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The influence of estrogen on female mood changes
Date:1/21/2012

chology and endocrinology. The paper was published in Science China: Life Sciences. The authors hope the study will contribute to a better understanding of how estrogen affects female mood.

Estrogen has a wide range of effects on the body and brain. It exerts influence on the central nervous system through complex mechanisms of physiology and psychology. It can affect the generation and efficiency of neurotransmitters in the amygdala, hippocampus and prefrontal lobes, which are important brain areas related to emotion and cognition. It also plays a role in changing emotional behavior by acting on the hypothalamuspituitaryadrenal (HPA) axis. The genetic transcription of estrogen receptors can modulate emotional behavior, and estrogen can influence emotional processing via neuropsychological factors. It enhances the coding of emotion and recognition accuracy for facial expressions. Estrogen can also affect emotional arousal and change the intensity of emotional experiences.

Clinicians have long recognized estrogen's therapeutic potential for mood change. Self-rated depression scores among oophorectomized women with depressive symptoms are significantly decreased by administration of estrogen, alone or in combination with the selective serotonin reuptake inhibitor fluvoxamine. In addition, estrogen replacement therapy is often used in postmenopausal women to improve mood, energy level and general well-being. However, estrogen is not simply a natural "physiological protectant". Some have reported that estrogen administration does not improve mood and even causes fear and anxiety. Therefore, the impact of estrogen on emotion varies and may depend on the individual's current state and the situation.

The authors believe that hormones do not exert an absolute and singular effect on the body. They regulate physical and psychological changes in numerous dimensions. Thus, the influence of estrogen on women's emotion is related to multiple system
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Contact: Luo Yue-Jia
luoyj@bnu.edu.cn
Science in China Press
Source:Eurekalert

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