Navigation Links
The importance of gene regulation for common human disease
Date:9/16/2007

A new study published in Nature Genetics on Sunday 16 September 2007 show that common, complex diseases are more likely to be due to genetic variation in regions that control activity of genes, rather than in the regions that specify the protein code.

This surprising result comes from a study at the Wellcome Trust Sanger Institute of the activity of almost 14,000 genes in 270 DNA samples collected for the HapMap Project. The authors looked at 2.2 million DNA sequence variants (SNPs) to determine which affected gene activity.

They found that activity of more than 1300 genes was affected by DNA sequence changes in regions predicted to be involved in regulating gene activity, which often lie close to, but outside, the protein-coding regions.

"We predict that variants in regulatory regions make a greater contribution to complex disease than do variants that affect protein sequence," explained Dr Manolis Dermitzakis, senior author from the Wellcome Trust Sanger Institute. "This is the first study on this scale and these results are confirming our intuition about the nature of natural variation in complex traits.

"One of the challenges of large-scale studies that link a DNA variant to a disease is to determine how the variant causes the disease: our analysis will help to develop that understanding, a vital step on the path from genetics to improvements in healthcare."

Past studies of rare, monogenic disease, such as cystic fibrosis and sickle-cell anaemia, have focused on changes to the protein-coding regions of genes because they have been visible to the tools of human genetics. With the HapMap and large-scale research methods, researchers can inspect the role of regions that regulate activity of many thousands of genes.

The HapMap Project established cell cultures from participants from four populations as well as, for some samples, information from families, which can help to understand inheritance of genetic v
'/>"/>

Contact: Don Powell
don@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. The critical importance of mangroves to ocean life
2. New method confirms importance of fungi in Arctic nitrogen cycle
3. New insight into regulation of blood stem cells
4. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
5. MicroRNAs play a big part in gene regulation - and evolution
6. UCR chemist part of team identifying new areas of gene regulation
7. Bioinformatics reveals new gene regulation system
8. Researchers appeal for new regulations to save coral reefs from live fish trade
9. Novel enzyme offers new look at gene regulation
10. Researchers discover new form of cancer gene regulation
11. K-State researchers study gene regulation in insects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... nature,s ability to split the water molecule during ... artificial photosynthesis for clean, green and renewable energy ... scientists led by researchers with the Lawrence Berkeley ... Accelerator Laboratory. , Working at SLAC,s Linac ... x-ray laser, the researchers were able to take ...
(Date:7/9/2014)... studying critically ill children with traumatic injuries have ... are likely to develop a hospital-acquired infection. The ... and published online in June in the journal ... efforts that could lead to the clinical implementation ... prevent or reverse immune system damage following critical ...
(Date:7/9/2014)... University of Guelph scientist that involved fitting bumblebees ... to a neonicotinoid pesticide hampers bees, ability to ... Raine, a professor in Guelph,s School of Environmental ... was published July 9 in the British Ecological ... study shows how long-term pesticide exposure affects individual ...
Breaking Biology News(10 mins):Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3Bee foraging chronically impaired by pesticide exposure: Study 2
... as it has become known, began on March 11, ... recorded. Following the quake, a 40 to 50-foot tsunami ... estimated 20,000 missing or dead. The massive wave also ... plant. , The release of radioactivity from Fukushimaboth as ...
... may be the 21st century, but nearly half the ... or primitive stoves that burn wood, animal dung, charcoal ... ACS journal Environmental Science & Technology describes ... the obstacles that remain. Susan C. Anenberg ...
... its detection when mixed into meatballs and other food and ... is food for a thoughtful installment of the popular Newscripts ... News . C&EN is the weekly newsmagazine of the American ... Tullo, C&EN senior editor, uses the story to look behind ...
Cached Biology News:Meeting: 'Experts Convene to Examine Impacts of Fukushima on the Ocean' 2
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how latent viruses ... is the Epstein Barr Virus (EBV), and one of these ... chronic inflammatory disease that destroys the body’s joints. As predicted ... high concentrations of EBV DNA in their bodies (1). ...
(Date:1/15/2014)... Jan. 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") ... with R-Pharm, a leading Russian pharmaceutical company, to develop ... Russian Federation , Turkey ... (CIS). Nemonoxacin is a novel antibiotic for the treatment of ...
(Date:1/14/2014)... Calif. , Jan. 14, 2014 As pet owners drew ... doubt many of them wrote: "Take better care of my furry ... even designer clothes and top-brand carrying cases to take the little ... parents might also feel compelled to buy some pricey toys at ...
(Date:1/14/2014)... January 14, 2014 In recent years, ... and methods in product development and promotion has led ... This mistrust, fueled by concerns about the insidious impact ... reports of spectacular fines to the world’s biggest pharmas ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... Inc. ("Oncolytics") (TSX:ONC, NASDAQ: ONCY ) today ... clinical trial to evaluate the objective tumour response ... in patients with advanced cancers. , A total ... (melanoma (5), colorectal (4), gastric (1), pancreas (1), ...
... of probe that allows them to visualize single ribonucleic ... existing methods. The tool will help scientists learn more ... scientists currently use to image these transporters of genetic ... for synthetic RNA or a large number of fluorescent ...
... Nasdaq: PXSL ) today announced the appointment of ... its Board of Directors. , Mr ... Advisors LLC, a,U.S. based fund manager with an investment emphasis ... held a position on the Pharmaxis,share register since 2005. , ...
Cached Biology Technology:Oncolytics Biotech(R) Inc. Announces Positive Results of U.K. Phase II REOLYSIN(R) and Radiation Combination Clinical Trial 2Oncolytics Biotech(R) Inc. Announces Positive Results of U.K. Phase II REOLYSIN(R) and Radiation Combination Clinical Trial 3Researchers develop new way to see single RNA molecules inside living cells 2Researchers develop new way to see single RNA molecules inside living cells 3New Pharmaxis Board Appointment 2
Collected from 8-12 week-old New Zealand or Californian rabbits.,Supplied in lyophilized form....
Antibody specific for phosphorylattion of histone H3 that occurs during mitosis. Rabbit polyclonal serum. Antigen: Synthetic peptides derived from histone H3, phosphorylated at serines 10 or 28...
5 minutes from gel band to purified DNA...
...
Biology Products: