Navigation Links
The importance of (experimental) design
Date:2/25/2014

evolution? tienne Danchin of the University of Toulouse and Richard Wagner of the Vetmeduni's Konrad Lorenz Institute of Ethology wondered whether the results might not be influenced too much by the experimental design. Together with ric Wajnberg, a modelling specialist at the INRA in Sophia Antipolis, they simulated the data in the original paper and found that the results could be generated by chance.

The problem stems largely from the fallacy known as "regression to the mean" (RTM), which was first identified by Sir Francis Galton, a cousin of Charles Darwin, in the 19th century. It results from the fact that uncommonly large or small measurements are generally followed by more normal measurements simply because normal values are by definition far more common than extreme ones. In the Browns' experiment, when individuals are fostered from small to large colonies they will on average recruit to colonies that are statistically smaller than their foster colony because these are closer to the mean colony size and vice versa.

Danchin and Wagner actually found a second problem with the original data analysis. The so-called "spatial fallacy" was discovered by Arie van Noorwijk in 1984 and occurs when the set of potential dispersal sites differs among individuals according to where they were born. Together the two fallacies can account for the experiment's results, even in the absence of an inherited component of the selection of colony size.

A question of design

The latest calculations are important for two reasons. First, they call the original conclusions into question and should thus encourage researchers to reconsider the role of genetic factors in certain behavioural decisions. Secondly, they sound a clear warning to all those working in behavioural science. As Wagner says, "The biggest shock is that the very experimental design that is widely used to control for all extraneous effects actually creates the RTM f
'/>"/>

Contact: Richard Wagner
richard.wagner@vetmeduni.ac.at
43-148-909-15831
University of Veterinary Medicine -- Vienna
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
2. Study sheds new light on importance of human breast milk ingredient
3. Differences between human twins at birth highlight importance of intrauterine environment
4. Programming cells: The importance of the envelope
5. Video study shows which fish clean up coral reefs, showing importance of biodiversity
6. Gene discovery reveals importance of eating your greens
7. National survey highlights perceived importance of dietary protein to prevent weight gain
8. Emerging importance of computerized cognitive testing -- new therapies for dementia
9. Researchers have identified a novel immunological mechanism of great importance for vaccine developm
10. Keck award enables Carnegie Mellon and Stanford to dramatically expand crowdsourced RNA design
11. Report presents designs for study of cancer risks near US nuclear facilities
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The importance of (experimental) design
(Date:9/2/2014)... of Human Genetics (ASHG) and the National Human ... Institutes of Health, have named Katherine D. Blizinsky, ... the newest ASHG/NHGRI Genetics and Public Policy Fellow. ... and Public Policy Fellowship is intended to help ... and research policy at a national level. Fellows ...
(Date:9/2/2014)... digital distribution of media will have lower carbon ... when file sizes are large. , That,s the ... Journal of Industrial Ecology that looked at ... as PlayStation3. Researchers found that Blu-ray Discs delivered ... than game files downloaded over broadband Internet. For ...
(Date:9/2/2014)... baseball pitchers with poor core stability are more likely to ... of injury than are pitchers who have good control of ... study, 347 pitchers were assessed for lumbopelvic control during spring ... raised a leg to step up were up to three ... cumulative, not consecutive during the season than were pitchers ...
Breaking Biology News(10 mins):ASHG and NHGRI award genetics and public policy fellowship 2In pro baseball pitchers, weak core linked to more missed days 2In pro baseball pitchers, weak core linked to more missed days 3
... combat or cure human disease often involves a phase of ... a living mouse,s innards has real value. But with ... laboratory mice, the view becomes so murky several millimeters under ... future from the rodent,s entrails than they do extracting usable ...
... being: "So far scientific studies were limited mostly to ... of locomotion", says Fischer, Professor of Systematic Zoology and ... team started a comprehensive study about the locomotion of ... results. With enormous technical effort the scientists measured, ...
... Researchers of the Max Delbrck Center for Molecular ... cells to differentiate into diverse cell types and thus ... molecule E-cadherin hitherto primarily known for its ... "intracellular glue". If E-cadherin is absent, the stem cells ...
Cached Biology News:Better viewing through fluorescent nanotubes when peering into innards of a mouse 2Better viewing through fluorescent nanotubes when peering into innards of a mouse 3Dogs in motion 2Dogs in motion 3MDC researchers discover key molecule for stem cell pluripotency 2
(Date:9/2/2014)...  Xencor, Inc. (NASDAQ: XNCR ), ... for the treatment of autoimmune diseases, asthma and ... of Debra Zack , M.D., Ph.D., vice ... Lloyd Rowland , senior vice president, chief compliance ... expertise in biologics clinical development and medical affairs ...
(Date:9/2/2014)...  Spherix Incorporated (SPEX) -- an intellectual property development company committed ... announced that the United States Patent & Trademark Office ... month of August that are part of a standard ... patents are: , U.S.RE45,065 issued August ... and , U.S.RE45,095 issued August 26, 2014.  ...
(Date:9/1/2014)... (PRWEB) September 01, 2014 The ... and Diagnostics report provides comprehensive understanding and unprecedented ... entered into by the worlds leading life science ... and analysis of how and why companies enter ... a prospective partner’s negotiated deals terms provides critical ...
(Date:8/30/2014)... TX (PRWEB) August 31, 2014 ... is a professional and in-depth study on the ... in Global and China. , The report provides ... applications and industry chain structure. Global market analysis ... a focus on history, developments, trends and competitive ...
Breaking Biology Technology:Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 3United States Patent & Trademark Office Issues Three New Standard Essential Patents to Spherix 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3
... ... Discuss Opportunities and Challenges of Maize Cultivation Under Dry Conditions , ... Bordeaux, France (Vocus) February 4, 2010 ... to develop drought-tolerant crops, which will play a major role in sustainably increasing agricultural ...
... , RESEARCH TRIANGLE PARK, N.C. , ... a biotechnology company developing orally available antiviral therapeutics, announced today ... the company as Chief Medical Officer.   , Dr. Painter ... industry, including work in clinical development, clinical safety and pharmacovigilance, ...
... ... , ... has a unique opportunity today to engage, innovate and deliver sustainable solutions to the growing ... World CEO Forum of the Delhi Sustainable Development Summit 2010 in India. , ...
Cached Biology Technology:DuPont Leader: Drought-Tolerant Crops Developed Through Modern Breeding are Key to Sustainably Increasing Grain Production 2Chimerix Names Wendy Painter, M.D., M.P.H., as Chief Medical Officer 2Chimerix Names Wendy Painter, M.D., M.P.H., as Chief Medical Officer 3Sustainability Is A Business Imperative 2
... The Beacon 2000 Fluorescence Polarization System ... research and assay development. Standard Beacon ... 2000 System uses a quartz-halogen lamp ... of 360-700 nm. It accommodates all ...
Preparation Note: Prepared essentially by method of Singer, T.P., J. Biol. Chem., 174, 11 (1948). Quality Clarifier: Contains lipase Unit Definition: One unit will hydrolyze 1.0 μmole of p-ni...
... buffer, pH 10.2 give activity approx. 2X ... in diethanolamine buffer, pH 9.8 give activity ... system. Protein determined by Biuret Physical form: ... Unit Definition: One unit will hydrolyze 1 ...
... traps a wide variety of solvent vapors that can ... flask (GCF400) allows for the collection of liquid into ... time minimizes waiting period., Ultra low -104 ... , Digital Display of ...
Biology Products: