking Biology Technology:BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3
... Commission,s Joint Research Centre (JRC) has just launched ... representative range of 25 different types of reference ... consumer protection and confidence in many innovative applications ... promising technological developments. By enabling a harmonised risk ...
... CANTEL MEDICAL CORP. (NYSE: CMN ), through ... prevention and control business by purchasing the sterilization monitoring ... Colorado, ConFirm is one of the leading providers of ... ConFirm offers both a mail-in service and in-office spore ...
... LONG BRANCH, N.J., Feb. 14, 2011 Pharma ChemOutsourcing ... the first wave of 50 speakers from a diverse ...   "The biotechs all have clinical ... limited capital and human resources demonstrate how they have ...
Cached Biology Technology:Small material, big impact 2Cantel Medical Acquires the Sterilization Monitoring Business of ConFirm Monitoring Systems, Inc. 2Cantel Medical Acquires the Sterilization Monitoring Business of ConFirm Monitoring Systems, Inc. 3Pharma ChemOutsourcing 2011 Unveils First Wave of 50 Biotech Chemist Speakers for September 12-15 Show in New Jersey 2